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Article: EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia
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TitleEEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia
 
AuthorsSo, CW1
Caldas, C5
Liu, MM3
Chen, SJ3
Huang, QH3
Gu, LJ2
Sham, MH1
Wiedemann, LM5
Chan, LC1 4
 
Issue Date1997
 
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
 
CitationProceedings Of The National Academy Of Sciences Of The United States Of America, 1997, v. 94 n. 6, p. 2563-2568 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.94.6.2563
 
AbstractThe MLL gene, the closest human homologue to the Drosophila trithorax gene, undergoes chromosomal translocation with a large number of different partner genes in both acute lymphoid and acute myeloid leukemias. We have identified a new partner gene, EEN, fused to MLL in a case of acute myeloid leukemia. The gene is located on chromosome 19p13, where two other MLL partner genes, ENL and ELL/MEN have also been identified. The deduced protein of 368 aa contains a central α-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the Grb2/Sem-5/Drk family of genes. Sequence analysis of the fusion MLL/EEN transcript in our patient reveals that exon 6 of MLL is fused to the N- terminal end of EEN, a fusion that would create a chimeric protein that includes the major functional domain of EEN. EEN is expressed in a variety of tissue types and encodes a protein of approximately 46 kDa. The EEN protein is the human homologue of a member of a recently described murine SH3 domain- containing protein family. It is also highly related to a putative gene identified in Caenorhabditis elegans, and a number of similar sequences are present in the EST databases of several species.
 
ISSN0027-8424
2013 Impact Factor: 9.809
 
DOIhttp://dx.doi.org/10.1073/pnas.94.6.2563
 
PubMed Central IDPMC20128
 
ISI Accession Number IDWOS:A1997WP33400086
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSo, CW
 
dc.contributor.authorCaldas, C
 
dc.contributor.authorLiu, MM
 
dc.contributor.authorChen, SJ
 
dc.contributor.authorHuang, QH
 
dc.contributor.authorGu, LJ
 
dc.contributor.authorSham, MH
 
dc.contributor.authorWiedemann, LM
 
dc.contributor.authorChan, LC
 
dc.date.accessioned2008-06-12T06:31:11Z
 
dc.date.available2008-06-12T06:31:11Z
 
dc.date.issued1997
 
dc.description.abstractThe MLL gene, the closest human homologue to the Drosophila trithorax gene, undergoes chromosomal translocation with a large number of different partner genes in both acute lymphoid and acute myeloid leukemias. We have identified a new partner gene, EEN, fused to MLL in a case of acute myeloid leukemia. The gene is located on chromosome 19p13, where two other MLL partner genes, ENL and ELL/MEN have also been identified. The deduced protein of 368 aa contains a central α-helical region and a C-terminal Src homology 3 (SH3) domain most similar to the C-terminal SH3 domain found in the Grb2/Sem-5/Drk family of genes. Sequence analysis of the fusion MLL/EEN transcript in our patient reveals that exon 6 of MLL is fused to the N- terminal end of EEN, a fusion that would create a chimeric protein that includes the major functional domain of EEN. EEN is expressed in a variety of tissue types and encodes a protein of approximately 46 kDa. The EEN protein is the human homologue of a member of a recently described murine SH3 domain- containing protein family. It is also highly related to a putative gene identified in Caenorhabditis elegans, and a number of similar sequences are present in the EST databases of several species.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent384 bytes
 
dc.format.mimetypetext/html
 
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 1997, v. 94 n. 6, p. 2563-2568 [How to Cite?]
DOI: http://dx.doi.org/10.1073/pnas.94.6.2563
 
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.94.6.2563
 
dc.identifier.epage2568
 
dc.identifier.hkuros43402
 
dc.identifier.isiWOS:A1997WP33400086
 
dc.identifier.issn0027-8424
2013 Impact Factor: 9.809
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC20128
 
dc.identifier.pmid9122235
 
dc.identifier.scopuseid_2-s2.0-0000778884
 
dc.identifier.spage2563
 
dc.identifier.urihttp://hdl.handle.net/10722/48975
 
dc.identifier.volume94
 
dc.languageeng
 
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
 
dc.relation.referencesReferences in Scopus
 
dc.rightsNational Academy of Sciences Proceedings. Copyright © National Academy of Sciences.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshChromosomes, Human, Pair 19
 
dc.subject.meshDNA-Binding Proteins - genetics
 
dc.subject.meshLeukemia, Myeloid, Acute - genetics
 
dc.subject.meshMultigene Family
 
dc.subject.meshProto-Oncogenes
 
dc.titleEEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Shanghai Second Medical University
  3. Shanghai Institute of Technology
  4. Queen Mary Hospital Hong Kong
  5. Leukaemia Research Fund Centre