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Article: Lupus nephritis in Chinese children--a territory-wide cohort study in Hong Kong

TitleLupus nephritis in Chinese children--a territory-wide cohort study in Hong Kong
Authors
KeywordsChinese
Children
Mortality
Morbidity
Nephritis
Issue Date2006
PublisherSpringer-Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htm
Citation
Pediatric Nephrology, 2006, v. 21 n. 8, p. 1104-1112 How to Cite?
Abstract
We report a multicenter study of Chinese children in Hong Kong with systemic lupus erythematosus (SLE) nephritis. Children were included if: they fulfilled the ACR criteria, had significant proteinuria or casturia, were Chinese and younger than 19 years and had been diagnosed with SLE between January 1990 and December 2003. Investigators in each center retrieved data on clinical features, biopsy reports, treatment and outcome of these patients. There were 128 patients (eight boys, 120 girls; mean age: 11.9+/-2.8 years). About 50% presented with multisystem illness and 40% with nephritic/nephrotic symptoms. Negative anti-dsDNA antibodies were found in 6% of the patients. Renal biopsy revealed WHO Class II, III, IV and V nephritis in 13 (10%), 22 (17%), 69 (54%) and 13 (10%) patients, respectively. The clinical severity of the nephritis did not accurately predict renal biopsy findings. The follow-up period ranged from 1 to 16.5 years (mean+/-SD: 5.76+/-3.61 years). During the study five patients died (two from lupus flare, one from cardiomyopathy, two from infections). Four patients had endstage renal failure (ESRF) (one died during a lupus flare). All deaths and end-stage renal failure occurred in the Class IV nephritis group. Chronic organ damage was infrequent in the survivors. The actuarial patient survival rates at 5, 10 and 15 years of age were 95.3, 91.8, and 91.8%, respectively. For Class IV nephritis patients, the survival rates without ESRF at 5, 10, and 15 years were 91.5, 82.3 and 76%, respectively. The survival and chronic morbidity rates of the Chinese SLE children in the present study are comparable to those of other published studies.
Persistent Identifierhttp://hdl.handle.net/10722/48649
ISSN
2013 Impact Factor: 2.881
ISI Accession Number ID

 

Author Affiliations
  1. Kwong Wah Hospital
  2. Tseung Kwan O Hospital
  3. Princess Margaret Hospital Hong Kong
  4. Tuen Mun Hospital
  5. Alice HML Nethersole Hospital
  6. Queen Elizabeth Hospital Hong Kong
  7. Prince of Wales Hospital Hong Kong
  8. Pamela Youde Nethersole Eastern Hospital
  9. United Christian Hospital Hong Kong
  10. Queen Mary Hospital Hong Kong
  11. Caritas Medical Centre Hong Kong
DC FieldValueLanguage
dc.contributor.authorWong, SNen_HK
dc.contributor.authorTse, KCen_HK
dc.contributor.authorLee, TLen_HK
dc.contributor.authorLee, KWen_HK
dc.contributor.authorChim, Sen_HK
dc.contributor.authorLee, KPen_HK
dc.contributor.authorChu, WPen_HK
dc.contributor.authorChan, Wen_HK
dc.contributor.authorFong, KWen_HK
dc.contributor.authorHui, Jen_HK
dc.contributor.authorLi, SPSen_HK
dc.contributor.authorYeung, PSen_HK
dc.contributor.authorYuen, SFen_HK
dc.contributor.authorHo, ACHen_HK
dc.contributor.authorLeung, LCKen_HK
dc.contributor.authorLuk, Den_HK
dc.contributor.authorChan, SYen_HK
dc.contributor.authorCheung, HMen_HK
dc.contributor.authorChow, CMen_HK
dc.contributor.authorLau, Den_HK
dc.date.accessioned2008-05-22T04:20:08Z-
dc.date.available2008-05-22T04:20:08Z-
dc.date.issued2006en_HK
dc.identifier.citationPediatric Nephrology, 2006, v. 21 n. 8, p. 1104-1112en_HK
dc.identifier.issn0931-041Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/48649-
dc.description.abstractWe report a multicenter study of Chinese children in Hong Kong with systemic lupus erythematosus (SLE) nephritis. Children were included if: they fulfilled the ACR criteria, had significant proteinuria or casturia, were Chinese and younger than 19 years and had been diagnosed with SLE between January 1990 and December 2003. Investigators in each center retrieved data on clinical features, biopsy reports, treatment and outcome of these patients. There were 128 patients (eight boys, 120 girls; mean age: 11.9+/-2.8 years). About 50% presented with multisystem illness and 40% with nephritic/nephrotic symptoms. Negative anti-dsDNA antibodies were found in 6% of the patients. Renal biopsy revealed WHO Class II, III, IV and V nephritis in 13 (10%), 22 (17%), 69 (54%) and 13 (10%) patients, respectively. The clinical severity of the nephritis did not accurately predict renal biopsy findings. The follow-up period ranged from 1 to 16.5 years (mean+/-SD: 5.76+/-3.61 years). During the study five patients died (two from lupus flare, one from cardiomyopathy, two from infections). Four patients had endstage renal failure (ESRF) (one died during a lupus flare). All deaths and end-stage renal failure occurred in the Class IV nephritis group. Chronic organ damage was infrequent in the survivors. The actuarial patient survival rates at 5, 10 and 15 years of age were 95.3, 91.8, and 91.8%, respectively. For Class IV nephritis patients, the survival rates without ESRF at 5, 10, and 15 years were 91.5, 82.3 and 76%, respectively. The survival and chronic morbidity rates of the Chinese SLE children in the present study are comparable to those of other published studies.en_HK
dc.format.extent161946 bytes-
dc.format.extent29821 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherSpringer-Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htmen_HK
dc.rightsThe original publication is available at www.springerlink.comen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectChineseen_HK
dc.subjectChildrenen_HK
dc.subjectMortalityen_HK
dc.subjectMorbidityen_HK
dc.subjectNephritisen_HK
dc.titleLupus nephritis in Chinese children--a territory-wide cohort study in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0931-041X&volume=21&issue=8&spage=1104&epage=1112&date=2006&atitle=Lupus+nephritis+in+Chinese+children--a+territory-wide+cohort+study+in+Hong+Kongen_HK
dc.identifier.emailWong, SN: snwong@HKUCC.hku.hken_HK
dc.identifier.emailLee, TL: leetsz@HKUCC.hku.hken_HK
dc.identifier.emailChim, S: schim@HKUCC.hku.hken_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1007/s00467-006-0052-3en_HK
dc.identifier.pmid16639624en_HK
dc.identifier.scopuseid_2-s2.0-33746135656-
dc.identifier.isiWOS:000239818100007-

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