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Article: Inhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasis

TitleInhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasis
Authors
Issue Date1998
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Journal Of Respiratory And Critical Care Medicine, 1998, v. 158 n. 3, p. 723-727 How to Cite?
AbstractAlthough corticosteroid therapy might be clinically beneficial for bronchiectasis, very little is known of its effects on the inflammatory and infective markers in bronchiectasis. We have therefore performed a double- blind, placebo-controlled study to evaluate the effects of a 4-wk administration of inhaled fluticasone in bronchiectasis. Twenty-four patients (12 female; mean age 51 yr) were randomized into receiving either inhaled fluticasone (500 μg twice daily) via the Accuhaler device (n = 12) or placebo. At each visit, spirometry, 24-h sputum volume, sputum leukocyte density, bacterial densities, and concentrations of interleukin (IL)-1β, IL- 8, tumor necrosis factor-alpha (TNF-α), and leukotriene B4 (LTB4) were determined. There was a significant (p < 0.05) decrease in sputum leukocyte density and IL-1β, IL-8, and LTB4 after fluticasone treatment. The fluticasone group had one and the placebo group three episodes of exacerbation. There were no significant changes in spirometry (p > 0.05) or any reported adverse reactions in either group. The results of this study show that high-dose fluticasone is effective in reducing the sputum inflammatory indices in bronchiectasis. Large-scale and long-term studies are indicated to evaluate the effects of inhaled steroid therapy on the inflammatory components in bronchiectasis.
Persistent Identifierhttp://hdl.handle.net/10722/49021
ISSN
2015 Impact Factor: 13.118
2015 SCImago Journal Rankings: 5.832
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorChan, KNen_HK
dc.contributor.authorHo, CSen_HK
dc.contributor.authorOoi, CCGen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2008-06-12T06:32:26Z-
dc.date.available2008-06-12T06:32:26Z-
dc.date.issued1998en_HK
dc.identifier.citationAmerican Journal Of Respiratory And Critical Care Medicine, 1998, v. 158 n. 3, p. 723-727en_HK
dc.identifier.issn1073-449Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49021-
dc.description.abstractAlthough corticosteroid therapy might be clinically beneficial for bronchiectasis, very little is known of its effects on the inflammatory and infective markers in bronchiectasis. We have therefore performed a double- blind, placebo-controlled study to evaluate the effects of a 4-wk administration of inhaled fluticasone in bronchiectasis. Twenty-four patients (12 female; mean age 51 yr) were randomized into receiving either inhaled fluticasone (500 μg twice daily) via the Accuhaler device (n = 12) or placebo. At each visit, spirometry, 24-h sputum volume, sputum leukocyte density, bacterial densities, and concentrations of interleukin (IL)-1β, IL- 8, tumor necrosis factor-alpha (TNF-α), and leukotriene B4 (LTB4) were determined. There was a significant (p < 0.05) decrease in sputum leukocyte density and IL-1β, IL-8, and LTB4 after fluticasone treatment. The fluticasone group had one and the placebo group three episodes of exacerbation. There were no significant changes in spirometry (p > 0.05) or any reported adverse reactions in either group. The results of this study show that high-dose fluticasone is effective in reducing the sputum inflammatory indices in bronchiectasis. Large-scale and long-term studies are indicated to evaluate the effects of inhaled steroid therapy on the inflammatory components in bronchiectasis.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.orgen_HK
dc.relation.ispartofAmerican Journal of Respiratory and Critical Care Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAndrostadienes - administration & dosage - therapeutic useen_HK
dc.subject.meshAnti-Inflammatory Agents - administration & dosage - therapeutic useen_HK
dc.subject.meshBronchiectasis - drug therapy - immunology - microbiology - pathologyen_HK
dc.subject.meshSputum - cytology - drug effects - immunology - microbiologyen_HK
dc.subject.meshAdministration, Topicalen_HK
dc.titleInhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1073-449X&volume=158&issue=3&spage=723&epage=727&date=1998&atitle=Inhaled+fluticasone+reduces+sputum+inflammatory+indices+in+severe+bronchiectasisen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9730996-
dc.identifier.scopuseid_2-s2.0-0031721046en_HK
dc.identifier.hkuros36084-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031721046&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume158en_HK
dc.identifier.issue3en_HK
dc.identifier.spage723en_HK
dc.identifier.epage727en_HK
dc.identifier.isiWOS:000075861900006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridChan, KN=15737866400en_HK
dc.identifier.scopusauthoridHo, CS=36986008400en_HK
dc.identifier.scopusauthoridOoi, CCG=18837726600en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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