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Article: Evidence for a multifocal origin of papillary serous carcinoma of the peritoneum

TitleEvidence for a multifocal origin of papillary serous carcinoma of the peritoneum
Authors
Issue Date1995
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1995, v. 55 n. 3, p. 490-492 How to Cite?
AbstractHistopathological evidence suggests that papillary serous carcinoma of the peritoneum (PSCP) may be multifocal in origin. Utilizing a PCR based method to detect tandem repeat polymorphisms in formalin fixed tissue, loss of heterozygosity at eight loci on chromosomes 1, 3, 4, and 17 was studied in six cases of PSCP. Loss of heterozygosity was assessed at between 5 and 11 tumor sites/patient. Allelic losses at 4 loci (1q32-qter, 3p14.3-21.1, 17q12, 17q21.3-23) were noted. Three cases demonstrated a different pattern of allelic loss at various anatomic sites within the same patient. In an additional case, a mutation of the p53 gene, detected by quantitative PCR followed by single-strand conformation polymorphism analysis, was detected in only 2 of 5 tumor sites. The pattern of allelic loss and the mutational pattern of the p53 gene varied at tumor sites within the same patient in 4 of 6 cases of PSCP. These findings are consistent with histopathological evidence that PSCP is multifocal in origin.
Persistent Identifierhttp://hdl.handle.net/10722/48957
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMuto, MGen_HK
dc.contributor.authorWelch, WRen_HK
dc.contributor.authorMok, SCHen_HK
dc.contributor.authorBandera, CAen_HK
dc.contributor.authorFishbaugh, PMen_HK
dc.contributor.authorTsao , SWen_HK
dc.contributor.authorLau, CCen_HK
dc.contributor.authorGoodman, HMen_HK
dc.contributor.authorKnapp, RCen_HK
dc.contributor.authorBerkowitz, RSen_HK
dc.date.accessioned2008-06-12T06:30:41Z-
dc.date.available2008-06-12T06:30:41Z-
dc.date.issued1995en_HK
dc.identifier.citationCancer Research, 1995, v. 55 n. 3, p. 490-492en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48957-
dc.description.abstractHistopathological evidence suggests that papillary serous carcinoma of the peritoneum (PSCP) may be multifocal in origin. Utilizing a PCR based method to detect tandem repeat polymorphisms in formalin fixed tissue, loss of heterozygosity at eight loci on chromosomes 1, 3, 4, and 17 was studied in six cases of PSCP. Loss of heterozygosity was assessed at between 5 and 11 tumor sites/patient. Allelic losses at 4 loci (1q32-qter, 3p14.3-21.1, 17q12, 17q21.3-23) were noted. Three cases demonstrated a different pattern of allelic loss at various anatomic sites within the same patient. In an additional case, a mutation of the p53 gene, detected by quantitative PCR followed by single-strand conformation polymorphism analysis, was detected in only 2 of 5 tumor sites. The pattern of allelic loss and the mutational pattern of the p53 gene varied at tumor sites within the same patient in 4 of 6 cases of PSCP. These findings are consistent with histopathological evidence that PSCP is multifocal in origin.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshChromosome deletionen_HK
dc.subject.meshChromosomes, humanen_HK
dc.subject.meshCystadenocarcinoma, papillary - genetics - pathologyen_HK
dc.subject.meshPeritoneal neoplasms - genetics - pathologyen_HK
dc.subject.meshUterine neoplasms - genetics - pathologyen_HK
dc.titleEvidence for a multifocal origin of papillary serous carcinoma of the peritoneumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=55&issue=3&spage=490&epage=492&date=1995&atitle=Evidence+for+a+multifocal+origin+of+papillary+serous+carcinoma+of+the+peritoneumen_HK
dc.identifier.emailTsao , SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao , SW=rp00399en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid7834614-
dc.identifier.scopuseid_2-s2.0-0028954509en_HK
dc.identifier.hkuros4718-
dc.identifier.volume55en_HK
dc.identifier.issue3en_HK
dc.identifier.spage490en_HK
dc.identifier.epage492en_HK
dc.identifier.isiWOS:A1995QD71700009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMuto, MG=7102795179en_HK
dc.identifier.scopusauthoridWelch, WR=35265514400en_HK
dc.identifier.scopusauthoridMok, SCH=7006015487en_HK
dc.identifier.scopusauthoridBandera, CA=6603770076en_HK
dc.identifier.scopusauthoridFishbaugh, PM=6507784159en_HK
dc.identifier.scopusauthoridTsao , SW=7102813116en_HK
dc.identifier.scopusauthoridLau, CC=7401968381en_HK
dc.identifier.scopusauthoridGoodman, HM=55207871500en_HK
dc.identifier.scopusauthoridKnapp, RC=7201853287en_HK
dc.identifier.scopusauthoridBerkowitz, RS=7201352221en_HK

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