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Article: Germ cell tumour as a diagnostic pitfall of metastatic carcinoma

TitleGerm cell tumour as a diagnostic pitfall of metastatic carcinoma
Authors
KeywordsCarcinoma of unknown primary
Cytology
Germ cell tumour
Placental-like alkaline phosphatase
Issue Date1996
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1996, v. 49 n. 3, p. 223-225 How to Cite?
AbstractAim - Testicular germ cell tumours may present as metastases in cervical lymph nodes, yet the primary tumours remain clinically occult. The aim of the study is to alert pathologists and clinicians to this uncommon but important presentation and highlight the clues and the diagnostic adjuncts to its correct diagnosis. Methods - The clinical, cytological, histological, and immunohistochemical features of two patients with germ cell tumour initially presenting as cervical lymphadenopathy were described and analysed. Results - Both patients were young adult males, who were found to have metastatic undifferentiated carcinoma on fine needle aspiration of the enlarged cervical lymph nodes. The tumour cells in both cases were positive for placental alkaline phosphatase (FLAP) and negative for epithelial membrane antigen (EMA). Conclusions - Clinicians and pathologists should be aware of the possibility of germ cell tumour when encountering a young adult male with metastatic poorly differentiated carcinoma. Positivity for FLAP and negativity for EMA are helpful adjuncts in arriving at the correct diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/46954
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLuk, ISCen_HK
dc.contributor.authorWong, MPen_HK
dc.date.accessioned2007-10-30T07:02:20Z-
dc.date.available2007-10-30T07:02:20Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1996, v. 49 n. 3, p. 223-225en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/46954-
dc.description.abstractAim - Testicular germ cell tumours may present as metastases in cervical lymph nodes, yet the primary tumours remain clinically occult. The aim of the study is to alert pathologists and clinicians to this uncommon but important presentation and highlight the clues and the diagnostic adjuncts to its correct diagnosis. Methods - The clinical, cytological, histological, and immunohistochemical features of two patients with germ cell tumour initially presenting as cervical lymphadenopathy were described and analysed. Results - Both patients were young adult males, who were found to have metastatic undifferentiated carcinoma on fine needle aspiration of the enlarged cervical lymph nodes. The tumour cells in both cases were positive for placental alkaline phosphatase (FLAP) and negative for epithelial membrane antigen (EMA). Conclusions - Clinicians and pathologists should be aware of the possibility of germ cell tumour when encountering a young adult male with metastatic poorly differentiated carcinoma. Positivity for FLAP and negativity for EMA are helpful adjuncts in arriving at the correct diagnosis.en_HK
dc.format.extent1468487 bytes-
dc.format.extent2834 bytes-
dc.format.extent1946 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subjectCarcinoma of unknown primaryen_HK
dc.subjectCytologyen_HK
dc.subjectGerm cell tumouren_HK
dc.subjectPlacental-like alkaline phosphataseen_HK
dc.subject.meshGerminoma-secondaryen_HK
dc.subject.meshLymphatic-Metastasis-pathologyen_HK
dc.subject.meshTesticular-Neoplasms-pathologyen_HK
dc.titleGerm cell tumour as a diagnostic pitfall of metastatic carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=49&issue=3&spage=223&epage=225&date=1996&atitle=Germ+cell+tumour+as+a+diagnostic+pitfall+of+metastatic+carcinomaen_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8675733-
dc.identifier.pmcidPMC500402-
dc.identifier.scopuseid_2-s2.0-0029898085en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029898085&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue3en_HK
dc.identifier.spage223en_HK
dc.identifier.epage225en_HK
dc.identifier.isiWOS:A1996UA49700008-
dc.publisher.placeUnited Kingdomen_HK

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