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Article: Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B

TitlePhylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B
Authors
Issue Date2006
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2006, v. 80 n. 17, p. 8503-8509 How to Cite?
AbstractInfectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease. In this study, we investigated the phylogenetic origins of its genome segments and estimated the time of emergence of their most recent common ancestors. Moreover, with recently developed coalescence techniques, we reconstructed the past population dynamics of vvIBDV and timed the onset of its expansion to the late 1980s. Our analysis suggests that genome segment A of vvIBDV emerged at least 20 years before its expansion, which argues against the hypothesis that mutation of genome segment A is the major contributing factor in the emergence and expansion of vvIBDV. Alternatively, the phylogeny of genome segment B suggests a possible reassortment event estimated to have taken place around the mid-1980s, which seems to coincide with its expansion within approximately 5 years. We therefore hypothesize that the reassortment of genome segment B initiated vvIBDV expansion in the late 1980s, possibly by enhancing the virulence of the virus synergistically with its existing genome segment A. This report reveals the possible mechanisms leading to the emergence and expansion of vvIBDV, which would certainly provide insights into the scope of surveillance and prevention efforts regarding the disease. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/49034
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHon, CCen_HK
dc.contributor.authorLam, TYen_HK
dc.contributor.authorDrummond, Aen_HK
dc.contributor.authorRambaut, Aen_HK
dc.contributor.authorLee, YFen_HK
dc.contributor.authorYip, CWen_HK
dc.contributor.authorZeng, Fen_HK
dc.contributor.authorLam, PYen_HK
dc.contributor.authorNg, PTWen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2008-06-12T06:32:54Z-
dc.date.available2008-06-12T06:32:54Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Virology, 2006, v. 80 n. 17, p. 8503-8509en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49034-
dc.description.abstractInfectious bursal disease virus (IBDV) is a birnavirus causing immunosuppressive disease in chickens. Emergence of the very virulent form of IBDV (vvIBDV) in the late 1980s dramatically changed the epidemiology of the disease. In this study, we investigated the phylogenetic origins of its genome segments and estimated the time of emergence of their most recent common ancestors. Moreover, with recently developed coalescence techniques, we reconstructed the past population dynamics of vvIBDV and timed the onset of its expansion to the late 1980s. Our analysis suggests that genome segment A of vvIBDV emerged at least 20 years before its expansion, which argues against the hypothesis that mutation of genome segment A is the major contributing factor in the emergence and expansion of vvIBDV. Alternatively, the phylogeny of genome segment B suggests a possible reassortment event estimated to have taken place around the mid-1980s, which seems to coincide with its expansion within approximately 5 years. We therefore hypothesize that the reassortment of genome segment B initiated vvIBDV expansion in the late 1980s, possibly by enhancing the virulence of the virus synergistically with its existing genome segment A. This report reveals the possible mechanisms leading to the emergence and expansion of vvIBDV, which would certainly provide insights into the scope of surveillance and prevention efforts regarding the disease. Copyright © 2006, American Society for Microbiology. All Rights Reserved.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2006, v. 80 n. 17, p. 8503-8509en_HK
dc.subject.meshBirnaviridae Infections - epidemiology - veterinary - virologyen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshInfectious bursal disease virus - classification - genetics - pathogenicityen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshReassortant Viruses - classification - genetics - pathogenicityen_HK
dc.titlePhylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment Ben_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=80&issue=17&spage=8503&epage=8509&date=2006&atitle=Phylogenetic+analysis+reveals+a+correlation+between+the+expansion+of+very+virulent+infectious+bursal+disease+virus+and+reassortment+of+its+genome+segment+Ben_HK
dc.identifier.emailNg, PTW: ngtw@hku.hken_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityNg, PTW=rp00768en_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.00585-06en_HK
dc.identifier.pmid16912300-
dc.identifier.pmcidPMC1563883en_HK
dc.identifier.scopuseid_2-s2.0-33748672063en_HK
dc.identifier.hkuros125245-
dc.identifier.hkuros123016-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748672063&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue17en_HK
dc.identifier.spage8503en_HK
dc.identifier.epage8509en_HK
dc.identifier.isiWOS:000239934500020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridLam, TY=14527268100en_HK
dc.identifier.scopusauthoridDrummond, A=26643297100en_HK
dc.identifier.scopusauthoridRambaut, A=7004230842en_HK
dc.identifier.scopusauthoridLee, YF=14527155400en_HK
dc.identifier.scopusauthoridYip, CW=7101665559en_HK
dc.identifier.scopusauthoridZeng, F=7202911544en_HK
dc.identifier.scopusauthoridLam, PY=36847488300en_HK
dc.identifier.scopusauthoridNg, PTW=7402229732en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK

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