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Conference Paper: Melatonin reduced volume of cerebral infarct induced by photothrombosis in wild-type mice, not in Cyclooxygenase-1 gene knockout mice

TitleMelatonin reduced volume of cerebral infarct induced by photothrombosis in wild-type mice, not in Cyclooxygenase-1 gene knockout mice
Authors
KeywordsCerebral infarct
Cyclooxygenase-1 knockout
Melatonin
MR image
Issue Date2004
PublisherIEEE.
Citation
Annual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2004, v. 26 VII, p. 4748-4750 How to Cite?
AbstractCyclooxygenase (COX) is crucial in inflammation and plays important role in cerebral ischemia. Anti-inflammatory effects of melatonin have been verified in previous studies. In this study, cerebral blood flow (CBF) was monitored during operation, infarct volume (IFV) was determined with 5-triphenyltetrazolium chloride (TTC) staining and MR image, and neurological functions were evaluated with turn in an alley and fall pole test in both COX-1-gene knockout and wide-type mice with or without melatonin administration 3 days after photothrombosis. CBF reduction, IFV and neurological deficits were not significantly different in COX-1 wild-type and COX-1 knockout mice. Melatonin (15 mg/kg) intraperitoneal injection decreased the CBF reduction, IFV and the latency to turn in an alley in COX-1 wide-type mice, whereas the neuroprotective effect of melatonin was attenuated in COX-1 knockout mice. We concluded that melatonin reduced susceptibility to photothrombotic stroke. COX-1 gene knockout does not alter the susceptibility to cerebral ischemia caused by photothrombosis. COX-1 plays an important role in the pathway of the protection of melatonin.
Persistent Identifierhttp://hdl.handle.net/10722/45835
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorZou, LYen_HK
dc.contributor.authorLiu, SRen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorHuang, Len_HK
dc.contributor.authorYang, ESen_HK
dc.date.accessioned2007-10-30T06:36:35Z-
dc.date.available2007-10-30T06:36:35Z-
dc.date.issued2004en_HK
dc.identifier.citationAnnual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2004, v. 26 VII, p. 4748-4750en_HK
dc.identifier.issn0589-1019en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45835-
dc.description.abstractCyclooxygenase (COX) is crucial in inflammation and plays important role in cerebral ischemia. Anti-inflammatory effects of melatonin have been verified in previous studies. In this study, cerebral blood flow (CBF) was monitored during operation, infarct volume (IFV) was determined with 5-triphenyltetrazolium chloride (TTC) staining and MR image, and neurological functions were evaluated with turn in an alley and fall pole test in both COX-1-gene knockout and wide-type mice with or without melatonin administration 3 days after photothrombosis. CBF reduction, IFV and neurological deficits were not significantly different in COX-1 wild-type and COX-1 knockout mice. Melatonin (15 mg/kg) intraperitoneal injection decreased the CBF reduction, IFV and the latency to turn in an alley in COX-1 wide-type mice, whereas the neuroprotective effect of melatonin was attenuated in COX-1 knockout mice. We concluded that melatonin reduced susceptibility to photothrombotic stroke. COX-1 gene knockout does not alter the susceptibility to cerebral ischemia caused by photothrombosis. COX-1 plays an important role in the pathway of the protection of melatonin.en_HK
dc.format.extent975727 bytes-
dc.format.extent5169 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIEEE.en_HK
dc.relation.ispartofAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedingsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2005 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_HK
dc.subjectCerebral infarcten_HK
dc.subjectCyclooxygenase-1 knockouten_HK
dc.subjectMelatoninen_HK
dc.subjectMR imageen_HK
dc.titleMelatonin reduced volume of cerebral infarct induced by photothrombosis in wild-type mice, not in Cyclooxygenase-1 gene knockout miceen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=2&spage=4748&epage=4750&date=2005&atitle=Melatonin+reduced+volume+of+cerebral+infarct+induced+by+photothrombosis+in+wild-type+mice,+not+in+Cyclooxygenase-1+gene+knockout+miceen_HK
dc.identifier.emailYang, ES:esyang@hkueee.hku.hken_HK
dc.identifier.authorityYang, ES=rp00199en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1109/IEMBS.2004.1404314en_HK
dc.identifier.scopuseid_2-s2.0-11144314891en_HK
dc.identifier.hkuros112324-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-11144314891&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26 VIIen_HK
dc.identifier.spage4748en_HK
dc.identifier.epage4750en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZou, LY=23391539300en_HK
dc.identifier.scopusauthoridLiu, SR=14052125200en_HK
dc.identifier.scopusauthoridLi, G=7407054189en_HK
dc.identifier.scopusauthoridHuang, L=36925330700en_HK
dc.identifier.scopusauthoridYang, ES=7202021229en_HK

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