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Article: Longer term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS)

TitleLonger term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS)
Authors
Issue Date2006
PublisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/
Citation
Thorax, 2006, v. 61 n. 3, p. 240-246 How to Cite?
Abstract
Background: A study was undertaken to investigate the aerobic capacity and pulmonary function of children 6 and 15 months after the diagnosis of severe acute respiratory syndrome (SARS). Methods: Thirty four patients of mean age 14.7 years completed both pulmonary function and maximal aerobic capacity tests at 6 months. All had normal clinical examination and were asymptomatic. Their exercise responses were compared with a group of healthy controls. Complete data were collected on 27 of the original 34 cases at 15 months. Results: Compared with normal controls, the patient group had significantly lower absolute and mass related peak oxygen consumption (peak V̇O 2 (p<0.01)), higher ventilatory equivalent for oxygen (p<0.01), lower oxygen pulse (p<0.01), and a lower oxygen uptake efficiency slope (p<0.01) at 6 months. This impairment was unexpected and out of proportion with the degree of lung function abnormality. Residual high resolution computed tomography of thorax (HRCT) abnormalities were present in 14 patients. Those with abnormal HRCT findings had significantly lower mass related peak V̇O 2 than subjects with normal radiology (p<0.01). Absolute and mass related peak V̇O 2 in the patient group remained impaired at 15 months despite normalisation of lung function in all patients. Conclusions: The mechanism for the reduced aerobic capacity in children following SARS is not fully understood, but it is probably a consequence of impaired perfusion to the lungs at peak exercise and deconditioning.
Persistent Identifierhttp://hdl.handle.net/10722/45520
ISSN
2013 Impact Factor: 8.562
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. Sports Institute
  2. The University of Hong Kong
  3. Princess Margaret Hospital Hong Kong
  4. Queen Elizabeth Hospital Hong Kong
  5. Prince of Wales Hospital Hong Kong
  6. Pamela Youde Nethersole Eastern Hospital
  7. United Christian Hospital Hong Kong
  8. Chinese University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorYu, CCWen_HK
dc.contributor.authorLi, AMen_HK
dc.contributor.authorSo, RCHen_HK
dc.contributor.authorMcManus, Aen_HK
dc.contributor.authorNg, PCen_HK
dc.contributor.authorChu, Wen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheng, Fen_HK
dc.contributor.authorChiu, WKen_HK
dc.contributor.authorLeung, CWen_HK
dc.contributor.authorYau, YSen_HK
dc.contributor.authorMo, KWen_HK
dc.contributor.authorWong, EMCen_HK
dc.contributor.authorCheung, AYKen_HK
dc.contributor.authorLeung, TFen_HK
dc.contributor.authorSung, RYTen_HK
dc.contributor.authorFok, TFen_HK
dc.date.accessioned2007-10-30T06:28:09Z-
dc.date.available2007-10-30T06:28:09Z-
dc.date.issued2006en_HK
dc.identifier.citationThorax, 2006, v. 61 n. 3, p. 240-246en_HK
dc.identifier.issn0040-6376en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45520-
dc.description.abstractBackground: A study was undertaken to investigate the aerobic capacity and pulmonary function of children 6 and 15 months after the diagnosis of severe acute respiratory syndrome (SARS). Methods: Thirty four patients of mean age 14.7 years completed both pulmonary function and maximal aerobic capacity tests at 6 months. All had normal clinical examination and were asymptomatic. Their exercise responses were compared with a group of healthy controls. Complete data were collected on 27 of the original 34 cases at 15 months. Results: Compared with normal controls, the patient group had significantly lower absolute and mass related peak oxygen consumption (peak V̇O 2 (p<0.01)), higher ventilatory equivalent for oxygen (p<0.01), lower oxygen pulse (p<0.01), and a lower oxygen uptake efficiency slope (p<0.01) at 6 months. This impairment was unexpected and out of proportion with the degree of lung function abnormality. Residual high resolution computed tomography of thorax (HRCT) abnormalities were present in 14 patients. Those with abnormal HRCT findings had significantly lower mass related peak V̇O 2 than subjects with normal radiology (p<0.01). Absolute and mass related peak V̇O 2 in the patient group remained impaired at 15 months despite normalisation of lung function in all patients. Conclusions: The mechanism for the reduced aerobic capacity in children following SARS is not fully understood, but it is probably a consequence of impaired perfusion to the lungs at peak exercise and deconditioning.en_HK
dc.format.extent224494 bytes-
dc.format.extent1788 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/en_HK
dc.relation.ispartofThoraxen_HK
dc.rightsThorax. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshExercise Tolerance - physiologyen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - physiopathologyen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshOxygen Consumption - physiologyen_HK
dc.subject.meshRespiratory Function Testsen_HK
dc.titleLonger term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS)en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0040-6376&volume=61&issue=3&spage=240&epage=246&date=2006&atitle=Longer+term+follow+up+of+aerobic+capacity+in+children+affected+by+severe+acute+respiratory+syndrome+(SARS)en_HK
dc.identifier.emailYu, CCW: yucw@hkucc.hku.hken_HK
dc.identifier.emailMcManus, A: alimac@hku.hken_HK
dc.identifier.authorityYu, CCW=rp00982en_HK
dc.identifier.authorityMcManus, A=rp00936en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/thx.2005.046854en_HK
dc.identifier.pmid16449271en_HK
dc.identifier.pmcidPMC2080724-
dc.identifier.scopuseid_2-s2.0-33645056422en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645056422&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue3en_HK
dc.identifier.spage240en_HK
dc.identifier.epage246en_HK
dc.identifier.isiWOS:000235776700013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYu, CCW=35235958400en_HK
dc.identifier.scopusauthoridLi, AM=34570729600en_HK
dc.identifier.scopusauthoridSo, RCH=7102099493en_HK
dc.identifier.scopusauthoridMcManus, A=7004635919en_HK
dc.identifier.scopusauthoridNg, PC=7201376998en_HK
dc.identifier.scopusauthoridChu, W=7402227871en_HK
dc.identifier.scopusauthoridChan, D=14019025300en_HK
dc.identifier.scopusauthoridCheng, F=7202811097en_HK
dc.identifier.scopusauthoridChiu, WK=7201503495en_HK
dc.identifier.scopusauthoridLeung, CW=7402612619en_HK
dc.identifier.scopusauthoridYau, YS=36960830900en_HK
dc.identifier.scopusauthoridMo, KW=12787180700en_HK
dc.identifier.scopusauthoridWong, EMC=13409091100en_HK
dc.identifier.scopusauthoridCheung, AYK=36658739100en_HK
dc.identifier.scopusauthoridLeung, TF=7202110942en_HK
dc.identifier.scopusauthoridSung, RYT=7101684314en_HK
dc.identifier.scopusauthoridFok, TF=7006455238en_HK

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