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Article: Proteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drug

TitleProteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drug
Authors
KeywordsAnticancer drug
Apoptosis
Gold compound
Protein profiling
Issue Date2006
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomics
Citation
Proteomics, 2006, v. 6 n. 1, p. 131-142 How to Cite?
AbstractThere has been increasing interest in the potential applications of gold (III) complexes as anticancer drugs with higher cytotoxicity and fewer side effects than existing metal anticancer drugs. Our previous findings demonstrated that gold (III) porphyrin la preferentially induced apoptosis in a cancer cell line (SUNE1). In this study, we identified differentially expressed proteins related to the drug's cytotoxic action by comparing the protein alterations induced by gold (III) porphyrin la and cisplatin treatments. Several clusters of altered proteins were identified, including cellular structure and stress-related chaperone proteins, proteins involved in reactive oxygen species and enzyme proteins, translation factors, proteins that mediate cell proliferation or differentiation, and proteins participating in the internal degradation systems. Our results indicated that multiple factors leading to apoptosis were involved in drug cytotoxicity in SUNE1 cells. The balance between pro-apoptotic and anti-apoptotic signals determined the final fate of cancer cells. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/48512
ISSN
2015 Impact Factor: 4.079
2015 SCImago Journal Rankings: 1.476
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorHe, QYen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorChiu, JFen_HK
dc.date.accessioned2008-05-22T04:15:53Z-
dc.date.available2008-05-22T04:15:53Z-
dc.date.issued2006en_HK
dc.identifier.citationProteomics, 2006, v. 6 n. 1, p. 131-142en_HK
dc.identifier.issn1615-9853en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48512-
dc.description.abstractThere has been increasing interest in the potential applications of gold (III) complexes as anticancer drugs with higher cytotoxicity and fewer side effects than existing metal anticancer drugs. Our previous findings demonstrated that gold (III) porphyrin la preferentially induced apoptosis in a cancer cell line (SUNE1). In this study, we identified differentially expressed proteins related to the drug's cytotoxic action by comparing the protein alterations induced by gold (III) porphyrin la and cisplatin treatments. Several clusters of altered proteins were identified, including cellular structure and stress-related chaperone proteins, proteins involved in reactive oxygen species and enzyme proteins, translation factors, proteins that mediate cell proliferation or differentiation, and proteins participating in the internal degradation systems. Our results indicated that multiple factors leading to apoptosis were involved in drug cytotoxicity in SUNE1 cells. The balance between pro-apoptotic and anti-apoptotic signals determined the final fate of cancer cells. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.format.extent1738507 bytes-
dc.format.extent254114 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/proteomicsen_HK
dc.relation.ispartofProteomicsen_HK
dc.rightsPublished in Proteomics, 2006, v. 6 n. 1, p. 131-142en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAnticancer drugen_HK
dc.subjectApoptosisen_HK
dc.subjectGold compounden_HK
dc.subjectProtein profilingen_HK
dc.titleProteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drugen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1615-9853&volume=6&issue=1&spage=131&epage=142&date=2006&atitle=Proteomic+characterization+of+the+cytotoxic+mechanism+of+gold+(III)+porphyrin+1a,+a+potential+anticancer+drugen_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1002/pmic.200402027en_HK
dc.identifier.pmid16287165en_HK
dc.identifier.scopuseid_2-s2.0-31344472931en_HK
dc.identifier.hkuros113901-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-31344472931&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue1en_HK
dc.identifier.spage131en_HK
dc.identifier.epage142en_HK
dc.identifier.isiWOS:000234764800014-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridWang, Y=7601510411en_HK
dc.identifier.scopusauthoridHe, QY=34770287900en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridChiu, JF=7201501692en_HK

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