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Article: The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome

TitleThe use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome
Authors
Keywordsα1-antitrypsin
Biomarker
Complement 4
Serum amyloid A
Severe acute respiratory syndrome
Issue Date2004
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics
Citation
Proteomics, 2004, v. 4 n. 11, p. 3477-3484 How to Cite?
AbstractSevere acute respiratory syndrome (SARS) is a new infectious disease with a global impact. Understanding its pathogenesis and developing specific diagnostic methods for its early diagnosis are crucial for the effective management and control of this disease. By using proteomic technology, truncated forms of α1-antitrypsin (TF-α1-AT) were found to increase significantly and consistently in sera of SARS patients compared to control subjects. The result showed a sensitivity of 100% for SARS patients and a specificity of 92.8% for controls. Furthermore, the levels of these proteins significantly correlated with certain clinico-pathological parameters. The dramatic increase in TF-α1-AT may be the result of degradation of α1-AT. As α1-AT plays an important role in the protection of lung function, its degradation may be an important factor in the pathogenesis of SARS. These findings indicate that increased TF-α1-AT may be therapeutically relevant, and may also be a useful biological marker for the diagnosis of SARS.
Persistent Identifierhttp://hdl.handle.net/10722/48521
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRen, Yen_HK
dc.contributor.authorHe, QYen_HK
dc.contributor.authorFan, Jen_HK
dc.contributor.authorJones, Ben_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorXie, Yen_HK
dc.contributor.authorCheung, CYen_HK
dc.contributor.authorWu, Aen_HK
dc.contributor.authorChiu, JFen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2008-05-22T04:16:06Z-
dc.date.available2008-05-22T04:16:06Z-
dc.date.issued2004en_HK
dc.identifier.citationProteomics, 2004, v. 4 n. 11, p. 3477-3484en_HK
dc.identifier.issn1615-9853en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48521-
dc.description.abstractSevere acute respiratory syndrome (SARS) is a new infectious disease with a global impact. Understanding its pathogenesis and developing specific diagnostic methods for its early diagnosis are crucial for the effective management and control of this disease. By using proteomic technology, truncated forms of α1-antitrypsin (TF-α1-AT) were found to increase significantly and consistently in sera of SARS patients compared to control subjects. The result showed a sensitivity of 100% for SARS patients and a specificity of 92.8% for controls. Furthermore, the levels of these proteins significantly correlated with certain clinico-pathological parameters. The dramatic increase in TF-α1-AT may be the result of degradation of α1-AT. As α1-AT plays an important role in the protection of lung function, its degradation may be an important factor in the pathogenesis of SARS. These findings indicate that increased TF-α1-AT may be therapeutically relevant, and may also be a useful biological marker for the diagnosis of SARS.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomicsen_HK
dc.relation.ispartofProteomicsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectα1-antitrypsinen_HK
dc.subjectBiomarkeren_HK
dc.subjectComplement 4en_HK
dc.subjectSerum amyloid Aen_HK
dc.subjectSevere acute respiratory syndromeen_HK
dc.titleThe use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=4&issue=11&spage=3477&epage=3484&date=2004&atitle=The+use+of+proteomics+in+the+discovery+of+serum+biomarkers+from+patients+with+severe+acute+respiratory+syndromeen_HK
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.authorityCheung, CY=rp00404en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1002/pmic.200400897en_HK
dc.identifier.pmid15378763-
dc.identifier.scopuseid_2-s2.0-8744310559en_HK
dc.identifier.hkuros96648-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8744310559&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue11en_HK
dc.identifier.spage3477en_HK
dc.identifier.epage3484en_HK
dc.identifier.isiWOS:000225223200023-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridRen, Y=8109150500en_HK
dc.identifier.scopusauthoridHe, QY=34770287900en_HK
dc.identifier.scopusauthoridFan, J=7402794720en_HK
dc.identifier.scopusauthoridJones, B=7404958958en_HK
dc.identifier.scopusauthoridZhou, Y=7405366890en_HK
dc.identifier.scopusauthoridXie, Y=7403958906en_HK
dc.identifier.scopusauthoridCheung, CY=7202061836en_HK
dc.identifier.scopusauthoridWu, A=7402998620en_HK
dc.identifier.scopusauthoridChiu, JF=7201501692en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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