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Article: dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice

Titledsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice
Authors
KeywordsMelanosome transfer
Myosin 5A
Vesicle transport
Issue Date2004
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2004, v. 101 n. 48, p. 16831-16836 How to Cite?
AbstractMYO5A is a major actin-based vesicle transport motor that binds to one of its cargos, the melanosome, by means of a RAB27A/MLPH receptor. When one of the members of this receptor-motor complex is mutated, the melanosomes clump in the perinuclear region of the melanocyte and are transferred unevenly to the developing hair, leading to a dilution of coat color. Mutation of a fourth gene, dilute suppressor (dsu), suppresses this coat color dilution. MYO5A is required for the peripheral accumulation of melanosomes in melanocytes, but its role in melanosome transfer to neighboring keratinocytes and the hair is unknown. Here, we show that MYO5A is nonessential for melanosome transfer, although pigment incorporation into the hair in MYO5A-deficient mice is uneven, probably due to the clumping of melanosomes that occurs in the perinuclear region of mutant melanocytes. We also show that dsu is caused by a loss-of-function mutation in a unique vertebrate-specific protein that appears to function in an MYO5A-independent pathway to alter pigment incorporation into the hair. Therefore, dsu identifies a unique protein involved in pigmentation of the mammalian hair.
Persistent Identifierhttp://hdl.handle.net/10722/48988
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorO'Sullivan, TNen_HK
dc.contributor.authorWu, XSen_HK
dc.contributor.authorRachel, RAen_HK
dc.contributor.authorHuang, JDen_HK
dc.contributor.authorSwing, DAen_HK
dc.contributor.authorMatesic, LEen_HK
dc.contributor.authorHammer III, JAen_HK
dc.contributor.authorCopeland, NGen_HK
dc.contributor.authorJenkins, NAen_HK
dc.date.accessioned2008-06-12T06:31:28Z-
dc.date.available2008-06-12T06:31:28Z-
dc.date.issued2004en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2004, v. 101 n. 48, p. 16831-16836en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48988-
dc.description.abstractMYO5A is a major actin-based vesicle transport motor that binds to one of its cargos, the melanosome, by means of a RAB27A/MLPH receptor. When one of the members of this receptor-motor complex is mutated, the melanosomes clump in the perinuclear region of the melanocyte and are transferred unevenly to the developing hair, leading to a dilution of coat color. Mutation of a fourth gene, dilute suppressor (dsu), suppresses this coat color dilution. MYO5A is required for the peripheral accumulation of melanosomes in melanocytes, but its role in melanosome transfer to neighboring keratinocytes and the hair is unknown. Here, we show that MYO5A is nonessential for melanosome transfer, although pigment incorporation into the hair in MYO5A-deficient mice is uneven, probably due to the clumping of melanosomes that occurs in the perinuclear region of mutant melanocytes. We also show that dsu is caused by a loss-of-function mutation in a unique vertebrate-specific protein that appears to function in an MYO5A-independent pathway to alter pigment incorporation into the hair. Therefore, dsu identifies a unique protein involved in pigmentation of the mammalian hair.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsNational Academy of Sciences Proceedings. Copyright © National Academy of Sciences.en_HK
dc.subjectMelanosome transferen_HK
dc.subjectMyosin 5Aen_HK
dc.subjectVesicle transporten_HK
dc.titledsu functions in a MYO5A-independent pathway to suppress the coat color of dilute miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=101&issue=48&spage=16831&epage=16836&date=2004&atitle=dsu+functions+in+a+MYO5A-independent+pathway+to+suppress+the+coat+color+of+dilute+miceen_HK
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_HK
dc.identifier.authorityHuang, JD=rp00451en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1073/pnas.0407339101en_HK
dc.identifier.pmid15550542en_HK
dc.identifier.pmcidPMC534743en_HK
dc.identifier.scopuseid_2-s2.0-10044225973en_HK
dc.identifier.hkuros97133-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10044225973&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume101en_HK
dc.identifier.issue48en_HK
dc.identifier.spage16831en_HK
dc.identifier.epage16836en_HK
dc.identifier.isiWOS:000225508400024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridO'Sullivan, TN=7006551957en_HK
dc.identifier.scopusauthoridWu, XS=7407065744en_HK
dc.identifier.scopusauthoridRachel, RA=7003812116en_HK
dc.identifier.scopusauthoridHuang, JD=8108660600en_HK
dc.identifier.scopusauthoridSwing, DA=6701731157en_HK
dc.identifier.scopusauthoridMatesic, LE=6603230001en_HK
dc.identifier.scopusauthoridHammer III, JA=35453674500en_HK
dc.identifier.scopusauthoridCopeland, NG=35374759300en_HK
dc.identifier.scopusauthoridJenkins, NA=35379887700en_HK

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