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Article: Serum biomarkers of hepatitis B virus infected liver inflammation: A proteomic study

TitleSerum biomarkers of hepatitis B virus infected liver inflammation: A proteomic study
Authors
KeywordsLiver disease
Liver infection
Protein profile
Serological proteins
Two-dimensional gel electrophoresis PRO 0394
Issue Date2003
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics
Citation
Proteomics, 2003, v. 3 n. 5, p. 666-674 How to Cite?
AbstractHepatitis B virus (HBV), a serious infectious and widespread human pathogen, represents a major health problem worldwide. Chronic HBV infection has a very high risk of evolving into hepatocellular carcinoma. Although considerable progress was made during the recent past, the pathogenesis of HBV infection is still elusive and a definite diagnosis of HBV infected liver information still relies on biopsy histological test. In this report, we used proteomics technology to globally examine HBV infected serum samples aiming at searching for disease-associated proteins that can be used as serological biomarkers for diagnosis and/or target proteins for pathogenetic study. By comparing with normal and HBV negative serum samples, we found that at least seven proteins were significantly changed in HBV infected sera. These greatly altered proteins were identified to be haptoglobin β and α2 chain, apolipoprotein A-I and A-IV, α1-antitrypsin, transthyretin and DNA topoisomerase IIβ. The alteration of these proteins is displayed not only in quantity but also in patterns (or specificity), which can be correlated with necroinflammatory scores. In particular, apolipoprotein A-I presents heterogeneous change in expression level with different isoforms and $1-antitrypsin produces evidently different fragments implying diverse cleavage pathways. These unique phenomena appear specific to HBV infection. A combination simultaneously considering the quantities and isoforms of these proteins could be a useful serum biomarker (or index) for HBV diagnosis and therapy.
Persistent Identifierhttp://hdl.handle.net/10722/48515
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHe, QYen_HK
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLin, MCen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorChiu, JFen_HK
dc.date.accessioned2008-05-22T04:15:57Z-
dc.date.available2008-05-22T04:15:57Z-
dc.date.issued2003en_HK
dc.identifier.citationProteomics, 2003, v. 3 n. 5, p. 666-674en_HK
dc.identifier.issn1615-9853en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48515-
dc.description.abstractHepatitis B virus (HBV), a serious infectious and widespread human pathogen, represents a major health problem worldwide. Chronic HBV infection has a very high risk of evolving into hepatocellular carcinoma. Although considerable progress was made during the recent past, the pathogenesis of HBV infection is still elusive and a definite diagnosis of HBV infected liver information still relies on biopsy histological test. In this report, we used proteomics technology to globally examine HBV infected serum samples aiming at searching for disease-associated proteins that can be used as serological biomarkers for diagnosis and/or target proteins for pathogenetic study. By comparing with normal and HBV negative serum samples, we found that at least seven proteins were significantly changed in HBV infected sera. These greatly altered proteins were identified to be haptoglobin β and α2 chain, apolipoprotein A-I and A-IV, α1-antitrypsin, transthyretin and DNA topoisomerase IIβ. The alteration of these proteins is displayed not only in quantity but also in patterns (or specificity), which can be correlated with necroinflammatory scores. In particular, apolipoprotein A-I presents heterogeneous change in expression level with different isoforms and $1-antitrypsin produces evidently different fragments implying diverse cleavage pathways. These unique phenomena appear specific to HBV infection. A combination simultaneously considering the quantities and isoforms of these proteins could be a useful serum biomarker (or index) for HBV diagnosis and therapy.en_HK
dc.format.extent100033 bytes-
dc.format.extent254114 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomicsen_HK
dc.relation.ispartofProteomicsen_HK
dc.subjectLiver diseaseen_HK
dc.subjectLiver infectionen_HK
dc.subjectProtein profileen_HK
dc.subjectSerological proteinsen_HK
dc.subjectTwo-dimensional gel electrophoresis PRO 0394en_HK
dc.titleSerum biomarkers of hepatitis B virus infected liver inflammation: A proteomic studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=3&issue=5&spage=666&epage=674&date=2003&atitle=Serum+biomarkers+of+hepatitis+B+virus+infected+liver+inflammation:+a+proteomic+studyen_HK
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltexten_HK
dc.identifier.doi10.1002/pmic.200300394en_HK
dc.identifier.pmid12748946-
dc.identifier.scopuseid_2-s2.0-0037541161en_HK
dc.identifier.hkuros79107-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037541161&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue5en_HK
dc.identifier.spage666en_HK
dc.identifier.epage674en_HK
dc.identifier.isiWOS:000182937000010-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridHe, QY=34770287900en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridZhou, Y=7405366890en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridLin, MC=7404816359en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridChiu, JF=7201501692en_HK

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