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Conference Paper: The Mitochondrial Calcium Uniporter participates in Ischemia/Reperfusion Injury and in Cardioprotection by Ischemic Preconditioning

TitleThe Mitochondrial Calcium Uniporter participates in Ischemia/Reperfusion Injury and in Cardioprotection by Ischemic Preconditioning
Authors
KeywordsHeart
mitochondrial calcium uniporter
ischemic preconditioning
Issue Date2004
PublisherIEEE.
Citation
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, San Francisco, CA, USA, 1-5 September 2004, v. 2, p. 3625-3627 How to Cite?
AbstractThe objective of the present study was to determine whether the mitochondrial calcium uniporter plays a role in cardioprotection by ischemic preconditioning (IPC). Isolated rat hearts were subjected to 30 min regional ischemia by ligation of the left anterior descending artery followed by 120 min reperfusion. We found that both IPC and inhibition of the mitochondrial calcium uniporter during reperfusion improved recovery of left ventricular developed pressure, maximal rise velocity and end-diastolic pressure, and reduced infarct size and lactate dehydrogenase release. These protective effects were attenuated by activating the mitochondrial calcium uniporter. We conclude that the mitochondrial calcium uniporter is involved in the cardioprotection of ischemic preconditioning.
Persistent Identifierhttp://hdl.handle.net/10722/46972
ISSN

 

DC FieldValueLanguage
dc.contributor.authorZhang, SZen_HK
dc.contributor.authorXia, Qen_HK
dc.contributor.authorCao, Cen_HK
dc.contributor.authorGao, Qen_HK
dc.contributor.authorBruce, ICen_HK
dc.date.accessioned2007-10-30T07:02:48Z-
dc.date.available2007-10-30T07:02:48Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, San Francisco, CA, USA, 1-5 September 2004, v. 2, p. 3625-3627en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/46972-
dc.description.abstractThe objective of the present study was to determine whether the mitochondrial calcium uniporter plays a role in cardioprotection by ischemic preconditioning (IPC). Isolated rat hearts were subjected to 30 min regional ischemia by ligation of the left anterior descending artery followed by 120 min reperfusion. We found that both IPC and inhibition of the mitochondrial calcium uniporter during reperfusion improved recovery of left ventricular developed pressure, maximal rise velocity and end-diastolic pressure, and reduced infarct size and lactate dehydrogenase release. These protective effects were attenuated by activating the mitochondrial calcium uniporter. We conclude that the mitochondrial calcium uniporter is involved in the cardioprotection of ischemic preconditioning.en_HK
dc.format.extent1045672 bytes-
dc.format.extent555997 bytes-
dc.format.extent3292 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIEEE.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_HK
dc.subjectHearten_HK
dc.subjectmitochondrial calcium uniporteren_HK
dc.subjectischemic preconditioningen_HK
dc.titleThe Mitochondrial Calcium Uniporter participates in Ischemia/Reperfusion Injury and in Cardioprotection by Ischemic Preconditioningen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=2&spage=3625&epage=3627&date=2004&atitle=The+Mitochondrial+Calcium+Uniporter+participates+in+Ischemia/Reperfusion+Injury+and+in+Cardioprotection+by+Ischemic+Preconditioningen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.hkuros98269-

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