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Article: Risk Factors for Development of Paradoxical Response During Antituberculosis Therapy in HIV-Negative Patients

TitleRisk Factors for Development of Paradoxical Response During Antituberculosis Therapy in HIV-Negative Patients
Authors
KeywordsImmunocompromised Host
Bone Marrow Transplantation - immunology
Immunosuppressive Agents - administration & dosage
Lymphocyte Count
Issue Date2003
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htm
Citation
European Journal Of Clinical Microbiology And Infectious Diseases, 2003, v. 22 n. 10, p. 597-602 How to Cite?
Abstract
The risk factors for development of paradoxical response were studied in a cohort of 104 patients with culture-documented Mycobacterium tuberculosis infection. Paradoxical deterioration occurred in 16 (15.4%) patients (case group) during antituberculosis therapy, involving lungs and pleura (n=4), spine and paraspinal tissue (n=5), intracranium (n=3), peritoneum (n=2), bone and joint (n=1), and lymph node (n=1). The median time from commencement of treatment to paradoxical deterioration was 56 days (range, 20-109 days). Compared with 53 patients without clinical deterioration after antituberculosis therapy (control group), patients with paradoxical response were more likely to have extrapulmonary involvement (62.5% vs. 17.0%; P<0.05) at initial diagnosis, to have lower baseline lymphocyte counts (672±315 cells/μl vs. 1,328±467 cells/μl; P<0.001), and to exhibit a greater surge in lymphocyte counts (627±465 cells/μl vs. 225±216 cells/ μl; P<0.05) during paradoxical response. Further studies on lymphocyte subsets and cytokine levels would be useful in understanding the exact immunological mechanisms involved in immunorestitution.
Persistent Identifierhttp://hdl.handle.net/10722/48642
ISSN
2013 Impact Factor: 2.544
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorLau, SKPen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorWong, SPYen_HK
dc.contributor.authorCheung, WCen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2008-05-22T04:19:50Z-
dc.date.available2008-05-22T04:19:50Z-
dc.date.issued2003en_HK
dc.identifier.citationEuropean Journal Of Clinical Microbiology And Infectious Diseases, 2003, v. 22 n. 10, p. 597-602en_HK
dc.identifier.issn0934-9723en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48642-
dc.description.abstractThe risk factors for development of paradoxical response were studied in a cohort of 104 patients with culture-documented Mycobacterium tuberculosis infection. Paradoxical deterioration occurred in 16 (15.4%) patients (case group) during antituberculosis therapy, involving lungs and pleura (n=4), spine and paraspinal tissue (n=5), intracranium (n=3), peritoneum (n=2), bone and joint (n=1), and lymph node (n=1). The median time from commencement of treatment to paradoxical deterioration was 56 days (range, 20-109 days). Compared with 53 patients without clinical deterioration after antituberculosis therapy (control group), patients with paradoxical response were more likely to have extrapulmonary involvement (62.5% vs. 17.0%; P<0.05) at initial diagnosis, to have lower baseline lymphocyte counts (672±315 cells/μl vs. 1,328±467 cells/μl; P<0.001), and to exhibit a greater surge in lymphocyte counts (627±465 cells/μl vs. 225±216 cells/ μl; P<0.05) during paradoxical response. Further studies on lymphocyte subsets and cytokine levels would be useful in understanding the exact immunological mechanisms involved in immunorestitution.en_HK
dc.format.extent122809 bytes-
dc.format.extent1902 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/10096/index.htmen_HK
dc.relation.ispartofEuropean Journal of Clinical Microbiology and Infectious Diseasesen_HK
dc.rightsThe original publication is available at www.springerlink.comen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectImmunocompromised Hosten_HK
dc.subjectBone Marrow Transplantation - immunologyen_HK
dc.subjectImmunosuppressive Agents - administration & dosageen_HK
dc.subjectLymphocyte Counten_HK
dc.titleRisk Factors for Development of Paradoxical Response During Antituberculosis Therapy in HIV-Negative Patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0934-9723&volume=22&issue=1&spage=597&epage=602&date=2003&atitle=Risk+factors+for+development+of+paradoxical+response+during+antituberculosis+therapy+in+HIV-negative+patientsen_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.emailLau, SKP:skplau@hkucc.hku.hken_HK
dc.identifier.emailHung, IFN:ivanhung@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityLau, SKP=rp00486en_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1007/s10096-003-0998-zen_HK
dc.identifier.pmid14508660en_HK
dc.identifier.scopuseid_2-s2.0-0242329701en_HK
dc.identifier.hkuros87975-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0242329701&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue10en_HK
dc.identifier.spage597en_HK
dc.identifier.epage602en_HK
dc.identifier.isiWOS:000186035600004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridLau, SKP=7401596211en_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridWong, SPY=7404589502en_HK
dc.identifier.scopusauthoridCheung, WC=7202743116en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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