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Article: Proteomics of buccal squamous cell carcinoma: The involvement of multiple pathways in tumorigenesis

TitleProteomics of buccal squamous cell carcinoma: The involvement of multiple pathways in tumorigenesis
Authors
KeywordsBiomarker
Buccal cancer
Mass spectronomyi fingerprinting
Protein profile
Two-dimensional-polyacrylamide get dectrophoresis
Issue Date2004
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics
Citation
Proteomics, 2004, v. 4 n. 8, p. 2465-2475 How to Cite?
AbstractSquamous cell carcinoma (SCC) of the buccal mucosa is an aggressive oral cancer. It mainly occurs in Central and Southeast Asia, and is closely related to the practice of tobacco smoking and betel squid chewing. The high recurrence and low survival rates of buccal SCC require our continued efforts to understand the pathogenesis of the disease for designing better therapeutic strategies. We used proteomic technology to analyze buccal SCC tissues aiming at identifying tumor-associated proteins for the utilization as biomarkers or molecular targets. With the exception of alpha B-crystallin being substantially reduced, a number of proteins were found to be significantly over-expressed in cancer tissues. These increased proteins included glycolytic enzymes, heat-shock proteins, tumor antigens, cytoskeleton proteins, enzymes involved in detoxification and anti-oxidation systems, and proteins involved in mitochondrial and intracellular signaling pathways. These extensive protein variations indicate that multiple cellular pathways were involved in the process of tumorigenesis, and suggest that multiple protein molecules should be simultaneously targeted as an effective strategy to counter the disease. At least, SCC antigen, G protein, glutathione S-transferase, manganese superoxide dismutase, annexins, voltage-dependent anion channel, cyclophilin A, stratifin and galectin 7 are candidates for targeted proteins. The present findings also demonstrated that rich protein information can be produced by means of proteomic analysis for a better understanding of the oncogenesis and pathogenesis in a global way, which in turn is a basis for the rational designs of diagnostic and therapeutic methods.
Persistent Identifierhttp://hdl.handle.net/10722/48518
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Jen_HK
dc.contributor.authorHe, Qen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorChiu, Jen_HK
dc.date.accessioned2008-05-22T04:16:02Z-
dc.date.available2008-05-22T04:16:02Z-
dc.date.issued2004en_HK
dc.identifier.citationProteomics, 2004, v. 4 n. 8, p. 2465-2475en_HK
dc.identifier.issn1615-9853en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48518-
dc.description.abstractSquamous cell carcinoma (SCC) of the buccal mucosa is an aggressive oral cancer. It mainly occurs in Central and Southeast Asia, and is closely related to the practice of tobacco smoking and betel squid chewing. The high recurrence and low survival rates of buccal SCC require our continued efforts to understand the pathogenesis of the disease for designing better therapeutic strategies. We used proteomic technology to analyze buccal SCC tissues aiming at identifying tumor-associated proteins for the utilization as biomarkers or molecular targets. With the exception of alpha B-crystallin being substantially reduced, a number of proteins were found to be significantly over-expressed in cancer tissues. These increased proteins included glycolytic enzymes, heat-shock proteins, tumor antigens, cytoskeleton proteins, enzymes involved in detoxification and anti-oxidation systems, and proteins involved in mitochondrial and intracellular signaling pathways. These extensive protein variations indicate that multiple cellular pathways were involved in the process of tumorigenesis, and suggest that multiple protein molecules should be simultaneously targeted as an effective strategy to counter the disease. At least, SCC antigen, G protein, glutathione S-transferase, manganese superoxide dismutase, annexins, voltage-dependent anion channel, cyclophilin A, stratifin and galectin 7 are candidates for targeted proteins. The present findings also demonstrated that rich protein information can be produced by means of proteomic analysis for a better understanding of the oncogenesis and pathogenesis in a global way, which in turn is a basis for the rational designs of diagnostic and therapeutic methods.en_HK
dc.format.extent970320 bytes-
dc.format.extent254114 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomicsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsPublished in Proteomics, 2004, v. 4 n. 8, p. 2465-2475en_HK
dc.subjectBiomarkeren_HK
dc.subjectBuccal canceren_HK
dc.subjectMass spectronomyi fingerprintingen_HK
dc.subjectProtein profileen_HK
dc.subjectTwo-dimensional-polyacrylamide get dectrophoresisen_HK
dc.titleProteomics of buccal squamous cell carcinoma: The involvement of multiple pathways in tumorigenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=4&issue=8&spage=2465&epage=2475&date=2004&atitle=Proteomics+of+buccal+squamous+cell+carcinoma:+The+involvement+of+multiple+pathways+in+tumorigenesisen_HK
dc.identifier.emailHe, Q: qyhe@hkucc.hku.hken_HK
dc.identifier.emailYuen, PW: pwyuen@hkucc.hku.hken_HK
dc.identifier.emailChiu, J: jfchiu@hkucc.hku.hken_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1002/pmic.200300762en_HK
dc.identifier.pmid15274141-
dc.identifier.scopuseid_2-s2.0-3543055313-
dc.identifier.hkuros91291-
dc.identifier.isiWOS:000223137300029-
dc.identifier.citeulike2625467-

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