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Article: Increasing severity of cardiovascular risk factors with increasing middle cerebral artery stenotic involvement in type 2 diabetic Chinese patients with asymptomatic cerebrovascular disease

TitleIncreasing severity of cardiovascular risk factors with increasing middle cerebral artery stenotic involvement in type 2 diabetic Chinese patients with asymptomatic cerebrovascular disease
Authors
Issue Date2004
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2004, v. 27 n. 5, p. 1121-1126 How to Cite?
AbstractOBJECTIVE: To identify determinants associated with increasing severity of middle cerebral artery (MCA) stenosis in asymptomatic Chinese type 2 diabetic patients with and without MCA stenosis determined using transcranial Doppler. Conventional risk factors contribute to the pathogenesis of ischemic stroke, and differences in the pattern of these may explain the heterogeneity of disease presentation in different populations. In Chinese patients, MCA stenosis is the most commonly identified intracranial vascular lesion. RESEARCH DESIGN AND METHODS: Anthropometric and fasting biochemical parameters were compared between type 2 diabetic patients with MCA stenosis in one (n = 185) or both (n = 200) vessels and 1,492 type 2 diabetic patients without evidence of stenosis. RESULTS: Increasing MCA stenotic vascular involvement was associated with significantly increasing age, duration of diabetes, systolic blood pressure, and LDL cholesterol, but with lower glucose levels. There was also an increased prevalence of hypertension, dyslipidemia, and use of blood pressure-and glucose-lowering agents in the patients with MCA stenosis. Concomitant significant increases in the prevalence of peripheral vascular disease and retinopathy were also observed in the patients with MCA stenosis. CONCLUSIONS: Transcranial Doppler examination identified stenosis in one or both MCAs in over one-fifth of the Chinese type 2 diabetic subjects without symptoms of cerebrovascular disease. A number of conventional cardiovascular risk factors were closely associated with MCA stenosis. This technique may allow the identification of a particularly high-risk group, and further studies are required to determine whether asymptomatic MCA stenosis is predictive of primary cerebrovascular events and whether intensive treatment of risk factors would reduce the risk.
Persistent Identifierhttp://hdl.handle.net/10722/48554
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorLin, JWen_HK
dc.contributor.authorLam, WWMen_HK
dc.contributor.authorTomlinson, Ben_HK
dc.contributor.authorYeung, Ven_HK
dc.contributor.authorChan, JCNen_HK
dc.contributor.authorLiu, Ren_HK
dc.contributor.authorWong, KSen_HK
dc.date.accessioned2008-05-22T04:17:01Z-
dc.date.available2008-05-22T04:17:01Z-
dc.date.issued2004en_HK
dc.identifier.citationDiabetes Care, 2004, v. 27 n. 5, p. 1121-1126en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48554-
dc.description.abstractOBJECTIVE: To identify determinants associated with increasing severity of middle cerebral artery (MCA) stenosis in asymptomatic Chinese type 2 diabetic patients with and without MCA stenosis determined using transcranial Doppler. Conventional risk factors contribute to the pathogenesis of ischemic stroke, and differences in the pattern of these may explain the heterogeneity of disease presentation in different populations. In Chinese patients, MCA stenosis is the most commonly identified intracranial vascular lesion. RESEARCH DESIGN AND METHODS: Anthropometric and fasting biochemical parameters were compared between type 2 diabetic patients with MCA stenosis in one (n = 185) or both (n = 200) vessels and 1,492 type 2 diabetic patients without evidence of stenosis. RESULTS: Increasing MCA stenotic vascular involvement was associated with significantly increasing age, duration of diabetes, systolic blood pressure, and LDL cholesterol, but with lower glucose levels. There was also an increased prevalence of hypertension, dyslipidemia, and use of blood pressure-and glucose-lowering agents in the patients with MCA stenosis. Concomitant significant increases in the prevalence of peripheral vascular disease and retinopathy were also observed in the patients with MCA stenosis. CONCLUSIONS: Transcranial Doppler examination identified stenosis in one or both MCAs in over one-fifth of the Chinese type 2 diabetic subjects without symptoms of cerebrovascular disease. A number of conventional cardiovascular risk factors were closely associated with MCA stenosis. This technique may allow the identification of a particularly high-risk group, and further studies are required to determine whether asymptomatic MCA stenosis is predictive of primary cerebrovascular events and whether intensive treatment of risk factors would reduce the risk.en_HK
dc.format.extent115686 bytes-
dc.format.extent2502 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association (ADA), publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at http://diabetes.diabetesjournals.org/en_HK
dc.subject.meshCardiovascular Diseases - epidemiology - physiopathologyen_HK
dc.subject.meshCerebral Arterial Diseases - epidemiology - physiopathologyen_HK
dc.subject.meshCerebrovascular Disorders - epidemiology - physiopathologyen_HK
dc.subject.meshDiabetic Angiopathies - epidemiology - physiopathologyen_HK
dc.subject.meshDiabetes Mellitus, Type 2en_HK
dc.titleIncreasing severity of cardiovascular risk factors with increasing middle cerebral artery stenotic involvement in type 2 diabetic Chinese patients with asymptomatic cerebrovascular diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0149-5992&volume=27&issue=5&spage=1121&epage=1126&date=2004&atitle=Increasing+severity+of+cardiovascular+risk+factors+with+increasing+middle+cerebral+artery+stenotic+involvement+in+type+2+diabetic+Chinese+patients+with+asymptomatic+cerebrovascular+diseaseen_HK
dc.identifier.emailThomas, GN: gneilthomas@yahoo.co.uken_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.2337/diacare.27.5.1121-
dc.identifier.pmid15111531-
dc.identifier.scopuseid_2-s2.0-2342616981-
dc.identifier.hkuros87894-
dc.identifier.isiWOS:000221157100018-

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