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Conference Paper: Alterations of coronary perfusion pressure and cardiac contraction during lipopolysaccharide challenge

TitleAlterations of coronary perfusion pressure and cardiac contraction during lipopolysaccharide challenge
Authors
KeywordsCoronary perfusion pressure
contraction
LPS
nitric oxide
endothelin
Issue Date2003
PublisherIEEE.
Citation
The 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, Cancun, Mexico, 17-21 September 2003, v. 1, p. 115-118 How to Cite?
AbstractIn the present study, we used the Langendorff technique to evaluate the involvement of endothelin-1 (ET-I) and nitric oxide (NO) in coronary vasoconstriction and myocardial depression in hearts isolated from lipopolysaccharide (LPS)-treated rats. Coronary perfusion pressure (CPP) increased markedly in hearts from LPS -treated rats. Pretreatment with BQ-123, an ET-1 type A receptor antagonist, significantly reduced the increase in CPP induced by LPS. LPS induced a marked decrease in left ventricular developed pressure, the product of left ventricular developed pressure and heart rate, as well as the maximal rate of rise/fall of left ventricular pressure. Pretreatment with BQ-123 partially reversed the LPS-induced cardiac depression. Administration of BQ-123 and AMG, an inhibitor of iNOS, prior to LPS challenge significantly blocked the negative inotropic effect. These results suggest that ET-1 augments the NO-mediated cardiac contractile depression induced by LPS and the accompanying increase in coronary resistance.
Persistent Identifierhttp://hdl.handle.net/10722/46969
ISSN

 

DC FieldValueLanguage
dc.contributor.authorTu, Jen_HK
dc.contributor.authorShan, QXen_HK
dc.contributor.authorJin, HFen_HK
dc.contributor.authorBruce, ICen_HK
dc.contributor.authorXia, Qen_HK
dc.date.accessioned2007-10-30T07:02:42Z-
dc.date.available2007-10-30T07:02:42Z-
dc.date.issued2003en_HK
dc.identifier.citationThe 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, Cancun, Mexico, 17-21 September 2003, v. 1, p. 115-118en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/46969-
dc.description.abstractIn the present study, we used the Langendorff technique to evaluate the involvement of endothelin-1 (ET-I) and nitric oxide (NO) in coronary vasoconstriction and myocardial depression in hearts isolated from lipopolysaccharide (LPS)-treated rats. Coronary perfusion pressure (CPP) increased markedly in hearts from LPS -treated rats. Pretreatment with BQ-123, an ET-1 type A receptor antagonist, significantly reduced the increase in CPP induced by LPS. LPS induced a marked decrease in left ventricular developed pressure, the product of left ventricular developed pressure and heart rate, as well as the maximal rate of rise/fall of left ventricular pressure. Pretreatment with BQ-123 partially reversed the LPS-induced cardiac depression. Administration of BQ-123 and AMG, an inhibitor of iNOS, prior to LPS challenge significantly blocked the negative inotropic effect. These results suggest that ET-1 augments the NO-mediated cardiac contractile depression induced by LPS and the accompanying increase in coronary resistance.en_HK
dc.format.extent309274 bytes-
dc.format.extent3292 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIEEE.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2003 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_HK
dc.subjectCoronary perfusion pressureen_HK
dc.subjectcontractionen_HK
dc.subjectLPSen_HK
dc.subjectnitric oxideen_HK
dc.subjectendothelinen_HK
dc.titleAlterations of coronary perfusion pressure and cardiac contraction during lipopolysaccharide challengeen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=1&spage=115&epage=118&date=2003&atitle=Alterations+of+coronary+perfusion+pressure+and+cardiac+contraction+during+lipopolysaccharide+challengeen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1109/IEMBS.2003.1279524en_HK
dc.identifier.hkuros81462-

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