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Article: Clinical deterioration in community acquired infections associated with lymphocyte upsurge in immunocompetent hosts

TitleClinical deterioration in community acquired infections associated with lymphocyte upsurge in immunocompetent hosts
Authors
Issue Date2004
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365548.asp
Citation
Scandinavian Journal Of Infectious Diseases, 2004, v. 36 n. 10, p. 743-751 How to Cite?
AbstractClinical deterioration during the course of community-acquired infections can occur as a result of an exaggerated immune response of the host towards the inciting pathogens, leading to immune-mediated tissue damage. Whether a surge in the peripheral lymphocyte count can be used as a surrogate marker indicating the onset of immunopathological tissue damage is not known. In this study, we report the clinical presentations and outcomes of a cohort of immunocompetent patients with non-tuberculous community acquired infections who experienced clinical deterioration during hospital stay (n=85). 12 (14.1%) patients had a surge in lymphocyte count preceding their clinical deteriorations, and their diagnoses included viral pneumonitis (4), viral encephalitis (3), scrub typhus (2), leptospirosis (1), brucellosis (1), and dengue haemorrhagic fever (1). The clinical manifestations during deterioration ranged from interstitial pneumonitis (6), airway obstruction (1), CNS disturbances (4), and systemic capillary leak syndrome (1), all of which were thought to represent immunopathological tissue damages. When compared with patients without lymphocyte surge, these patients were more likely to be infected with fastidious/viral pathogens (0 vs 12; p<0.05), in addition to having lower mean baseline lymphocyte counts (403±181 vs 1143±686 cells/μl; p<0.05). We postulate that the peripheral lymphocyte count may be a useful surrogate marker indicating the presence of immunopathological damage during clinical deterioration in certain infectious diseases. © 2004 Taylor & Francis.
Persistent Identifierhttp://hdl.handle.net/10722/48638
ISSN
2015 Impact Factor: 1.366
2015 SCImago Journal Rankings: 0.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorWu, AKLen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorTang, BSFen_HK
dc.contributor.authorLee, RAen_HK
dc.contributor.authorLau, SKPen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2008-05-22T04:19:45Z-
dc.date.available2008-05-22T04:19:45Z-
dc.date.issued2004en_HK
dc.identifier.citationScandinavian Journal Of Infectious Diseases, 2004, v. 36 n. 10, p. 743-751en_HK
dc.identifier.issn0036-5548en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48638-
dc.description.abstractClinical deterioration during the course of community-acquired infections can occur as a result of an exaggerated immune response of the host towards the inciting pathogens, leading to immune-mediated tissue damage. Whether a surge in the peripheral lymphocyte count can be used as a surrogate marker indicating the onset of immunopathological tissue damage is not known. In this study, we report the clinical presentations and outcomes of a cohort of immunocompetent patients with non-tuberculous community acquired infections who experienced clinical deterioration during hospital stay (n=85). 12 (14.1%) patients had a surge in lymphocyte count preceding their clinical deteriorations, and their diagnoses included viral pneumonitis (4), viral encephalitis (3), scrub typhus (2), leptospirosis (1), brucellosis (1), and dengue haemorrhagic fever (1). The clinical manifestations during deterioration ranged from interstitial pneumonitis (6), airway obstruction (1), CNS disturbances (4), and systemic capillary leak syndrome (1), all of which were thought to represent immunopathological tissue damages. When compared with patients without lymphocyte surge, these patients were more likely to be infected with fastidious/viral pathogens (0 vs 12; p<0.05), in addition to having lower mean baseline lymphocyte counts (403±181 vs 1143±686 cells/μl; p<0.05). We postulate that the peripheral lymphocyte count may be a useful surrogate marker indicating the presence of immunopathological damage during clinical deterioration in certain infectious diseases. © 2004 Taylor & Francis.en_HK
dc.format.extent157613 bytes-
dc.format.extent1902 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365548.aspen_HK
dc.relation.ispartofScandinavian Journal of Infectious Diseasesen_HK
dc.rightsScandinavian Journal of Infectious Diseases. Copyright © Informa Healthcare.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshImmunocompetenceen_HK
dc.subject.meshBacterial Infections - diagnosis - drug therapy - epidemiologyen_HK
dc.subject.meshCommunity-Acquired Infections - epidemiology - microbiology - physiopathologyen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.titleClinical deterioration in community acquired infections associated with lymphocyte upsurge in immunocompetent hostsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0036-5548&volume=36&issue=10&spage=743&epage=751&date=2004&atitle=Clinical+deterioration+in+community+acquired+infections+associated+with+lymphocyte+upsurge+in+immunocompetent+hostsen_HK
dc.identifier.emailHung, IFN:ivanhung@hkucc.hku.hken_HK
dc.identifier.emailLau, SKP:skplau@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityLau, SKP=rp00486en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1080/00365540410022602en_HK
dc.identifier.pmid15513401-
dc.identifier.scopuseid_2-s2.0-7944222796en_HK
dc.identifier.hkuros109680-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7944222796&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue10en_HK
dc.identifier.spage743en_HK
dc.identifier.epage751en_HK
dc.identifier.isiWOS:000224990100008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridWu, AKL=7402998681en_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridTang, BSF=8908243000en_HK
dc.identifier.scopusauthoridLee, RA=7408203830en_HK
dc.identifier.scopusauthoridLau, SKP=7401596211en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.citeulike12754-

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