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Article: Association of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels

TitleAssociation of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels
Authors
KeywordsApolipoprotein A-I
Chinese
Hypertension
Lipids
Metabolic syndrome
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal of Cardiology, 2005, v. 102 n. 2, p. 309-314 How to Cite?
AbstractINTRODUCTION: Two MspI polymorphisms in the ApoA-I gene (G-75A and C83T) have been shown to be associated with plasma HDL-cholesterol levels. METHODS: We used a PCR-based RFLP method to determine the association of these polymorphisms with lipid parameters in 271 non-diabetic, normotriglyceridaemic Chinese subjects, of whom 104 were patients with hypertension, with 10.2% having hypercholesterolaemia and the remainder were controls. RESULTS: As expected, the hypertensive group had higher blood pressure and indices of obesity, and a more adverse lipid profile. No differences in the ApoA-I G-75A genotype or allele frequency distributions between the controls and patients were identified. However, there was a significantly lower frequency of the CT genotype (p=0.012) and T allele (p=0.011) in the affected subjects with hypercholesterolaemia or hypertension. Similarly, blood pressure and triglyceride levels were significantly lower and HDL-cholesterol levels significantly higher in the subjects with the CT genotype compared to those with the CC genotype (p<0.05). However, the G-75A genotypes did not appear to influence the lipid or blood pressure levels. The -75A allele frequency was higher in our healthy controls than an equivalent Caucasian population (31.1% vs. 18.3%, p<0.001), whereas the 83T allele frequency was similar between the healthy Chinese and Caucasian groups. CONCLUSION: The 83T allele may be associated with a better lipid profile and blood pressure levels in this group of Chinese subjects.
Persistent Identifierhttp://hdl.handle.net/10722/48547
ISSN
2015 Impact Factor: 4.638
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, YQen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorTomlinson, Ben_HK
dc.date.accessioned2008-05-22T04:16:51Z-
dc.date.available2008-05-22T04:16:51Z-
dc.date.issued2005en_HK
dc.identifier.citationInternational Journal of Cardiology, 2005, v. 102 n. 2, p. 309-314en_HK
dc.identifier.issn0167-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48547-
dc.description.abstractINTRODUCTION: Two MspI polymorphisms in the ApoA-I gene (G-75A and C83T) have been shown to be associated with plasma HDL-cholesterol levels. METHODS: We used a PCR-based RFLP method to determine the association of these polymorphisms with lipid parameters in 271 non-diabetic, normotriglyceridaemic Chinese subjects, of whom 104 were patients with hypertension, with 10.2% having hypercholesterolaemia and the remainder were controls. RESULTS: As expected, the hypertensive group had higher blood pressure and indices of obesity, and a more adverse lipid profile. No differences in the ApoA-I G-75A genotype or allele frequency distributions between the controls and patients were identified. However, there was a significantly lower frequency of the CT genotype (p=0.012) and T allele (p=0.011) in the affected subjects with hypercholesterolaemia or hypertension. Similarly, blood pressure and triglyceride levels were significantly lower and HDL-cholesterol levels significantly higher in the subjects with the CT genotype compared to those with the CC genotype (p<0.05). However, the G-75A genotypes did not appear to influence the lipid or blood pressure levels. The -75A allele frequency was higher in our healthy controls than an equivalent Caucasian population (31.1% vs. 18.3%, p<0.001), whereas the 83T allele frequency was similar between the healthy Chinese and Caucasian groups. CONCLUSION: The 83T allele may be associated with a better lipid profile and blood pressure levels in this group of Chinese subjects.en_HK
dc.format.extent59040 bytes-
dc.format.extent2502 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsInternational Journal of Cardiology. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectApolipoprotein A-Ien_HK
dc.subjectChineseen_HK
dc.subjectHypertensionen_HK
dc.subjectLipidsen_HK
dc.subjectMetabolic syndromeen_HK
dc.titleAssociation of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levelsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-5273&volume=102&issue=2&spage=309&epage=314&date=2005&atitle=Association+of+two+apolipoprotein+A-I+gene+MspI+polymorphisms+with+lipid+and+blood+pressure+levelsen_HK
dc.identifier.emailThomas, GN: gneilthomas@yahoo.co.uken_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1016/j.ijcard.2004.10.017en_HK
dc.identifier.pmid15982502-
dc.identifier.scopuseid_2-s2.0-20744452806-
dc.identifier.hkuros107095-
dc.identifier.isiWOS:000230556200022-

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