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Article: Lupus nephritis in Chinese children--a territory-wide cohort study in Hong Kong
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TitleLupus nephritis in Chinese children--a territory-wide cohort study in Hong Kong
 
AuthorsWong, SN4
Tse, KC3
Lee, TL10
Lee, KW6
Chim, S10
Lee, KP5
Chu, WP
Chan, W6
Fong, KW4
Hui, J7
Li, SPS4
Yeung, PS11
Yuen, SF8
Ho, ACH7
Leung, LCK1
Luk, D9
Chan, SY10
Cheung, HM7
Chow, CM7
Lau, D2
 
KeywordsChinese
Children
Mortality
Morbidity
Nephritis
 
Issue Date2006
 
PublisherSpringer-Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htm
 
CitationPediatric Nephrology, 2006, v. 21 n. 8, p. 1104-1112 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00467-006-0052-3
 
AbstractWe report a multicenter study of Chinese children in Hong Kong with systemic lupus erythematosus (SLE) nephritis. Children were included if: they fulfilled the ACR criteria, had significant proteinuria or casturia, were Chinese and younger than 19 years and had been diagnosed with SLE between January 1990 and December 2003. Investigators in each center retrieved data on clinical features, biopsy reports, treatment and outcome of these patients. There were 128 patients (eight boys, 120 girls; mean age: 11.9+/-2.8 years). About 50% presented with multisystem illness and 40% with nephritic/nephrotic symptoms. Negative anti-dsDNA antibodies were found in 6% of the patients. Renal biopsy revealed WHO Class II, III, IV and V nephritis in 13 (10%), 22 (17%), 69 (54%) and 13 (10%) patients, respectively. The clinical severity of the nephritis did not accurately predict renal biopsy findings. The follow-up period ranged from 1 to 16.5 years (mean+/-SD: 5.76+/-3.61 years). During the study five patients died (two from lupus flare, one from cardiomyopathy, two from infections). Four patients had endstage renal failure (ESRF) (one died during a lupus flare). All deaths and end-stage renal failure occurred in the Class IV nephritis group. Chronic organ damage was infrequent in the survivors. The actuarial patient survival rates at 5, 10 and 15 years of age were 95.3, 91.8, and 91.8%, respectively. For Class IV nephritis patients, the survival rates without ESRF at 5, 10, and 15 years were 91.5, 82.3 and 76%, respectively. The survival and chronic morbidity rates of the Chinese SLE children in the present study are comparable to those of other published studies.
 
ISSN0931-041X
2013 Impact Factor: 2.881
 
DOIhttp://dx.doi.org/10.1007/s00467-006-0052-3
 
ISI Accession Number IDWOS:000239818100007
 
DC FieldValue
dc.contributor.authorWong, SN
 
dc.contributor.authorTse, KC
 
dc.contributor.authorLee, TL
 
dc.contributor.authorLee, KW
 
dc.contributor.authorChim, S
 
dc.contributor.authorLee, KP
 
dc.contributor.authorChu, WP
 
dc.contributor.authorChan, W
 
dc.contributor.authorFong, KW
 
dc.contributor.authorHui, J
 
dc.contributor.authorLi, SPS
 
dc.contributor.authorYeung, PS
 
dc.contributor.authorYuen, SF
 
dc.contributor.authorHo, ACH
 
dc.contributor.authorLeung, LCK
 
dc.contributor.authorLuk, D
 
dc.contributor.authorChan, SY
 
dc.contributor.authorCheung, HM
 
dc.contributor.authorChow, CM
 
dc.contributor.authorLau, D
 
dc.date.accessioned2008-05-22T04:20:08Z
 
dc.date.available2008-05-22T04:20:08Z
 
dc.date.issued2006
 
dc.description.abstractWe report a multicenter study of Chinese children in Hong Kong with systemic lupus erythematosus (SLE) nephritis. Children were included if: they fulfilled the ACR criteria, had significant proteinuria or casturia, were Chinese and younger than 19 years and had been diagnosed with SLE between January 1990 and December 2003. Investigators in each center retrieved data on clinical features, biopsy reports, treatment and outcome of these patients. There were 128 patients (eight boys, 120 girls; mean age: 11.9+/-2.8 years). About 50% presented with multisystem illness and 40% with nephritic/nephrotic symptoms. Negative anti-dsDNA antibodies were found in 6% of the patients. Renal biopsy revealed WHO Class II, III, IV and V nephritis in 13 (10%), 22 (17%), 69 (54%) and 13 (10%) patients, respectively. The clinical severity of the nephritis did not accurately predict renal biopsy findings. The follow-up period ranged from 1 to 16.5 years (mean+/-SD: 5.76+/-3.61 years). During the study five patients died (two from lupus flare, one from cardiomyopathy, two from infections). Four patients had endstage renal failure (ESRF) (one died during a lupus flare). All deaths and end-stage renal failure occurred in the Class IV nephritis group. Chronic organ damage was infrequent in the survivors. The actuarial patient survival rates at 5, 10 and 15 years of age were 95.3, 91.8, and 91.8%, respectively. For Class IV nephritis patients, the survival rates without ESRF at 5, 10, and 15 years were 91.5, 82.3 and 76%, respectively. The survival and chronic morbidity rates of the Chinese SLE children in the present study are comparable to those of other published studies.
 
dc.description.naturepostprint
 
dc.format.extent161946 bytes
 
dc.format.extent29821 bytes
 
dc.format.mimetypeapplication/pdf
 
dc.format.mimetypeapplication/pdf
 
dc.identifier.citationPediatric Nephrology, 2006, v. 21 n. 8, p. 1104-1112 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00467-006-0052-3
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00467-006-0052-3
 
dc.identifier.isiWOS:000239818100007
 
dc.identifier.issn0931-041X
2013 Impact Factor: 2.881
 
dc.identifier.openurl
 
dc.identifier.pmid16639624
 
dc.identifier.scopuseid_2-s2.0-33746135656
 
dc.identifier.urihttp://hdl.handle.net/10722/48649
 
dc.languageeng
 
dc.publisherSpringer-Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htm
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectChinese
 
dc.subjectChildren
 
dc.subjectMortality
 
dc.subjectMorbidity
 
dc.subjectNephritis
 
dc.titleLupus nephritis in Chinese children--a territory-wide cohort study in Hong Kong
 
dc.typeArticle
 
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<contributor.author>Chim, S</contributor.author>
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Author Affiliations
  1. Kwong Wah Hospital
  2. Tseung Kwan O Hospital
  3. Princess Margaret Hospital Hong Kong
  4. Tuen Mun Hospital
  5. Alice HML Nethersole Hospital
  6. Queen Elizabeth Hospital Hong Kong
  7. Prince of Wales Hospital Hong Kong
  8. Pamela Youde Nethersole Eastern Hospital
  9. United Christian Hospital Hong Kong
  10. Queen Mary Hospital Hong Kong
  11. Caritas Medical Centre Hong Kong