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Article: Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology
Title | Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology |
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Authors | |
Keywords | Neuroblastoma Tumor biomarkers Serum markers Protein profiling SELDI |
Issue Date | 2005 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35503 |
Citation | Journal of Cellular Biochemistry, 2005, v. 95 n. 1, p. 165-172 How to Cite? |
Abstract | Serological proteins of neuroblastoma were profiled and analyzed by ProteinChip-SELDI-TOF MS technology with five types of protein chips. By comparing with normal control, a number of protein or polypeptide signals were found significantly and consistently different in their intensities (expression levels) in tumor sera. Interestingly, nine polypeptide peaks in these proteomic features can be simultaneously detected with consistent variations by more than one type of protein chips. None of the expression differences of these nine polypeptides was found in similar comparisons between healthy controls and hepatomas. Preliminary protein identification showed hints for that some of these proteomic alterations may be closely related to the tumorigenesis of neuroblastoma. These results demonstrated the potential of serological biomarker identification for neuroblastoma by ProteinChip-SELDI technology. |
Persistent Identifier | http://hdl.handle.net/10722/48522 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.768 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | He, Q | en_HK |
dc.contributor.author | Zhu, R | en_HK |
dc.contributor.author | Ren, Y | en_HK |
dc.contributor.author | Tam, PKH | en_HK |
dc.contributor.author | Chiu, J | en_HK |
dc.date.accessioned | 2008-05-22T04:16:07Z | - |
dc.date.available | 2008-05-22T04:16:07Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Journal of Cellular Biochemistry, 2005, v. 95 n. 1, p. 165-172 | en_HK |
dc.identifier.issn | 0730-2312 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/48522 | - |
dc.description.abstract | Serological proteins of neuroblastoma were profiled and analyzed by ProteinChip-SELDI-TOF MS technology with five types of protein chips. By comparing with normal control, a number of protein or polypeptide signals were found significantly and consistently different in their intensities (expression levels) in tumor sera. Interestingly, nine polypeptide peaks in these proteomic features can be simultaneously detected with consistent variations by more than one type of protein chips. None of the expression differences of these nine polypeptides was found in similar comparisons between healthy controls and hepatomas. Preliminary protein identification showed hints for that some of these proteomic alterations may be closely related to the tumorigenesis of neuroblastoma. These results demonstrated the potential of serological biomarker identification for neuroblastoma by ProteinChip-SELDI technology. | en_HK |
dc.format.extent | 275767 bytes | - |
dc.format.extent | 254114 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/pdf | - |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35503 | en_HK |
dc.relation.ispartof | Journal Of Cellular Biochemistry | en_US |
dc.rights | Journal of Cellular Biochemistry. Copyright © John Wiley & Sons, Inc. | en_HK |
dc.subject | Neuroblastoma | en_HK |
dc.subject | Tumor biomarkers | en_HK |
dc.subject | Serum markers | en_HK |
dc.subject | Protein profiling | en_HK |
dc.subject | SELDI | en_HK |
dc.title | Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0730-2312&volume=95&issue=1&spage=165&epage=172&date=2005&atitle=Serological+protein+profiling+of+neuroblastoma+by+ProteinChip+SELDI-TOF+technology | en_HK |
dc.identifier.email | He, Q: qyhe@hkucc.hku.hk | en_HK |
dc.identifier.email | Zhu, R: laurence126@sina.com | en_HK |
dc.identifier.email | Ren, Y: yren@hkucc.hku.hk | en_HK |
dc.identifier.email | Tam, PKH: paultam@hkucc.hku.hk | en_HK |
dc.identifier.email | Chiu, J: jfchiu@hkucc.hku.hk | en_HK |
dc.identifier.authority | Tam, PKH=rp00060 | en_US |
dc.description.nature | postprint | en_HK |
dc.identifier.doi | 10.1002/jcb.20417 | en_HK |
dc.identifier.pmid | 15759280 | en_HK |
dc.identifier.scopus | eid_2-s2.0-23844433345 | en_US |
dc.identifier.hkuros | 97771 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-23844433345&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 95 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 165 | en_US |
dc.identifier.epage | 172 | en_US |
dc.identifier.isi | WOS:000228744000017 | - |
dc.identifier.issnl | 0730-2312 | - |