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Article: Ovarian morphology and endocrine characteristics of female sheep fetuses that are heterozygous or homozygous for the inverdale prolificacy gene (fecX')

TitleOvarian morphology and endocrine characteristics of female sheep fetuses that are heterozygous or homozygous for the inverdale prolificacy gene (fecX')
Authors
Issue Date1997
PublisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/
Citation
Biology Of Reproduction, 1997, v. 57 n. 5, p. 1183-1192 How to Cite?
AbstractThe Inverdale gene (fecX'), located on the X chromosome, is a major gene affecting the ovulation rate of sheep. At each ovulation, ewes heterozygous (I+) for the fecX' gene ovulate, on average, one more egg than noncarriers (++), whereas ewes that are homozygous (II) for this gene are infertile and have 'streak' ovaries. Since formation of the ovary occurs in fetal life, it is possible that the fecX' gene influences ovarian development before birth. The aims of this study were to examine the effects of the fecX' gene on germ cell development, follicular formation and growth, and plasma gonadotropin concentrations at 5 different days of gestation (i.e., Days 40, 90, 105, 120, and 135) and also in adult life. The results suggest that one copy of the X- linked mutation in female fetuses leads to a retardation of germ cell development at Days 40 and 90 of gestation. However, from Day 105 of gestation, follicular formation and growth appear normal. By contrast, in females with two copies of the X-linked mutation, germ cell development and follicular formation appear normal, but thereafter follicular growth from the primary stage of development is impaired. During fetal life the plasma concentrations of FSH and LH, although not measurable at Day 40, were similar between all the genotypes at Day 105, 120, and 135 of gestation. The only exception was for LH at Day 90 in the I+ and II animals: in ewes with these genotypes the plasma concentrations of LH were similar but significantly lower (p < 0.01) than in the ++ genotype. In adult animals the plasma concentrations of FSH and LH were not different between the ++ and I+ genotypes, reflecting similar levels of ovarian follicular activity. However, in adult II animals, the plasma concentrations of FSH and LH were significantly higher (both p < 0.01) than in the ++ and I+ genotypes, reflecting the absence of normal secondary and antral follicles. In summary, these data show that the fecX' gene affects ovarian development before birth and that the nature of the effect is influenced by whether the female fetus is a homozygous or heterozygous carrier of the X-linked mutation.
Persistent Identifierhttp://hdl.handle.net/10722/48951
ISSN
2015 Impact Factor: 3.471
2015 SCImago Journal Rankings: 1.646
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSmith, Pen_HK
dc.contributor.authorO, WSen_HK
dc.contributor.authorCorrigan, KAen_HK
dc.contributor.authorSmith, Ten_HK
dc.contributor.authorLundy, Ten_HK
dc.contributor.authorDavis, GHen_HK
dc.contributor.authorMcNatty, KPen_HK
dc.date.accessioned2008-06-12T06:30:33Z-
dc.date.available2008-06-12T06:30:33Z-
dc.date.issued1997en_HK
dc.identifier.citationBiology Of Reproduction, 1997, v. 57 n. 5, p. 1183-1192en_HK
dc.identifier.issn0006-3363en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48951-
dc.description.abstractThe Inverdale gene (fecX'), located on the X chromosome, is a major gene affecting the ovulation rate of sheep. At each ovulation, ewes heterozygous (I+) for the fecX' gene ovulate, on average, one more egg than noncarriers (++), whereas ewes that are homozygous (II) for this gene are infertile and have 'streak' ovaries. Since formation of the ovary occurs in fetal life, it is possible that the fecX' gene influences ovarian development before birth. The aims of this study were to examine the effects of the fecX' gene on germ cell development, follicular formation and growth, and plasma gonadotropin concentrations at 5 different days of gestation (i.e., Days 40, 90, 105, 120, and 135) and also in adult life. The results suggest that one copy of the X- linked mutation in female fetuses leads to a retardation of germ cell development at Days 40 and 90 of gestation. However, from Day 105 of gestation, follicular formation and growth appear normal. By contrast, in females with two copies of the X-linked mutation, germ cell development and follicular formation appear normal, but thereafter follicular growth from the primary stage of development is impaired. During fetal life the plasma concentrations of FSH and LH, although not measurable at Day 40, were similar between all the genotypes at Day 105, 120, and 135 of gestation. The only exception was for LH at Day 90 in the I+ and II animals: in ewes with these genotypes the plasma concentrations of LH were similar but significantly lower (p < 0.01) than in the ++ genotype. In adult animals the plasma concentrations of FSH and LH were not different between the ++ and I+ genotypes, reflecting similar levels of ovarian follicular activity. However, in adult II animals, the plasma concentrations of FSH and LH were significantly higher (both p < 0.01) than in the ++ and I+ genotypes, reflecting the absence of normal secondary and antral follicles. In summary, these data show that the fecX' gene affects ovarian development before birth and that the nature of the effect is influenced by whether the female fetus is a homozygous or heterozygous carrier of the X-linked mutation.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/en_HK
dc.relation.ispartofBiology of Reproductionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshFetus - physiologyen_HK
dc.subject.meshGenes, Regulator - geneticsen_HK
dc.subject.meshHormones - blooden_HK
dc.subject.meshOvary - anatomy & histology - embryologyen_HK
dc.subject.meshFollicle Stimulating Hormone - blooden_HK
dc.titleOvarian morphology and endocrine characteristics of female sheep fetuses that are heterozygous or homozygous for the inverdale prolificacy gene (fecX')en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3363&volume=57&issue=5&spage=1183&epage=1192&date=1997&atitle=Ovarian+morphology+and+endocrine+characteristics+of+female+sheep+fetuses+that+are+heterozygous+or+homozygous+for+the+Inverdale+prolificacy+gene+(fecX1)en_HK
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1095/biolreprod57.5.1183en_HK
dc.identifier.pmid9369186en_HK
dc.identifier.scopuseid_2-s2.0-0030733222en_HK
dc.identifier.hkuros28826-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030733222&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1183en_HK
dc.identifier.epage1192en_HK
dc.identifier.isiWOS:A1997YD11400030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSmith, P=8432710700en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK
dc.identifier.scopusauthoridCorrigan, KA=8433951800en_HK
dc.identifier.scopusauthoridSmith, T=35467832300en_HK
dc.identifier.scopusauthoridLundy, T=6601962187en_HK
dc.identifier.scopusauthoridDavis, GH=7404343597en_HK
dc.identifier.scopusauthoridMcNatty, KP=7007075253en_HK

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