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Article: Regulation of junction dynamics in the testis--transcriptional and post-translational regulations of cell junction proteins

TitleRegulation of junction dynamics in the testis--transcriptional and post-translational regulations of cell junction proteins
Authors
KeywordsSertoli cells
Cell junctions
Transcription
Post-translation
Ubiquitination
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce
Citation
Molecular and Cellular Endocrinology, 2006, v. 250 n. 1-2, p. 25-35 How to Cite?
AbstractCell junctions are the sites at which cells attach to the neighboring cells. They do not only maintain tissue integrity, their turnover also plays a crucial role in cell development and morphogenesis. In the testis, tight junctions and adherens junctions are dynamically remodeled to allow the movement of post-meiotic germ cells across the seminiferous epithelium and the timely release of spermatids into the tubular lumen. There is growing evidence that this dynamic remodeling of cell junctions is mediated by several mechanisms at the transcriptional and post-translational levels. This review summarizes what is known about the transcriptional regulation, ubiquitination and endocytosis that are involved in modulating junction dynamics in epithelial cells. It also highlights the recent findings on the regulation of junction dynamics in the testis and the specific areas that require further research for a thorough understanding of the role of junction remodeling in spermatogenesis. Understanding the junction dynamics in the seminiferous epithelium may unfold new targets for non-hormonal male contraceptive development.
Persistent Identifierhttp://hdl.handle.net/10722/48682
ISSN
2015 Impact Factor: 3.859
2015 SCImago Journal Rankings: 2.116
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLui, WYen_HK
dc.contributor.authorLee, WWMen_HK
dc.date.accessioned2008-05-22T04:21:15Z-
dc.date.available2008-05-22T04:21:15Z-
dc.date.issued2006en_HK
dc.identifier.citationMolecular and Cellular Endocrinology, 2006, v. 250 n. 1-2, p. 25-35en_HK
dc.identifier.issn0303-7207en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48682-
dc.description.abstractCell junctions are the sites at which cells attach to the neighboring cells. They do not only maintain tissue integrity, their turnover also plays a crucial role in cell development and morphogenesis. In the testis, tight junctions and adherens junctions are dynamically remodeled to allow the movement of post-meiotic germ cells across the seminiferous epithelium and the timely release of spermatids into the tubular lumen. There is growing evidence that this dynamic remodeling of cell junctions is mediated by several mechanisms at the transcriptional and post-translational levels. This review summarizes what is known about the transcriptional regulation, ubiquitination and endocytosis that are involved in modulating junction dynamics in epithelial cells. It also highlights the recent findings on the regulation of junction dynamics in the testis and the specific areas that require further research for a thorough understanding of the role of junction remodeling in spermatogenesis. Understanding the junction dynamics in the seminiferous epithelium may unfold new targets for non-hormonal male contraceptive development.en_HK
dc.format.extent309279 bytes-
dc.format.extent902 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mceen_HK
dc.rightsMolecular and Cellular Endocrinology. Copyright © Elsevier Ireland Ltd.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectSertoli cellsen_HK
dc.subjectCell junctionsen_HK
dc.subjectTranscriptionen_HK
dc.subjectPost-translationen_HK
dc.subjectUbiquitinationen_HK
dc.titleRegulation of junction dynamics in the testis--transcriptional and post-translational regulations of cell junction proteinsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-7207&volume=250&issue=1-2&spage=25&epage=35&date=2006&atitle=Regulation+of+junction+dynamics+in+the+testis--transcriptional+and+post-translational+regulations+of+cell+junction+proteinsen_HK
dc.identifier.emailLui, WY: wylui@HKUCC.hku.hken_HK
dc.identifier.emailLee, WWM: hrszlwm@hku.hken_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1016/j.mce.2005.12.021en_HK
dc.identifier.pmid16431017-
dc.identifier.scopuseid_2-s2.0-33646177339-
dc.identifier.hkuros113973-
dc.identifier.isiWOS:000238020900005-

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