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Conference Paper: Vasorelaxant effect of total flavones from Dendranthema morifolium on rat thoracic aorta

TitleVasorelaxant effect of total flavones from Dendranthema morifolium on rat thoracic aorta
Authors
KeywordsDendranthema morifolium
total flavones
aorta
beta-adrenoceptor
Issue Date2003
PublisherIEEE.
Citation
The 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, Cancun, Mexico, 17-21 September 2003, v. 1, p. 305-307 How to Cite?
AbstractTo investigate the vasorelaxant effect of total flavones from Dendranthema morifolium (Ramat.) Tzvel. cv. Hangju (FDM), tension was recorded from rat thoracic aortic rings. FDM completely relaxed, in a dose-dependent manner, the contractions induced by either phenylephrine (PE) or a high concentration of KCl (60 mM) in rings with intact endothelium. Mechanical removal of the endothelium did not significantly modify the vasorelaxant effect of FDM. In endothelium-denuded aortic rings depolarized by 60 mM KCl, FDM inhibited Ca/sup 2+/-induced contraction. FDM also reduced the transient contraction elicited by PE in Ca/sup 2+/-free medium, but had no effect on active phorbol ester-induced contraction. Pretreatment of endothelium-denuded aorta with propranolol, a beta-adrenoceptor antagonist, significantly attenuated the relaxant effect of FDM. These results indicate that FDM induces an endothelium-independent relaxation in rat aortic rings. The mechanisms may include the activation of beta-adrenergic receptors, reduction in Ca/sup 2+/ influx through the voltage-dependent and receptor-operated channels, and inhibition of intracellular Ca release in vascular smooth muscle cells.
Persistent Identifierhttp://hdl.handle.net/10722/46970
ISSN

 

DC FieldValueLanguage
dc.contributor.authorJin, HFen_HK
dc.contributor.authorShan, QXen_HK
dc.contributor.authorJiang, HDen_HK
dc.contributor.authorTu, Jen_HK
dc.contributor.authorBruce, ICen_HK
dc.contributor.authorXia, Qen_HK
dc.date.accessioned2007-10-30T07:02:44Z-
dc.date.available2007-10-30T07:02:44Z-
dc.date.issued2003en_HK
dc.identifier.citationThe 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, Cancun, Mexico, 17-21 September 2003, v. 1, p. 305-307en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/46970-
dc.description.abstractTo investigate the vasorelaxant effect of total flavones from Dendranthema morifolium (Ramat.) Tzvel. cv. Hangju (FDM), tension was recorded from rat thoracic aortic rings. FDM completely relaxed, in a dose-dependent manner, the contractions induced by either phenylephrine (PE) or a high concentration of KCl (60 mM) in rings with intact endothelium. Mechanical removal of the endothelium did not significantly modify the vasorelaxant effect of FDM. In endothelium-denuded aortic rings depolarized by 60 mM KCl, FDM inhibited Ca/sup 2+/-induced contraction. FDM also reduced the transient contraction elicited by PE in Ca/sup 2+/-free medium, but had no effect on active phorbol ester-induced contraction. Pretreatment of endothelium-denuded aorta with propranolol, a beta-adrenoceptor antagonist, significantly attenuated the relaxant effect of FDM. These results indicate that FDM induces an endothelium-independent relaxation in rat aortic rings. The mechanisms may include the activation of beta-adrenergic receptors, reduction in Ca/sup 2+/ influx through the voltage-dependent and receptor-operated channels, and inhibition of intracellular Ca release in vascular smooth muscle cells.en_HK
dc.format.extent310513 bytes-
dc.format.extent3292 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIEEE.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2003 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_HK
dc.subjectDendranthema morifoliumen_HK
dc.subjecttotal flavonesen_HK
dc.subjectaortaen_HK
dc.subjectbeta-adrenoceptoren_HK
dc.titleVasorelaxant effect of total flavones from Dendranthema morifolium on rat thoracic aortaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=1&spage=305&epage=307&date=2003&atitle=Vasorelaxant+effect+of+total+flavones+from+Dendranthema+morifolium+on+rat+thoracic+aortaen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1109/IEMBS.2003.1279621en_HK
dc.identifier.hkuros81475-

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