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Article: EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

TitleEEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia
Authors
Issue Date1997
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 1997, v. 94 n. 6, p. 2563-2568 How to Cite?
AbstractThe MLL gene, the closest human homologue to the Drosophila trithorax gene, undergoes chromosomal translocation with a large number of different partner genes in both acute lymphoid and acute myeloid leukemias. We have identified a new partner gene, EEN, fused to MLL in a case of acute myeloid leukemia. The gene is located on chromosome 19p13, where two other MLL partner genes, ENL and ELL/MEN have also been identified. The deduced protein of 368 aa contains a central α-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the Grb2/Sem-5/Drk family of genes. Sequence analysis of the fusion MLL/EEN transcript in our patient reveals that exon 6 of MLL is fused to the N- terminal end of EEN, a fusion that would create a chimeric protein that includes the major functional domain of EEN. EEN is expressed in a variety of tissue types and encodes a protein of approximately 46 kDa. The EEN protein is the human homologue of a member of a recently described murine SH3 domain- containing protein family. It is also highly related to a putative gene identified in Caenorhabditis elegans, and a number of similar sequences are present in the EST databases of several species.
Persistent Identifierhttp://hdl.handle.net/10722/48975
ISSN
2014 Impact Factor: 9.674
2014 SCImago Journal Rankings: 5.781
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, CWen_HK
dc.contributor.authorCaldas, Cen_HK
dc.contributor.authorLiu, MMen_HK
dc.contributor.authorChen, SJen_HK
dc.contributor.authorHuang, QHen_HK
dc.contributor.authorGu, LJen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorWiedemann, LMen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2008-06-12T06:31:11Z-
dc.date.available2008-06-12T06:31:11Z-
dc.date.issued1997en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 1997, v. 94 n. 6, p. 2563-2568en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48975-
dc.description.abstractThe MLL gene, the closest human homologue to the Drosophila trithorax gene, undergoes chromosomal translocation with a large number of different partner genes in both acute lymphoid and acute myeloid leukemias. We have identified a new partner gene, EEN, fused to MLL in a case of acute myeloid leukemia. The gene is located on chromosome 19p13, where two other MLL partner genes, ENL and ELL/MEN have also been identified. The deduced protein of 368 aa contains a central α-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the Grb2/Sem-5/Drk family of genes. Sequence analysis of the fusion MLL/EEN transcript in our patient reveals that exon 6 of MLL is fused to the N- terminal end of EEN, a fusion that would create a chimeric protein that includes the major functional domain of EEN. EEN is expressed in a variety of tissue types and encodes a protein of approximately 46 kDa. The EEN protein is the human homologue of a member of a recently described murine SH3 domain- containing protein family. It is also highly related to a putative gene identified in Caenorhabditis elegans, and a number of similar sequences are present in the EST databases of several species.en_HK
dc.format.extent384 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.rightsNational Academy of Sciences Proceedings. Copyright © National Academy of Sciences.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshChromosomes, Human, Pair 19en_HK
dc.subject.meshDNA-Binding Proteins - geneticsen_HK
dc.subject.meshLeukemia, Myeloid, Acute - geneticsen_HK
dc.subject.meshMultigene Familyen_HK
dc.subject.meshProto-Oncogenesen_HK
dc.titleEEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=94&issue=6&spage=2563&epage=2568&date=1997&atitle=EEN+encodes+for+a+member+of+a+new+family+of+proteins+containing+an+Src+homology+3+domain+and+is+the+third+gene+located+on+chromosome+19p13+that+fuses+to+MLL+in+human+leukemiaen_HK
dc.identifier.emailSham, MH:mhsham@hkucc.hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1073/pnas.94.6.2563en_HK
dc.identifier.pmid9122235en_HK
dc.identifier.pmcidPMC20128en_HK
dc.identifier.scopuseid_2-s2.0-0000778884en_HK
dc.identifier.hkuros43402-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0000778884&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume94en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2563en_HK
dc.identifier.epage2568en_HK
dc.identifier.isiWOS:A1997WP33400086-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSo, CW=7102919928en_HK
dc.identifier.scopusauthoridCaldas, C=7006688992en_HK
dc.identifier.scopusauthoridLiu, MM=7406297704en_HK
dc.identifier.scopusauthoridChen, SJ=13310288700en_HK
dc.identifier.scopusauthoridHuang, QH=7403634376en_HK
dc.identifier.scopusauthoridGu, LJ=7202674702en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridWiedemann, LM=35467788500en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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