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Article: p53 Mutations in non-small cell lung carcinomas in Hong Kong

Titlep53 Mutations in non-small cell lung carcinomas in Hong Kong
Authors
KeywordsHong Kong
lung carcinoma
p53
Issue Date1996
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 1996, v. 109 n. 3, p. 718-726 How to Cite?
AbstractLung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcinoma were examined for the presence of mutations in the p53 gene by polymerase chain reaction single-stranded conformation polymorphism methods and for aberrant protein expression by immunostaining techniques. Eight-point mutations in the evolutionarily conserved exon 5 through 8 regions were detected. Abnormal expression of p53 detectable by immunostaining techniques was seen in 23 specimens tested. There was no statistically significant correlation between the detection of p53 aberrations and age, sex, smoking history, histologic type, and tumor stage. Aberrant p53 protein levels detectable by immunostaining were significantly associated with the clinical and nodal staging of the tumors.
Persistent Identifierhttp://hdl.handle.net/10722/49041
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorSkaanild, MTen_HK
dc.contributor.authorFok, CLen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorYew, WWen_HK
dc.date.accessioned2008-06-12T06:33:08Z-
dc.date.available2008-06-12T06:33:08Z-
dc.date.issued1996en_HK
dc.identifier.citationChest, 1996, v. 109 n. 3, p. 718-726en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49041-
dc.description.abstractLung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcinoma were examined for the presence of mutations in the p53 gene by polymerase chain reaction single-stranded conformation polymorphism methods and for aberrant protein expression by immunostaining techniques. Eight-point mutations in the evolutionarily conserved exon 5 through 8 regions were detected. Abnormal expression of p53 detectable by immunostaining techniques was seen in 23 specimens tested. There was no statistically significant correlation between the detection of p53 aberrations and age, sex, smoking history, histologic type, and tumor stage. Aberrant p53 protein levels detectable by immunostaining were significantly associated with the clinical and nodal staging of the tumors.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectHong Kongen_HK
dc.subjectlung carcinomaen_HK
dc.subjectp53en_HK
dc.titlep53 Mutations in non-small cell lung carcinomas in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=109&issue=3&spage=718&epage=726&date=1996&atitle=p53+mutations+in+non-small+cell+lung+carcinomas+in+Hong+Kongen_HK
dc.identifier.emailLung, ML:mlilung@hku.hken_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1378/chest.109.3.718en_HK
dc.identifier.pmid8617082en_HK
dc.identifier.scopuseid_2-s2.0-0011891330en_HK
dc.identifier.hkuros10761-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0011891330&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume109en_HK
dc.identifier.issue3en_HK
dc.identifier.spage718en_HK
dc.identifier.epage726en_HK
dc.identifier.isiWOS:A1996UA04300027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridSkaanild, MT=36927837300en_HK
dc.identifier.scopusauthoridFok, CL=6507491075en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridYew, WW=7005934631en_HK

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