File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Intra-articular injection of ketorolac in the rat knee joint: Effect on articular cartilage and synovium

TitleIntra-articular injection of ketorolac in the rat knee joint: Effect on articular cartilage and synovium
Authors
KeywordsAnalgesia intra-articular
Analgesics non-opioid ketorolac
Rat
Issue Date1998
PublisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/
Citation
British Journal Of Anaesthesia, 1998, v. 80 n. 6, p. 837-839 How to Cite?
AbstractWe have investigated the effects of intraarticular (i.a.) administration of ketorolac in the rat knee joint. Thirty Sprague-Dawley rats were given 0.25 ml of a standard preparation of ketorolac trometamol (10 mg ml-1) by injection into the right knee joint and 0.25 ml of 0.9% physiological saline solution by injection into the left knee as a control. Ten rats were killed at 24 h, 10 at 48 h and 10 at 5 days after injection. The joints were prepared and sectioned for histological examination. There was significantly more inflammation in those knees that had received i.a. ketorolac at all times of examination, with the most severe changes occurring 5 days after injection. A further group of 10 rats were given 0.25 ml of 10% w/v ethanol in physiological saline (similar to the vehicle for parenteral ketorolac) injected into the knee joint, with a 0.9% saline control injected in the other knee. These rats were then killed at 5 days (as this was the time interval after which we found the maximum inflammatory response in the earlier phase of our study). The joints were prepared and examined histologically. We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.
Persistent Identifierhttp://hdl.handle.net/10722/48939
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorThompson, Nen_HK
dc.date.accessioned2008-06-12T06:30:12Z-
dc.date.available2008-06-12T06:30:12Z-
dc.date.issued1998en_HK
dc.identifier.citationBritish Journal Of Anaesthesia, 1998, v. 80 n. 6, p. 837-839en_HK
dc.identifier.issn0007-0912en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48939-
dc.description.abstractWe have investigated the effects of intraarticular (i.a.) administration of ketorolac in the rat knee joint. Thirty Sprague-Dawley rats were given 0.25 ml of a standard preparation of ketorolac trometamol (10 mg ml-1) by injection into the right knee joint and 0.25 ml of 0.9% physiological saline solution by injection into the left knee as a control. Ten rats were killed at 24 h, 10 at 48 h and 10 at 5 days after injection. The joints were prepared and sectioned for histological examination. There was significantly more inflammation in those knees that had received i.a. ketorolac at all times of examination, with the most severe changes occurring 5 days after injection. A further group of 10 rats were given 0.25 ml of 10% w/v ethanol in physiological saline (similar to the vehicle for parenteral ketorolac) injected into the knee joint, with a 0.9% saline control injected in the other knee. These rats were then killed at 5 days (as this was the time interval after which we found the maximum inflammatory response in the earlier phase of our study). The joints were prepared and examined histologically. We feel that the absence of inflammatory changes in these joints make it unlikely that ethanol was responsible for the inflammation produced by ketorolac injection.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/en_HK
dc.relation.ispartofBritish Journal of Anaesthesiaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAnalgesia intra-articularen_HK
dc.subjectAnalgesics non-opioid ketorolacen_HK
dc.subjectRaten_HK
dc.titleIntra-articular injection of ketorolac in the rat knee joint: Effect on articular cartilage and synoviumen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0912&volume=80&issue=6&spage=837&epage=839&date=1998&atitle=Intra-articular+injection+of+ketorolac+in+the+rat+knee+joint:+effect+on+articular+cartilage+and+synoviumen_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1093/bja/80.6.837en_HK
dc.identifier.pmid9771318-
dc.identifier.scopuseid_2-s2.0-0031745194en_HK
dc.identifier.hkuros32583-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031745194&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue6en_HK
dc.identifier.spage837en_HK
dc.identifier.epage839en_HK
dc.identifier.isiWOS:000074189000027-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridThompson, N=16937521600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats