Article: Candida species exhibit differential in vitro hemolytic activities

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TitleCandida species exhibit differential in vitro hemolytic activities
AuthorsLuo, G
Samaranayake, LP
Yau, JYY
Issue Date2000
PublisherAmerican Society for Microbiology.
CitationJournal of Clinical Microbiology, 2000, v. 39 n. 8, p. 2971-2974 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.39.8.2971-2974.2001
AbstractA total of 80 Candida isolates representing 14 species were examined for their respective responses to an in vitro hemolytic test. A modification of a previously described plate assay system where the yeasts are incubated on glucose (3%)-enriched sheep blood agar in a carbon dioxide (5%)-rich environment for 48 h was used to evaluate the hemolytic activity. A group of eight Candida species which included Candida albicans (15 isolates), C. dubliniensis (2), C. kefyr (2), C. krusei (4), C. zeylanoides (1), C. glabrata (34), C. tropicalis (5), and C. lusitaniae (2) demonstrated both alpha and beta hemolysis at 48 h postinoculation. Only alpha hemolysis was detectable in four Candida species, viz., C. famata (3), C. guilliermondii (4), C. rugosa (1), and C. utilis (1), while C. parapsilosis (5) and C. pelliculosa (1) failed to demonstrate any hemolytic activity after incubation for 48 h or longer. This is the first study to demonstrate the variable expression profiles of hemolysins by different Candida species.
ISSN0095-1137
2010 Impact Factor: 4.22
DOIhttp://dx.doi.org/10.1128/JCM.39.8.2971-2974.2001
HKUROS62515
PubMed ID11474025
PubMed Central IDPMC88272
Find published version via
Persistent Identifierhttp://hdl.handle.net/10722/48931
DC Field
Value
dc.contributor.authorLuo, G
dc.contributor.authorSamaranayake, LP
dc.contributor.authorYau, JYY
dc.date.accessioned2008-06-12T06:29:58Z
dc.date.available2008-06-12T06:29:58Z
dc.date.issued2000
dc.description.abstractA total of 80 Candida isolates representing 14 species were examined for their respective responses to an in vitro hemolytic test. A modification of a previously described plate assay system where the yeasts are incubated on glucose (3%)-enriched sheep blood agar in a carbon dioxide (5%)-rich environment for 48 h was used to evaluate the hemolytic activity. A group of eight Candida species which included Candida albicans (15 isolates), C. dubliniensis (2), C. kefyr (2), C. krusei (4), C. zeylanoides (1), C. glabrata (34), C. tropicalis (5), and C. lusitaniae (2) demonstrated both alpha and beta hemolysis at 48 h postinoculation. Only alpha hemolysis was detectable in four Candida species, viz., C. famata (3), C. guilliermondii (4), C. rugosa (1), and C. utilis (1), while C. parapsilosis (5) and C. pelliculosa (1) failed to demonstrate any hemolytic activity after incubation for 48 h or longer. This is the first study to demonstrate the variable expression profiles of hemolysins by different Candida species.
dc.description.naturePublished_or_final_version
dc.format.extent384 bytes
dc.format.mimetypetext/html
dc.identifier.citationJournal of Clinical Microbiology, 2000, v. 39 n. 8, p. 2971-2974 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.39.8.2971-2974.2001
dc.identifier.doihttp://dx.doi.org/10.1128/JCM.39.8.2971-2974.2001
dc.identifier.hkuros62515
dc.identifier.issn0095-1137
2010 Impact Factor: 4.22
dc.identifier.openurl
dc.identifier.pmcidPMC88272
dc.identifier.pmid11474025
dc.identifier.urihttp://hdl.handle.net/10722/48931
dc.languageeng
dc.publisherAmerican Society for Microbiology.
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.
dc.rightsCopyright © American Society for Microbiology, Journal of Clinical Microbiology, 2000, v. 39 n. 8, p. 2971-2974
dc.subject.meshCandida - growth & development - metabolism
dc.subject.meshCandidiasis - microbiology
dc.subject.meshHemolysis
dc.subject.meshHemolysin Proteins - biosynthesis
dc.subject.meshMycology - methods
dc.titleCandida species exhibit differential in vitro hemolytic activities
dc.typeArticle