File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: MRI and image quantitation for drug assessment - Growth effects of anabolic steroids and precursors

TitleMRI and image quantitation for drug assessment - Growth effects of anabolic steroids and precursors
Authors
KeywordsMedical sciences
Computer applications
Issue Date2005
PublisherIEEE.
Citation
Annual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2005, v. 7 VOLS, p. 7044-7047 How to Cite?
AbstractMRI and image quantitation play an expanding role in modern drug research, because MRI offers high resolution and non-invasive ability, and provides excellent soft tissue contrast. Moreover, with development of effective image segmentation and analysis methods, in-vivo and serial tissue growth measurements could be assessed. In the study, MR image acquisition and analysis protocol were established and validated for investigating the effects of anabolic steroids and precursors on muscle growth and body composition in a guinea pig model. Semi-automatic and interactive segmentation methods were developed to accurately label the tissue of interest for tissue volume estimation. In addition, a longitudinal tissue area outlining procedure was proposed for study of tissue geometric features in relation to tissue growth. Finally, a fully automatic data retrieval and analysis scheme was implemented to facilitate the overall huge amount of image quantitation, statistical analysis, as well as study group comparisons. As a result, highly significant differences in muscle and organ growth were detected between intact and castrated guinea pigs using the selected anabolic steroids, indicating the viability of employing such protocol to assess other anabolic steroids. Furthermore, the anabolic potential of selected steroid precursors and their effects on muscle growth, in comparison with that in respective positive control groups of castrated guinea pigs, were evaluated with the proposed protocol. © 2005 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/45725
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Hen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorVasselli, JRen_HK
dc.date.accessioned2007-10-30T06:33:47Z-
dc.date.available2007-10-30T06:33:47Z-
dc.date.issued2005en_HK
dc.identifier.citationAnnual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2005, v. 7 VOLS, p. 7044-7047en_HK
dc.identifier.issn0589-1019en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45725-
dc.description.abstractMRI and image quantitation play an expanding role in modern drug research, because MRI offers high resolution and non-invasive ability, and provides excellent soft tissue contrast. Moreover, with development of effective image segmentation and analysis methods, in-vivo and serial tissue growth measurements could be assessed. In the study, MR image acquisition and analysis protocol were established and validated for investigating the effects of anabolic steroids and precursors on muscle growth and body composition in a guinea pig model. Semi-automatic and interactive segmentation methods were developed to accurately label the tissue of interest for tissue volume estimation. In addition, a longitudinal tissue area outlining procedure was proposed for study of tissue geometric features in relation to tissue growth. Finally, a fully automatic data retrieval and analysis scheme was implemented to facilitate the overall huge amount of image quantitation, statistical analysis, as well as study group comparisons. As a result, highly significant differences in muscle and organ growth were detected between intact and castrated guinea pigs using the selected anabolic steroids, indicating the viability of employing such protocol to assess other anabolic steroids. Furthermore, the anabolic potential of selected steroid precursors and their effects on muscle growth, in comparison with that in respective positive control groups of castrated guinea pigs, were evaluated with the proposed protocol. © 2005 IEEE.en_HK
dc.format.extent355341 bytes-
dc.format.extent2851 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIEEE.en_HK
dc.relation.ispartofAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedingsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2005 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.en_HK
dc.subjectMedical sciencesen_HK
dc.subjectComputer applicationsen_HK
dc.titleMRI and image quantitation for drug assessment - Growth effects of anabolic steroids and precursorsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=7044&epage=7047&date=2005&atitle=MRI+and+Image+Quantitation+for+Drug+Assessment+-+Growth+Effects+of+Anabolic+Steroids+and+Precursorsen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1109/IEMBS.2005.1616128en_HK
dc.identifier.scopuseid_2-s2.0-33846895226en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846895226&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7 VOLSen_HK
dc.identifier.spage7044en_HK
dc.identifier.epage7047en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, H=36827331000en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridVasselli, JR=7003912429en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats