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Article: Maximizing transcription efficiency causes codon usage bias

TitleMaximizing transcription efficiency causes codon usage bias
Authors
Issue Date1996
PublisherGenetics Society of America. The Journal's web site is located at http://www.genetics.org/contents-by-date.0.shtml
Citation
Genetics, 1996, v. 144 n. 3, p. 1309-1320 How to Cite?
AbstractThe rate of protein synthesis depends on both the rate of initiation of translation and the rate of elongation of the peptide chain. The rate of initiation depends on the encountering rate between ribosomes and mRNA; this rate in turn depends on the concentration of ribosomes and mRNA. Thus, patterns of codon usage that increase transcriptional efficiency should increase mRNA concentration, which in turn would increase the initiation rate and the rate of protein synthesis. An optimality model of the transcriptional process is presented with the prediction that the most frequently used ribonucleotide at the third codon sites in mRNA molecules should be the same as the most abundant ribonucleotide at the third codon sites in mRNA molecules should be the same as the most abundant ribonucleotide in the cellular matrix where mRNA is transcribed. This prediction is supported by four kinds of evidence. First, A-ending codons are the most frequently used synonymous codons in mitochondria, where ATP is much more abundant than that of the three other ribonucleotides. Second, A-ending codons are more frequently used in mitochondrial genes than in nuclear genes. Third, protein genes from organisms with a high metabolic rate use more A-ending codons and have higher A content in their introns than those from organisms with a low metabolic rate.
Persistent Identifierhttp://hdl.handle.net/10722/49028
ISSN
2015 Impact Factor: 4.644
2015 SCImago Journal Rankings: 4.270
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXia, Xen_HK
dc.date.accessioned2008-06-12T06:32:38Z-
dc.date.available2008-06-12T06:32:38Z-
dc.date.issued1996en_HK
dc.identifier.citationGenetics, 1996, v. 144 n. 3, p. 1309-1320en_HK
dc.identifier.issn0016-6731en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49028-
dc.description.abstractThe rate of protein synthesis depends on both the rate of initiation of translation and the rate of elongation of the peptide chain. The rate of initiation depends on the encountering rate between ribosomes and mRNA; this rate in turn depends on the concentration of ribosomes and mRNA. Thus, patterns of codon usage that increase transcriptional efficiency should increase mRNA concentration, which in turn would increase the initiation rate and the rate of protein synthesis. An optimality model of the transcriptional process is presented with the prediction that the most frequently used ribonucleotide at the third codon sites in mRNA molecules should be the same as the most abundant ribonucleotide at the third codon sites in mRNA molecules should be the same as the most abundant ribonucleotide in the cellular matrix where mRNA is transcribed. This prediction is supported by four kinds of evidence. First, A-ending codons are the most frequently used synonymous codons in mitochondria, where ATP is much more abundant than that of the three other ribonucleotides. Second, A-ending codons are more frequently used in mitochondrial genes than in nuclear genes. Third, protein genes from organisms with a high metabolic rate use more A-ending codons and have higher A content in their introns than those from organisms with a low metabolic rate.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherGenetics Society of America. The Journal's web site is located at http://www.genetics.org/contents-by-date.0.shtmlen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCodonen_HK
dc.subject.meshMathematical Computingen_HK
dc.subject.meshModels, Geneticen_HK
dc.subject.meshTranscription, Geneticen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.titleMaximizing transcription efficiency causes codon usage biasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-6731&volume=144&issue=3&spage=1309&epage=1320&date=1996&atitle=Maximizing+transcription+efficiency+causes+codon+usage+biasen_HK
dc.identifier.emailXia, X: xxia@hkusua.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8913770-
dc.identifier.pmcidPMC1207621-
dc.identifier.scopuseid_2-s2.0-0029970817-
dc.identifier.hkuros21213-
dc.identifier.isiWOS:A1996VP82600039-

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