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Article: Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury

TitleProtection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury
Authors
KeywordsDanshen
LPS
Salvia miltiorrhiza
TNF
Issue Date2006
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimp
Citation
International Immunopharmacology, 2006, v. 6 n. 5, p. 750-758 How to Cite?
AbstractLipopolysaccharide (LPS) has been implicated as one of the major cause of Gram-negative bacteria-induced sepsis that are life-threatening syndromes occurring in intensive care unit patients. Many natural products derived from medicinal plants may contain therapeutic values on protecting endotoxemia-induced sepsis by virtue their ability to modulate multiple pro-inflammatory cytokines. In the present study, we show that Salvia miltiorrhiza (SM) BUNGE or Danshen, used in treatment of various systemic and surgical infections in the hospitals of China, was able to block the lethal toxicity of LPS in mice via suppression of TNF-α release and protection on liver injury. The ability of SM to suppress LPS-induced TNF-α release is further confirmed by in vitro experiments conducted on human peripheral blood leukocytes (PBL) and the RAW 264.7 macrophage cell line. Immunophenotyping by flow cytometry shows improved T-helper cell (CD4) and T-suppressor cells (CD8) ratio in SM-treated PBL and splenocytes of LPS-challenged mice. The drop in plasma glutamate-pyruvate transaminase (GPT) induced by LPS provides evidence that SM can protect hepatic damage. The present study explains some known biological activities of SM, and supports the clinical application of SM in the prevention of inflammatory diseases induced by Gram-negative bacteria. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/48685
ISSN
2015 Impact Factor: 2.551
2015 SCImago Journal Rankings: 0.941
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, JMFen_HK
dc.contributor.authorSit, WHen_HK
dc.contributor.authorLee, CLen_HK
dc.contributor.authorFu, KHMen_HK
dc.contributor.authorChan, DKOen_HK
dc.date.accessioned2008-05-22T04:21:20Z-
dc.date.available2008-05-22T04:21:20Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Immunopharmacology, 2006, v. 6 n. 5, p. 750-758en_HK
dc.identifier.issn1567-5769en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48685-
dc.description.abstractLipopolysaccharide (LPS) has been implicated as one of the major cause of Gram-negative bacteria-induced sepsis that are life-threatening syndromes occurring in intensive care unit patients. Many natural products derived from medicinal plants may contain therapeutic values on protecting endotoxemia-induced sepsis by virtue their ability to modulate multiple pro-inflammatory cytokines. In the present study, we show that Salvia miltiorrhiza (SM) BUNGE or Danshen, used in treatment of various systemic and surgical infections in the hospitals of China, was able to block the lethal toxicity of LPS in mice via suppression of TNF-α release and protection on liver injury. The ability of SM to suppress LPS-induced TNF-α release is further confirmed by in vitro experiments conducted on human peripheral blood leukocytes (PBL) and the RAW 264.7 macrophage cell line. Immunophenotyping by flow cytometry shows improved T-helper cell (CD4) and T-suppressor cells (CD8) ratio in SM-treated PBL and splenocytes of LPS-challenged mice. The drop in plasma glutamate-pyruvate transaminase (GPT) induced by LPS provides evidence that SM can protect hepatic damage. The present study explains some known biological activities of SM, and supports the clinical application of SM in the prevention of inflammatory diseases induced by Gram-negative bacteria. © 2005 Elsevier B.V. All rights reserved.en_HK
dc.format.extent264776 bytes-
dc.format.extent581 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimpen_HK
dc.relation.ispartofInternational Immunopharmacologyen_HK
dc.rightsInternational Immunopharmacology. Copyright © Elsevier Ltd.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectDanshenen_HK
dc.subjectLPSen_HK
dc.subjectSalvia miltiorrhizaen_HK
dc.subjectTNFen_HK
dc.titleProtection of lethal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injuryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1567-5769&volume=6&issue=5&spage=750&epage=758&date=2006&atitle=Protection+of+lethal+toxicity+of+endotoxin+by+Salvia+miltiorrhiza+BUNGE+is+via+reduction+in+tumor+necrosis+factor+alpha+release+and+liver+injuryen_HK
dc.identifier.emailWan, JMF: jmfwan@hku.hken_HK
dc.identifier.emailChan, DKO: chand@hku.hken_HK
dc.identifier.authorityWan, JMF=rp00798en_HK
dc.identifier.authorityChan, DKO=rp00540en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1016/j.intimp.2005.11.008en_HK
dc.identifier.pmid16546705-
dc.identifier.scopuseid_2-s2.0-33645035494en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645035494&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue5en_HK
dc.identifier.spage750en_HK
dc.identifier.epage758en_HK
dc.identifier.isiWOS:000236555700005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWan, JMF=8930305000en_HK
dc.identifier.scopusauthoridSit, WH=8528923000en_HK
dc.identifier.scopusauthoridLee, CL=9277221100en_HK
dc.identifier.scopusauthoridFu, KHM=36902086200en_HK
dc.identifier.scopusauthoridChan, DKO=7402216545en_HK

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