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Article: Epstein-Barr virus DNA in nasopharyngeal carcinomas from Chinese patients in Hong Kong

TitleEpstein-Barr virus DNA in nasopharyngeal carcinomas from Chinese patients in Hong Kong
Authors
Issue Date1992
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1992, v. 45 n. 5, p. 396-397 How to Cite?
AbstractAims: To investigate the presence of Epstein-Barr virus (EBV) in cases of nasopharyngeal carcinoma (NPC) in Chinese patients living in Hong Kong. Methods: Nasopharyngeal biopsy specimens, formalin fixed and paraffin wax embedded, from 24 patients, eight with undifferentiated nasopharyngeal carcinoma, eight with well differentiated squamous carcinoma, and eight showing normal tissue histology, were analysed for the presence of Epstein-Barr virus (EBV) DNA by slot-blot hybridisation on extracted unamplified DNA, and also after amplification of EBV specific sequences by the polymerase chain reaction (PCR). Results: DNA slot-blot analysis showed viral DNA in all the undifferentiated, five of the well differentiated tumours, and none of the normal biopsy specimens. PCR studies confirmed positivity in the eight undifferentiated tumours, but six of the well differentiated tumours and three of the normal biopsy specimens showed viral DNA by this method, illustrating its greater sensitivity. Conclusions: EBV genome is present in appreciable copy number in most cases of well differentiated NPC in Chinese patients in Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/46960
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDickens, Pen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorLoke, SLen_HK
dc.contributor.authorChan, CWen_HK
dc.contributor.authorLiu, YTen_HK
dc.date.accessioned2007-10-30T07:02:27Z-
dc.date.available2007-10-30T07:02:27Z-
dc.date.issued1992en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1992, v. 45 n. 5, p. 396-397en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/46960-
dc.description.abstractAims: To investigate the presence of Epstein-Barr virus (EBV) in cases of nasopharyngeal carcinoma (NPC) in Chinese patients living in Hong Kong. Methods: Nasopharyngeal biopsy specimens, formalin fixed and paraffin wax embedded, from 24 patients, eight with undifferentiated nasopharyngeal carcinoma, eight with well differentiated squamous carcinoma, and eight showing normal tissue histology, were analysed for the presence of Epstein-Barr virus (EBV) DNA by slot-blot hybridisation on extracted unamplified DNA, and also after amplification of EBV specific sequences by the polymerase chain reaction (PCR). Results: DNA slot-blot analysis showed viral DNA in all the undifferentiated, five of the well differentiated tumours, and none of the normal biopsy specimens. PCR studies confirmed positivity in the eight undifferentiated tumours, but six of the well differentiated tumours and three of the normal biopsy specimens showed viral DNA by this method, illustrating its greater sensitivity. Conclusions: EBV genome is present in appreciable copy number in most cases of well differentiated NPC in Chinese patients in Hong Kong.en_HK
dc.format.extent847587 bytes-
dc.format.extent2697 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subject.meshCarcinoma-microbiologyen_HK
dc.subject.meshCarcinoma,-Squamous-Cell-microbiologyen_HK
dc.subject.meshDNA,-Viral-analysisen_HK
dc.subject.meshHerpesvirus-4,-Human-isolation-and-purificationen_HK
dc.subject.meshNasopharyngeal-Neoplasms-microbiologyen_HK
dc.titleEpstein-Barr virus DNA in nasopharyngeal carcinomas from Chinese patients in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=45&issue=5&spage=396&epage=397&date=1992&atitle=Epstein-Barr+virus+DNA+in+nasopharyngeal+carcinomas+from+Chinese+patients+in+Hong+Kongen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid1317885-
dc.identifier.pmcidPMC495299-
dc.identifier.scopuseid_2-s2.0-0026509285en_HK
dc.identifier.volume45en_HK
dc.identifier.issue5en_HK
dc.identifier.spage396en_HK
dc.identifier.epage397en_HK
dc.identifier.isiWOS:A1992HR15700006-
dc.publisher.placeUnited Kingdomen_HK

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