Article: Ciliary central microtubular orientation is of no clinical significance in bronchiectasis

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TitleCiliary central microtubular orientation is of no clinical significance in bronchiectasis
AuthorsTsang, KW1
Tipoe, GL1
Mak, JC1
Sun, J1
Wong, M1
Leung, R1
Tan, KC1
MedStat, CKM1
Ho, JC1
Ho, PL1
Rutman, A2
Lam, WK1
KeywordsBronchiectasis
Cilia
Ciliary central microtubular orientation
Transmission electronic microscopy
Issue Date2005
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
CitationRespiratory Medicine, 2005, v. 99 n. 3, p. 290-297 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.rmed.2004.08.005
AbstractIt has been suggested that patients with bronchiectasis might have increased central microtubular orientation angle (CMOA), which leads to poor coordination of ciliary beating, and consequently impairment of airway defence. We have employed transmission electron microscopy to assess CMOA of ciliated nasal mucosa in a cohort of 133 (81F, 56.8±16.1 yr) stable bronchiectasis and 59 healthy subjects (30F, 49.3±22.1 yr). There was no significant difference in CMOA between bronchiectasis (13.2 degree) and control subjects (13.0 degree, P = 0.82). There was no significant difference in CMOA among patients according to the etiology of bronchiectasis, presence of nasal symptoms, or sputum status of Pseudomonas aeruginosa infection. Patients with more severe bronchiectasis, i.e. those with FEV 1 <60%, FVC <60%, or more than 4 bronchiectatic lung lobes, had significantly lower CMOA than their counterparts (P < 0.05). There was no correlation between CMOA with age, 24 h sputum volume, exacerbation frequency, FEV 1, FVC, or the number of bronchiectatic lung lobes (P > 0.05). CMOA correlated with ciliary beat frequency (negative), and the percent of cilia showing ultrastructural or microtubular defects (P < 0.05). Central microtubular orientation angle does not correlate with clinically important parameters, in contrary to the results reported by previously published smaller scale studies. © 2004 Elsevier Ltd. All rights reserved.
ISSN0954-6111
2011 Impact Factor: 2.475
2011 SCImago Journal Rankings: 0.213
DOIhttp://dx.doi.org/10.1016/j.rmed.2004.08.005
ISI Accession Number IDWOS:000227296600007
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTsang, KW
dc.contributor.authorTipoe, GL
dc.contributor.authorMak, JC
dc.contributor.authorSun, J
dc.contributor.authorWong, M
dc.contributor.authorLeung, R
dc.contributor.authorTan, KC
dc.contributor.authorMedStat, CKM
dc.contributor.authorHo, JC
dc.contributor.authorHo, PL
dc.contributor.authorRutman, A
dc.contributor.authorLam, WK
dc.date.accessioned2008-05-22T04:15:20Z
dc.date.available2008-05-22T04:15:20Z
dc.date.issued2005
dc.description.abstractIt has been suggested that patients with bronchiectasis might have increased central microtubular orientation angle (CMOA), which leads to poor coordination of ciliary beating, and consequently impairment of airway defence. We have employed transmission electron microscopy to assess CMOA of ciliated nasal mucosa in a cohort of 133 (81F, 56.8±16.1 yr) stable bronchiectasis and 59 healthy subjects (30F, 49.3±22.1 yr). There was no significant difference in CMOA between bronchiectasis (13.2 degree) and control subjects (13.0 degree, P = 0.82). There was no significant difference in CMOA among patients according to the etiology of bronchiectasis, presence of nasal symptoms, or sputum status of Pseudomonas aeruginosa infection. Patients with more severe bronchiectasis, i.e. those with FEV 1 <60%, FVC <60%, or more than 4 bronchiectatic lung lobes, had significantly lower CMOA than their counterparts (P < 0.05). There was no correlation between CMOA with age, 24 h sputum volume, exacerbation frequency, FEV 1, FVC, or the number of bronchiectatic lung lobes (P > 0.05). CMOA correlated with ciliary beat frequency (negative), and the percent of cilia showing ultrastructural or microtubular defects (P < 0.05). Central microtubular orientation angle does not correlate with clinically important parameters, in contrary to the results reported by previously published smaller scale studies. © 2004 Elsevier Ltd. All rights reserved.
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dc.identifier.citationRespiratory Medicine, 2005, v. 99 n. 3, p. 290-297 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.rmed.2004.08.005
dc.identifier.doihttp://dx.doi.org/10.1016/j.rmed.2004.08.005
dc.identifier.epage297
dc.identifier.hkuros97629
dc.identifier.isiWOS:000227296600007
dc.identifier.issn0954-6111
2011 Impact Factor: 2.475
2011 SCImago Journal Rankings: 0.213
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid15733504
dc.identifier.scopuseid_2-s2.0-20944433536
dc.identifier.spage290
dc.identifier.urihttp://hdl.handle.net/10722/48498
dc.identifier.volume99
dc.languageeng
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
dc.publisher.placeUnited Kingdom
dc.relation.ispartofRespiratory Medicine
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectBronchiectasis
dc.subjectCilia
dc.subjectCiliary central microtubular orientation
dc.subjectTransmission electronic microscopy
dc.titleCiliary central microtubular orientation is of no clinical significance in bronchiectasis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. University of Leicester