Published Patent: Chimeric Antisense Oligonucleotides Of Arabinofuranose Analogue And Deoxyribose Nucleotides
| Title | Chimeric Antisense Oligonucleotides Of Arabinofuranose Analogue And Deoxyribose Nucleotides |
|---|---|
| Priority Date | 2001-09-04 PCT/CA2001001252 2000-09-06 US 09/230414P |
| Inventors | Lok, CN Damha, MJ Parniak, MA Viazovkina, E |
| Citation | US Published patent application 20040038399. Washington, DC: US Patent and Trademark Office (USPTO), 2004 [How to Cite?] |
| Abstract | The Present Invention Relates To Novel Oligonucleotide Chimera Used As Therapeutic Agents To Selectively Prevent Gene Transcription And Expression In A Sequence-Specific Manner. In Particular, This Invention Is Directed To The Selective Inhibition Of Protein Biosynthesis Via Antisense Strategy Using Oligonucleotides Constructed From Arabinonucleotide Or Modified Arabinonucleotide Residues, Flanking A Series Of Deoxyribose Nucleotide Residues Of Variable Length. Particularly This Invention Relates To The Use Of Antisense Oligonucleotides Constructed From Arabinonucleotide Or Modified Arabinonucleotide Residues, Flanking A Series Of Deoxyribose Nucleotide Residues Of Variable Length, To Hybridize To Complementary Rna Such As Cellular Messenger Rna, Viral Rna, Etc.; More Particularly This Invention Relates To The Use Of Antisense Oligonucleotides Constructed From Arabinonucleotide Or Modified Arabinonucleotide Residues, Flanking A Series Of Deoxyribose Nucleotide Residues Of Variable Length, To Hybridize To And Induce Cleavage Of (Via Rnaseh Activation) The Complementary Rna. |
| dc.contributor.inventor | Lok, CN |
|---|---|
| dc.contributor.inventor | Damha, MJ |
| dc.contributor.inventor | Parniak, MA |
| dc.contributor.inventor | Viazovkina, E |
| dc.date.accessioned | 2007-10-30T07:04:14Z |
| patents.date.application | 2003-06-13 |
| dc.date.available | 2007-10-30T07:04:14Z |
| patents.date.priority | 2001-09-04 PCT/CA2001001252 |
| patents.date.priority | 2000-09-06 US 09/230414P |
| patents.date.publication | 2004-02-26 |
| dc.description.abstract | The Present Invention Relates To Novel Oligonucleotide Chimera Used As Therapeutic Agents To Selectively Prevent Gene Transcription And Expression In A Sequence-Specific Manner. In Particular, This Invention Is Directed To The Selective Inhibition Of Protein Biosynthesis Via Antisense Strategy Using Oligonucleotides Constructed From Arabinonucleotide Or Modified Arabinonucleotide Residues, Flanking A Series Of Deoxyribose Nucleotide Residues Of Variable Length. Particularly This Invention Relates To The Use Of Antisense Oligonucleotides Constructed From Arabinonucleotide Or Modified Arabinonucleotide Residues, Flanking A Series Of Deoxyribose Nucleotide Residues Of Variable Length, To Hybridize To Complementary Rna Such As Cellular Messenger Rna, Viral Rna, Etc.; More Particularly This Invention Relates To The Use Of Antisense Oligonucleotides Constructed From Arabinonucleotide Or Modified Arabinonucleotide Residues, Flanking A Series Of Deoxyribose Nucleotide Residues Of Variable Length, To Hybridize To And Induce Cleavage Of (Via Rnaseh Activation) The Complementary Rna. |
| patents.description.assignee | Damha Masad Jose, ; Parniak Michael A, ; Lok Chun-Nam, ; Viazovkina Ekaterina, ; Mcgill University |
| patents.description.cc | US |
| patents.description.country | United States of America |
| patents.description.kind | A1 |
| dc.description.nature | published_or_final_version |
| dc.format.extent | 2114508 bytes |
| dc.format.extent | 1808 bytes |
| dc.format.mimetype | application/pdf |
| dc.format.mimetype | text/plain |
| patents.identifier.application | US 10/363768 |
| dc.identifier.citation | US Published patent application 20040038399. Washington, DC: US Patent and Trademark Office (USPTO), 2004 [How to Cite?] |
| patents.identifier.publication | US 20040038399 |
| dc.identifier.uri | http://hdl.handle.net/10722/47016 |
| dc.language | eng |
| patents.relation.family | AT 293688 (T) 2005-05-15 |
| patents.relation.family | AU 8944801 (A) 2002-03-22 |
| patents.relation.family | AU 2001289448 (B2) 2006-03-16 |
| patents.relation.family | CA 2419563 (A1) 2002-03-14 |
| patents.relation.family | DE 60110244 (T2) 2006-01-19 |
| patents.relation.family | EP 1315807 (A2) 2003-06-04 |
| patents.relation.family | JP 2004507272 (A) 2004-03-11 |
| patents.relation.family | US 2004038399 (A1) 2004-02-26 |
| patents.relation.family | US 8178348 (B2) 2012-05-15 |
| patents.relation.family | WO 0220773 (A2) 2002-03-14 |
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents |
| dc.title | Chimeric Antisense Oligonucleotides Of Arabinofuranose Analogue And Deoxyribose Nucleotides |
| dc.type | Patent |
| patents.type | Patent_published |