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Article: Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells

TitleEvidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells
Authors
Issue Date1998
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1998, v. 58 n. 22, p. 5019-5022 How to Cite?
AbstractCellular senescence is a programmed cell response leading to growth arrest in human diploid fibroblasts. We have shown that a nasopharyngeal carcinoma cell line, CNE1, following treatment by the DNA-damaging agent cisplatin, can undergo cellular senescent-like growth arrest, similar to fibroblasts, judged by cellular morphological changes and the expression of senescence-associated β-galactosidase (SA-β-gal). This senescent-like change was dose related; at 0.5 μg/ml, the percentage of cisplatin-induced SA-β-gal-positive cells was high (40-96%), and the staining was intense. Higher doses (1.0 and 2.0 μg/ml) of cisplatin induced lower SA-β-gal expression (30-70%), and the process was irreversible. This cisplatin- induced cellular senescent-like response was not due to the inhibition of telomerase activity. Our results indicate that cellular senescent-like pathways exist in nasopharyngeal carcinoma cells and can be induced by cisplatin. Our evidence suggests that cellular senescent-like responses may be a cellular protection mechanism that acts differently in response to different degrees of cellular damage.
Persistent Identifierhttp://hdl.handle.net/10722/48954
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Xen_HK
dc.contributor.authorWong, SCHen_HK
dc.contributor.authorPan, Jen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorFung, KHYen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorNicholls, JMen_HK
dc.date.accessioned2008-06-12T06:30:37Z-
dc.date.available2008-06-12T06:30:37Z-
dc.date.issued1998en_HK
dc.identifier.citationCancer Research, 1998, v. 58 n. 22, p. 5019-5022en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48954-
dc.description.abstractCellular senescence is a programmed cell response leading to growth arrest in human diploid fibroblasts. We have shown that a nasopharyngeal carcinoma cell line, CNE1, following treatment by the DNA-damaging agent cisplatin, can undergo cellular senescent-like growth arrest, similar to fibroblasts, judged by cellular morphological changes and the expression of senescence-associated β-galactosidase (SA-β-gal). This senescent-like change was dose related; at 0.5 μg/ml, the percentage of cisplatin-induced SA-β-gal-positive cells was high (40-96%), and the staining was intense. Higher doses (1.0 and 2.0 μg/ml) of cisplatin induced lower SA-β-gal expression (30-70%), and the process was irreversible. This cisplatin- induced cellular senescent-like response was not due to the inhibition of telomerase activity. Our results indicate that cellular senescent-like pathways exist in nasopharyngeal carcinoma cells and can be induced by cisplatin. Our evidence suggests that cellular senescent-like responses may be a cellular protection mechanism that acts differently in response to different degrees of cellular damage.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntineoplastic Agents - pharmacologyen_HK
dc.subject.meshCell Aging - drug effectsen_HK
dc.subject.meshCisplatin - pharmacologyen_HK
dc.subject.meshbeta-Galactosidase - metabolismen_HK
dc.subject.meshBiological Markersen_HK
dc.titleEvidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=58&issue=22&spage=5019&epage=5022&date=1999&atitle=Evidence+of+cisplatin-induced+senescent-like+growth+arrest+in+nasopharyngeal+carcinoma+cellsen_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9823301-
dc.identifier.scopuseid_2-s2.0-0032533504en_HK
dc.identifier.hkuros39153-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032533504&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume58en_HK
dc.identifier.issue22en_HK
dc.identifier.spage5019en_HK
dc.identifier.epage5022en_HK
dc.identifier.isiWOS:000077000400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, X=7501854829en_HK
dc.identifier.scopusauthoridWong, SCH=36631370700en_HK
dc.identifier.scopusauthoridPan, J=7404098399en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridFung, KHY=16180183300en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridSham, JST=7101655565en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK

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