File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: How optimized is the translational machinery in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae?

TitleHow optimized is the translational machinery in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae?
Authors
Issue Date1998
PublisherGenetics Society of America. The Journal's web site is located at http://www.genetics.org/contents-by-date.0.shtml
Citation
Genetics, 1998, v. 149 n. 1, p. 37-44 How to Cite?
AbstractThe optimization of the translational machinery in cells requires the mutual adaptation of codon usage and tRNA concentration, and the adaptation of tRNA concentration to amino acid usage. Two predictions were derived based on a simple deterministic model of translation which assumes that elongation of the peptide chain is rate-limiting. The highest translational efficiency is achieved when the codon recognized by the most abundant tRNA reaches the maximum frequency. For each codon family, the tRNA concentration is optimally adapted to codon usage when the concentration of different tRNA species matches the square-root of the frequency of their corresponding synonymous codons. When tRNA concentration and codon usage are well adapted to each other, the optimal content of all tRNA species carrying the same amino acid should match the square-root of the frequency of the amino acid. These predictions are examined against empirical data from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae.
Persistent Identifierhttp://hdl.handle.net/10722/49029
ISSN
2015 Impact Factor: 4.644
2015 SCImago Journal Rankings: 4.270
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXia, Xen_HK
dc.date.accessioned2008-06-12T06:32:40Z-
dc.date.available2008-06-12T06:32:40Z-
dc.date.issued1998en_HK
dc.identifier.citationGenetics, 1998, v. 149 n. 1, p. 37-44en_HK
dc.identifier.issn0016-6731en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49029-
dc.description.abstractThe optimization of the translational machinery in cells requires the mutual adaptation of codon usage and tRNA concentration, and the adaptation of tRNA concentration to amino acid usage. Two predictions were derived based on a simple deterministic model of translation which assumes that elongation of the peptide chain is rate-limiting. The highest translational efficiency is achieved when the codon recognized by the most abundant tRNA reaches the maximum frequency. For each codon family, the tRNA concentration is optimally adapted to codon usage when the concentration of different tRNA species matches the square-root of the frequency of their corresponding synonymous codons. When tRNA concentration and codon usage are well adapted to each other, the optimal content of all tRNA species carrying the same amino acid should match the square-root of the frequency of the amino acid. These predictions are examined against empirical data from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherGenetics Society of America. The Journal's web site is located at http://www.genetics.org/contents-by-date.0.shtmlen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshEscherichia coli - geneticsen_HK
dc.subject.meshModels, Geneticen_HK
dc.subject.meshProtein Biosynthesisen_HK
dc.subject.meshRNA, Transfer - metabolismen_HK
dc.subject.meshSaccharomyces cerevisiae - geneticsen_HK
dc.titleHow optimized is the translational machinery in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-6731&volume=149&issue=1&spage=37&epage=44&date=1998&atitle=How+optimized+is+the+translational+machinery+in+Escherichia+coli,+Salmonella+typhimurium+and+Saccharomyces+cerevisiae?en_HK
dc.identifier.emailXia, X: xxia@hkusua.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9584084en_HK
dc.identifier.pmcidPMC1460137-
dc.identifier.hkuros32224-
dc.identifier.isiWOS:000073672500004-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats