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Article: Mouse models for human diseases

TitleMouse models for human diseases
Authors
KeywordsDisease models, animal
Cataract
Diabetic neuropahies
Hyperglycemia
Issue Date1997
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 1997, v. 3 n. 2, p. 201-209 How to Cite?
AbstractMice are increasingly being used as models for the study of various human diseases. This is primarily because among mammalian modals, they are most amenable to genetic manipulations. As we attempt to understand the molecular mechanism of diseases, it is imperative that the genes involved in the disease process be identified. One approach is to study mouse mutants with symptoms analogous to human diseases, and try to identify the genes responsible. Another approach is to manipulate the expression of genes suspected to be involved and see how they affect the disease development. This review briefly discusses the concept of manipulating gene expression by transgenic and gene knockout technology and illustrates this with how these technique are used to study the mechanism of diabetic complications.
Persistent Identifierhttp://hdl.handle.net/10722/45523
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChung, SKen_HK
dc.contributor.authorLee, AYWen_HK
dc.contributor.authorChung, SSMen_HK
dc.date.accessioned2007-10-30T06:28:19Z-
dc.date.available2007-10-30T06:28:19Z-
dc.date.issued1997en_HK
dc.identifier.citationHong Kong Medical Journal, 1997, v. 3 n. 2, p. 201-209en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45523-
dc.description.abstractMice are increasingly being used as models for the study of various human diseases. This is primarily because among mammalian modals, they are most amenable to genetic manipulations. As we attempt to understand the molecular mechanism of diseases, it is imperative that the genes involved in the disease process be identified. One approach is to study mouse mutants with symptoms analogous to human diseases, and try to identify the genes responsible. Another approach is to manipulate the expression of genes suspected to be involved and see how they affect the disease development. This review briefly discusses the concept of manipulating gene expression by transgenic and gene knockout technology and illustrates this with how these technique are used to study the mechanism of diabetic complications.en_HK
dc.format.extent605310 bytes-
dc.format.extent667084 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hken_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectDisease models, animalen_HK
dc.subjectCataracten_HK
dc.subjectDiabetic neuropahiesen_HK
dc.subjectHyperglycemiaen_HK
dc.titleMouse models for human diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=3&issue=2&spage=201&epage=209&date=1997&atitle=Mouse+models+for+human+diseasesen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11850572en_HK
dc.identifier.hkuros26429-

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