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Article: Tolerance associated with cord blood transplantation may depend on the state of host dentritic cells

TitleTolerance associated with cord blood transplantation may depend on the state of host dentritic cells
Authors
KeywordsCord blood
Cytokine
Dendritic cell
T regulatory cell
Tolerance
Issue Date2004
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2004, v. 126 n. 4, p. 517-526 How to Cite?
AbstractAllogeneic cord blood (CB) transplantation is associated with less severe graft-versus-host disease (GvHD), thought to be due to the immaturity of CB T cells, but how T cells interact with host and donor-derived dendritic cells (DCs) to initiate GvHD has not been elucidated. We therefore investigated the responses of CB and adult blood CD4 + T cells co-cultured with adult host DCs of different maturities. Primed by adult host DCs, CB and adult blood CD4 + T cells underwent similar changes in the expression of CD45RA/45RO, CD25, CD40L and CTLA-4. However, CB CD4 + T cells, when primed by either immature or Bacillus Calmette-Guerin mycobacteria-treated adult host DCs, produced lower interferon-γ (IFN-γ) and higher interleukin-10 (IL-10), which is a regulatory T cell-like cytokine profile, as compared with adult blood CD4 + T cells. In contrast, lipopolysaccharide (LPS)-treated adult host DCs significantly up-regulated IFN-γ and down-regulated IL-10 production levels from CB CD4 + T cells to that from adult blood CD4 + T cells. The sustained low IFN-γ and high IL-10 production from CB CD4 + T cells co-cultured with adult blood DCs might account for the less severe GvHD occurrence after CB transplantation, which could be reversed by LPS-treated adult blood DCs.
Persistent Identifierhttp://hdl.handle.net/10722/48652
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Een_HK
dc.contributor.authorLaw, HKWen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2008-05-22T04:20:14Z-
dc.date.available2008-05-22T04:20:14Z-
dc.date.issued2004en_HK
dc.identifier.citationBritish Journal Of Haematology, 2004, v. 126 n. 4, p. 517-526en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48652-
dc.description.abstractAllogeneic cord blood (CB) transplantation is associated with less severe graft-versus-host disease (GvHD), thought to be due to the immaturity of CB T cells, but how T cells interact with host and donor-derived dendritic cells (DCs) to initiate GvHD has not been elucidated. We therefore investigated the responses of CB and adult blood CD4 + T cells co-cultured with adult host DCs of different maturities. Primed by adult host DCs, CB and adult blood CD4 + T cells underwent similar changes in the expression of CD45RA/45RO, CD25, CD40L and CTLA-4. However, CB CD4 + T cells, when primed by either immature or Bacillus Calmette-Guerin mycobacteria-treated adult host DCs, produced lower interferon-γ (IFN-γ) and higher interleukin-10 (IL-10), which is a regulatory T cell-like cytokine profile, as compared with adult blood CD4 + T cells. In contrast, lipopolysaccharide (LPS)-treated adult host DCs significantly up-regulated IFN-γ and down-regulated IL-10 production levels from CB CD4 + T cells to that from adult blood CD4 + T cells. The sustained low IFN-γ and high IL-10 production from CB CD4 + T cells co-cultured with adult blood DCs might account for the less severe GvHD occurrence after CB transplantation, which could be reversed by LPS-treated adult blood DCs.en_HK
dc.format.extent151783 bytes-
dc.format.extent4956 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_HK
dc.subjectCord blooden_HK
dc.subjectCytokineen_HK
dc.subjectDendritic cellen_HK
dc.subjectT regulatory cellen_HK
dc.subjectToleranceen_HK
dc.titleTolerance associated with cord blood transplantation may depend on the state of host dentritic cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=126&issue=4&spage=517&epage=526&date=2004&atitle=Tolerance+associated+with+cord+blood+transplantation+may+depend+on+the+state+of+host+dendritic+cellsen_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1111/j.1365-2141.2004.05061.xen_HK
dc.identifier.pmid15287945en_HK
dc.identifier.scopuseid_2-s2.0-4143088075en_HK
dc.identifier.hkuros96427-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4143088075&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume126en_HK
dc.identifier.issue4en_HK
dc.identifier.spage517en_HK
dc.identifier.epage526en_HK
dc.identifier.isiWOS:000223036300009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiu, E=7202240063en_HK
dc.identifier.scopusauthoridLaw, HKW=7101939394en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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