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Conference Paper: Interleukin-2 Confers Cardioprotection by Inhibiting Mitochondrial Permeability Transition Pore

TitleInterleukin-2 Confers Cardioprotection by Inhibiting Mitochondrial Permeability Transition Pore
Authors
KeywordsInterleukin-2
heart
ischemia/reperfusion
mitochondria permeability transition pore
Issue Date2004
PublisherIEEE.
Citation
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, San Francisco, CA, USA, 1-5 September 2004, v. 2, p. 3618-3621 How to Cite?
AbstractIn the present study, we determined whether interleukin-2 (IL-2) confers cardioprotection by inhibiting mitochondria permeability transition pore (MPTP) opening. In isolated rat hearts subject to 30 min ischemia and 120 min reperfusion (IR), IL-2 (50 U/ml) decreased the infarct size and LDH release, effects blocked by a selective kappa-opioid receptor antagonist, Nor-BNI (5 microM) or an opener of MPTP, atractyloside (Atr, 20 microM). In isolated ventricular myocytes subjected to anoxia and reoxygenation (AR), which reduced both the amplitude of the electrically induced [Ca2+]i transient and diastolic [Ca2+]i, IL-2 attenuated the AR-induced alterations and their effects were abolished by Atr. In addition, IL-2 attenuated the reduction in calcein fluorescence in myocytes subject to AR and reduced calcium-induced swelling in mitochondria of rat hearts subjected to IR, which were similar to effect of inhibitor of MPTP. The observations indicated that IL-2 confers cardioprotection by inhibiting the MPTP opening.
Persistent Identifierhttp://hdl.handle.net/10722/46968
ISSN

 

DC FieldValueLanguage
dc.contributor.authorCao, CMen_HK
dc.contributor.authorChen, JZen_HK
dc.contributor.authorXia, Qen_HK
dc.contributor.authorZhang, SZen_HK
dc.contributor.authorLin, GHen_HK
dc.contributor.authorWong, TMen_HK
dc.date.accessioned2007-10-30T07:02:40Z-
dc.date.available2007-10-30T07:02:40Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings, San Francisco, CA, USA, 1-5 September 2004, v. 2, p. 3618-3621en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/46968-
dc.description.abstractIn the present study, we determined whether interleukin-2 (IL-2) confers cardioprotection by inhibiting mitochondria permeability transition pore (MPTP) opening. In isolated rat hearts subject to 30 min ischemia and 120 min reperfusion (IR), IL-2 (50 U/ml) decreased the infarct size and LDH release, effects blocked by a selective kappa-opioid receptor antagonist, Nor-BNI (5 microM) or an opener of MPTP, atractyloside (Atr, 20 microM). In isolated ventricular myocytes subjected to anoxia and reoxygenation (AR), which reduced both the amplitude of the electrically induced [Ca<sup>2+</sup>]i transient and diastolic [Ca<sup>2+</sup>]i, IL-2 attenuated the AR-induced alterations and their effects were abolished by Atr. In addition, IL-2 attenuated the reduction in calcein fluorescence in myocytes subject to AR and reduced calcium-induced swelling in mitochondria of rat hearts subjected to IR, which were similar to effect of inhibitor of MPTP. The observations indicated that IL-2 confers cardioprotection by inhibiting the MPTP opening.en_HK
dc.format.extent789075 bytes-
dc.format.extent555997 bytes-
dc.format.extent2073 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIEEE.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2004 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_HK
dc.subjectInterleukin-2en_HK
dc.subjecthearten_HK
dc.subjectischemia/reperfusionen_HK
dc.subjectmitochondria permeability transition poreen_HK
dc.titleInterleukin-2 Confers Cardioprotection by Inhibiting Mitochondrial Permeability Transition Poreen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=2&spage=3618&epage=3621&date=2004&atitle=Interleukin-2+Confers+Cardioprotection+by+Inhibiting+Mitochondrial+Permeability+Transition+Poreen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1109/IEMBS.2004.1404017en_HK
dc.identifier.pmid17271075en_HK

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