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Article: An affected pedigree member analysis of linkage between the dopamine D2 receptor gene Taql polymorphism and obesity and hypertension

TitleAn affected pedigree member analysis of linkage between the dopamine D2 receptor gene Taql polymorphism and obesity and hypertension
Authors
KeywordsAffected pedigree member sib-pair analysis
Metabolic syndrome
Central obesity
Dopamine D2 receptor gene
Hypertension
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal of Cardiology, 2005, v. 102 n. 1, p. 111-116 How to Cite?
AbstractBACKGROUND: Dopamine modulates a variety of physiological functions including natriuresis and satiety. We have previously reported that the TaqI polymorphism of the dopamine D2 receptor (DD2R) gene is associated with both blood pressure and obesity indices in a normoglycaemic Hong Kong Chinese population. In this study, we present evidence confirming the linkage between this gene polymorphism, obesity and hypertension. METHODS: Two hundred and seventy-four siblings from 96 normoglycaemic hypertensive families were recruited, including 133 who were hypertensive. Central obesity was defined as a waist-to-hip ratio of > or = 0.9 and > or = 0.85 in males and females, respectively, and was identified in 99 of the siblings. The DD2R gene TaqI polymorphism was identified with a polymerase chain reaction based restriction fragment length polymorphism protocol. The affected pedigree member (APM) linkage analysis (sib-pair program, version 0.99.9, by D.L. Duffy) was used to assess for linkage between this gene polymorphism, obesity and hypertension in 73 families with siblings discordant for hypertension. RESULTS: The A1 allele frequencies were similar in the 133 hypertensive, and 141 normotensive siblings, including the 99 centrally obese siblings at 0.431, 0.421 and 0.418, respectively. APM linkage analysis suggested that the DD2R gene TaqI polymorphism had evidence of linkage with blood pressure (T = -1.86, P = 0.013), as well as with obesity (T = -1.58, P = 0.007). CONCLUSION: Our data in normoglycaemic Hong Kong Chinese supports that the DD2R gene TaqI polymorphism is a marker associated with the pathogenesis of obesity and hypertension.
Persistent Identifierhttp://hdl.handle.net/10722/48558
ISSN
2015 Impact Factor: 4.638
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFang, YJen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorXu, ZLen_HK
dc.contributor.authorFang, JQen_HK
dc.contributor.authorCritchley, JAJHen_HK
dc.contributor.authorTomlinson, Ben_HK
dc.date.accessioned2008-05-22T04:17:07Z-
dc.date.available2008-05-22T04:17:07Z-
dc.date.issued2005en_HK
dc.identifier.citationInternational Journal of Cardiology, 2005, v. 102 n. 1, p. 111-116en_HK
dc.identifier.issn0167-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48558-
dc.description.abstractBACKGROUND: Dopamine modulates a variety of physiological functions including natriuresis and satiety. We have previously reported that the TaqI polymorphism of the dopamine D2 receptor (DD2R) gene is associated with both blood pressure and obesity indices in a normoglycaemic Hong Kong Chinese population. In this study, we present evidence confirming the linkage between this gene polymorphism, obesity and hypertension. METHODS: Two hundred and seventy-four siblings from 96 normoglycaemic hypertensive families were recruited, including 133 who were hypertensive. Central obesity was defined as a waist-to-hip ratio of > or = 0.9 and > or = 0.85 in males and females, respectively, and was identified in 99 of the siblings. The DD2R gene TaqI polymorphism was identified with a polymerase chain reaction based restriction fragment length polymorphism protocol. The affected pedigree member (APM) linkage analysis (sib-pair program, version 0.99.9, by D.L. Duffy) was used to assess for linkage between this gene polymorphism, obesity and hypertension in 73 families with siblings discordant for hypertension. RESULTS: The A1 allele frequencies were similar in the 133 hypertensive, and 141 normotensive siblings, including the 99 centrally obese siblings at 0.431, 0.421 and 0.418, respectively. APM linkage analysis suggested that the DD2R gene TaqI polymorphism had evidence of linkage with blood pressure (T = -1.86, P = 0.013), as well as with obesity (T = -1.58, P = 0.007). CONCLUSION: Our data in normoglycaemic Hong Kong Chinese supports that the DD2R gene TaqI polymorphism is a marker associated with the pathogenesis of obesity and hypertension.en_HK
dc.format.extent67620 bytes-
dc.format.extent2502 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsInternational Journal of Cardiology. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAffected pedigree member sib-pair analysisen_HK
dc.subjectMetabolic syndromeen_HK
dc.subjectCentral obesityen_HK
dc.subjectDopamine D2 receptor geneen_HK
dc.subjectHypertensionen_HK
dc.titleAn affected pedigree member analysis of linkage between the dopamine D2 receptor gene Taql polymorphism and obesity and hypertensionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-5273&volume=102&issue=1&spage=111&epage=116&date=2005&atitle=An+affected+pedigree+member+analysis+of+linkage+between+the+dopamine+D2+receptor+gene+Taql+polymorphism+and+obesity+and+hypertensionen_HK
dc.identifier.emailThomas, GN: gneilthomas@yahoo.co.uken_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1016/j.ijcard.2004.05.010en_HK
dc.identifier.pmid15939106-
dc.identifier.scopuseid_2-s2.0-20444443561-
dc.identifier.hkuros98261-
dc.identifier.isiWOS:000229946100014-

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