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Article: Ciliary central microtubular orientation is of no clinical significance in bronchiectasis
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TitleCiliary central microtubular orientation is of no clinical significance in bronchiectasis
 
AuthorsTsang, KW1
Tipoe, GL1
Mak, JC1
Sun, J1
Wong, M1
Leung, R1
Tan, KC1
MedStat, CKM1
Ho, JC1
Ho, PL1
Rutman, A2
Lam, WK1
 
KeywordsBronchiectasis
Cilia
Ciliary central microtubular orientation
Transmission electronic microscopy
 
Issue Date2005
 
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
 
CitationRespiratory Medicine, 2005, v. 99 n. 3, p. 290-297 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.rmed.2004.08.005
 
AbstractIt has been suggested that patients with bronchiectasis might have increased central microtubular orientation angle (CMOA), which leads to poor coordination of ciliary beating, and consequently impairment of airway defence. We have employed transmission electron microscopy to assess CMOA of ciliated nasal mucosa in a cohort of 133 (81F, 56.8±16.1 yr) stable bronchiectasis and 59 healthy subjects (30F, 49.3±22.1 yr). There was no significant difference in CMOA between bronchiectasis (13.2 degree) and control subjects (13.0 degree, P = 0.82). There was no significant difference in CMOA among patients according to the etiology of bronchiectasis, presence of nasal symptoms, or sputum status of Pseudomonas aeruginosa infection. Patients with more severe bronchiectasis, i.e. those with FEV 1 <60%, FVC <60%, or more than 4 bronchiectatic lung lobes, had significantly lower CMOA than their counterparts (P < 0.05). There was no correlation between CMOA with age, 24 h sputum volume, exacerbation frequency, FEV 1, FVC, or the number of bronchiectatic lung lobes (P > 0.05). CMOA correlated with ciliary beat frequency (negative), and the percent of cilia showing ultrastructural or microtubular defects (P < 0.05). Central microtubular orientation angle does not correlate with clinically important parameters, in contrary to the results reported by previously published smaller scale studies. © 2004 Elsevier Ltd. All rights reserved.
 
ISSN0954-6111
2012 Impact Factor: 2.585
2012 SCImago Journal Rankings: 1.055
 
DOIhttp://dx.doi.org/10.1016/j.rmed.2004.08.005
 
ISI Accession Number IDWOS:000227296600007
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTsang, KW
 
dc.contributor.authorTipoe, GL
 
dc.contributor.authorMak, JC
 
dc.contributor.authorSun, J
 
dc.contributor.authorWong, M
 
dc.contributor.authorLeung, R
 
dc.contributor.authorTan, KC
 
dc.contributor.authorMedStat, CKM
 
dc.contributor.authorHo, JC
 
dc.contributor.authorHo, PL
 
dc.contributor.authorRutman, A
 
dc.contributor.authorLam, WK
 
dc.date.accessioned2008-05-22T04:15:20Z
 
dc.date.available2008-05-22T04:15:20Z
 
dc.date.issued2005
 
dc.description.abstractIt has been suggested that patients with bronchiectasis might have increased central microtubular orientation angle (CMOA), which leads to poor coordination of ciliary beating, and consequently impairment of airway defence. We have employed transmission electron microscopy to assess CMOA of ciliated nasal mucosa in a cohort of 133 (81F, 56.8±16.1 yr) stable bronchiectasis and 59 healthy subjects (30F, 49.3±22.1 yr). There was no significant difference in CMOA between bronchiectasis (13.2 degree) and control subjects (13.0 degree, P = 0.82). There was no significant difference in CMOA among patients according to the etiology of bronchiectasis, presence of nasal symptoms, or sputum status of Pseudomonas aeruginosa infection. Patients with more severe bronchiectasis, i.e. those with FEV 1 <60%, FVC <60%, or more than 4 bronchiectatic lung lobes, had significantly lower CMOA than their counterparts (P < 0.05). There was no correlation between CMOA with age, 24 h sputum volume, exacerbation frequency, FEV 1, FVC, or the number of bronchiectatic lung lobes (P > 0.05). CMOA correlated with ciliary beat frequency (negative), and the percent of cilia showing ultrastructural or microtubular defects (P < 0.05). Central microtubular orientation angle does not correlate with clinically important parameters, in contrary to the results reported by previously published smaller scale studies. © 2004 Elsevier Ltd. All rights reserved.
 
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dc.identifier.citationRespiratory Medicine, 2005, v. 99 n. 3, p. 290-297 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.rmed.2004.08.005
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.rmed.2004.08.005
 
dc.identifier.epage297
 
dc.identifier.hkuros97629
 
dc.identifier.isiWOS:000227296600007
 
dc.identifier.issn0954-6111
2012 Impact Factor: 2.585
2012 SCImago Journal Rankings: 1.055
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid15733504
 
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dc.identifier.spage290
 
dc.identifier.urihttp://hdl.handle.net/10722/48498
 
dc.identifier.volume99
 
dc.languageeng
 
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofRespiratory Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectBronchiectasis
 
dc.subjectCilia
 
dc.subjectCiliary central microtubular orientation
 
dc.subjectTransmission electronic microscopy
 
dc.titleCiliary central microtubular orientation is of no clinical significance in bronchiectasis
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. University of Leicester