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Article: Albuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patients

TitleAlbuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patients
Authors
KeywordsBlood pressure
Cardiovascular disease
Metabolic syndrome
Middle cerebral artery stenosis
Peripheral vascular disease
Issue Date2004
PublisherSpringer-Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
Citation
Diabetologia, 2004, v. 47 n. 9, p. 1528-1534 How to Cite?
AbstractAIMS/HYPOTHESIS: Albuminuria has been reported to be a marker of cardiovascular risk factors and disease morbidity and mortality, but its relationship with intracerebral atherosclerotic disease is less clear. The aim of this study was to investigate the association between albuminuria and intracranial and extracranial vascular involvement in Chinese Type 2 diabetic patients. METHODS: The anthropometric and fasting biochemical measurements of 966 Type 2 diabetic patients with normoalbuminuria (55.6%), microalbuminuria (27.7%) or macroalbuminuria (16.7%) were compared. The prevalence of microvascular and macrovascular disease and middle cerebral artery (MCA) stenosis, measured by transcranial Doppler ultrasound, were also compared between the groups. RESULTS: Albuminuria was closely associated with a range of adverse parameters, including high BP, dyslipidaemia, smoking and adiposity (all p<0.01). The prevalence of microvascular disease (retinopathy p<0.001) and macrovascular disease (peripheral vascular disease p=0.012, myocardial infarction, p=0.004, MCA stenosis p<0.001) increased significantly with increasing levels of albuminuria. Albuminuria was also found to be an independent predictor of microvascular and macrovascular disease. CONCLUSIONS/INTERPRETATION: Albuminuria was an independent predictor of increasing levels of vascular risk factors and microvascular and macrovascular disease in this group of Type 2 diabetic patients, and a possible role for albuminuria as a marker of intracranial cerebrovascular disease should be further investigated.
Persistent Identifierhttp://hdl.handle.net/10722/48555
ISSN
2015 Impact Factor: 6.206
2015 SCImago Journal Rankings: 3.528
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorLin, JWen_HK
dc.contributor.authorLam, WWMen_HK
dc.contributor.authorTomlinson, Ben_HK
dc.contributor.authorYeung, Ven_HK
dc.contributor.authorChan, JCNen_HK
dc.contributor.authorWong, KSen_HK
dc.date.accessioned2008-05-22T04:17:02Z-
dc.date.available2008-05-22T04:17:02Z-
dc.date.issued2004en_HK
dc.identifier.citationDiabetologia, 2004, v. 47 n. 9, p. 1528-1534en_HK
dc.identifier.issn0012-186Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/48555-
dc.description.abstractAIMS/HYPOTHESIS: Albuminuria has been reported to be a marker of cardiovascular risk factors and disease morbidity and mortality, but its relationship with intracerebral atherosclerotic disease is less clear. The aim of this study was to investigate the association between albuminuria and intracranial and extracranial vascular involvement in Chinese Type 2 diabetic patients. METHODS: The anthropometric and fasting biochemical measurements of 966 Type 2 diabetic patients with normoalbuminuria (55.6%), microalbuminuria (27.7%) or macroalbuminuria (16.7%) were compared. The prevalence of microvascular and macrovascular disease and middle cerebral artery (MCA) stenosis, measured by transcranial Doppler ultrasound, were also compared between the groups. RESULTS: Albuminuria was closely associated with a range of adverse parameters, including high BP, dyslipidaemia, smoking and adiposity (all p<0.01). The prevalence of microvascular disease (retinopathy p<0.001) and macrovascular disease (peripheral vascular disease p=0.012, myocardial infarction, p=0.004, MCA stenosis p<0.001) increased significantly with increasing levels of albuminuria. Albuminuria was also found to be an independent predictor of microvascular and macrovascular disease. CONCLUSIONS/INTERPRETATION: Albuminuria was an independent predictor of increasing levels of vascular risk factors and microvascular and macrovascular disease in this group of Type 2 diabetic patients, and a possible role for albuminuria as a marker of intracranial cerebrovascular disease should be further investigated.en_HK
dc.format.extent61966 bytes-
dc.format.extent2502 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherSpringer-Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htmen_HK
dc.rightsThe original publication is available at www.springerlink.comen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBlood pressureen_HK
dc.subjectCardiovascular diseaseen_HK
dc.subjectMetabolic syndromeen_HK
dc.subjectMiddle cerebral artery stenosisen_HK
dc.subjectPeripheral vascular diseaseen_HK
dc.titleAlbuminuria is a marker of increasing intracranial and extracranial vascular involvement in Type 2 diabetic Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-186X&volume=47&issue=9&spage=1528&epage=1534&date=2004&atitle=Albuminuria+is+a+marker+of+increasing+intracranial+and+extracranial+vascular+involvement+in+Type+2+diabetic+Chinese+patientsen_HK
dc.identifier.emailThomas, GN: gneilthomas@yahoo.co.uken_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1007/s00125-004-1490-8en_HK
dc.identifier.pmid15338128-
dc.identifier.scopuseid_2-s2.0-5644244991-
dc.identifier.hkuros95386-
dc.identifier.isiWOS:000224584700008-

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