Article: Longer term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS)

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TitleLonger term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS)
AuthorsYu, CCW2 8
Li, AM5 8
So, RCH1
McManus, A2
Ng, PC8
Chu, W8
Chan, D8
Cheng, F8
Chiu, WK7
Leung, CW3
Yau, YS4
Mo, KW6
Wong, EMC5
Cheung, AYK5
Leung, TF8
Sung, RYT8
Fok, TF8
Issue Date2006
PublisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/
CitationThorax, 2006, v. 61 n. 3, p. 240-246 [How to Cite?]
DOI: http://dx.doi.org/10.1136/thx.2005.046854
AbstractBackground: A study was undertaken to investigate the aerobic capacity and pulmonary function of children 6 and 15 months after the diagnosis of severe acute respiratory syndrome (SARS). Methods: Thirty four patients of mean age 14.7 years completed both pulmonary function and maximal aerobic capacity tests at 6 months. All had normal clinical examination and were asymptomatic. Their exercise responses were compared with a group of healthy controls. Complete data were collected on 27 of the original 34 cases at 15 months. Results: Compared with normal controls, the patient group had significantly lower absolute and mass related peak oxygen consumption (peak V̇O 2 (p<0.01)), higher ventilatory equivalent for oxygen (p<0.01), lower oxygen pulse (p<0.01), and a lower oxygen uptake efficiency slope (p<0.01) at 6 months. This impairment was unexpected and out of proportion with the degree of lung function abnormality. Residual high resolution computed tomography of thorax (HRCT) abnormalities were present in 14 patients. Those with abnormal HRCT findings had significantly lower mass related peak V̇O 2 than subjects with normal radiology (p<0.01). Absolute and mass related peak V̇O 2 in the patient group remained impaired at 15 months despite normalisation of lung function in all patients. Conclusions: The mechanism for the reduced aerobic capacity in children following SARS is not fully understood, but it is probably a consequence of impaired perfusion to the lungs at peak exercise and deconditioning.
ISSN0040-6376
2011 Impact Factor: 6.84
2011 SCImago Journal Rankings: 0.429
DOIhttp://dx.doi.org/10.1136/thx.2005.046854
ISI Accession Number IDWOS:000235776700013
PubMed Central IDPMC2080724
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYu, CCW
dc.contributor.authorLi, AM
dc.contributor.authorSo, RCH
dc.contributor.authorMcManus, A
dc.contributor.authorNg, PC
dc.contributor.authorChu, W
dc.contributor.authorChan, D
dc.contributor.authorCheng, F
dc.contributor.authorChiu, WK
dc.contributor.authorLeung, CW
dc.contributor.authorYau, YS
dc.contributor.authorMo, KW
dc.contributor.authorWong, EMC
dc.contributor.authorCheung, AYK
dc.contributor.authorLeung, TF
dc.contributor.authorSung, RYT
dc.contributor.authorFok, TF
dc.date.accessioned2007-10-30T06:28:09Z
dc.date.available2007-10-30T06:28:09Z
dc.date.issued2006
dc.description.abstractBackground: A study was undertaken to investigate the aerobic capacity and pulmonary function of children 6 and 15 months after the diagnosis of severe acute respiratory syndrome (SARS). Methods: Thirty four patients of mean age 14.7 years completed both pulmonary function and maximal aerobic capacity tests at 6 months. All had normal clinical examination and were asymptomatic. Their exercise responses were compared with a group of healthy controls. Complete data were collected on 27 of the original 34 cases at 15 months. Results: Compared with normal controls, the patient group had significantly lower absolute and mass related peak oxygen consumption (peak V̇O 2 (p<0.01)), higher ventilatory equivalent for oxygen (p<0.01), lower oxygen pulse (p<0.01), and a lower oxygen uptake efficiency slope (p<0.01) at 6 months. This impairment was unexpected and out of proportion with the degree of lung function abnormality. Residual high resolution computed tomography of thorax (HRCT) abnormalities were present in 14 patients. Those with abnormal HRCT findings had significantly lower mass related peak V̇O 2 than subjects with normal radiology (p<0.01). Absolute and mass related peak V̇O 2 in the patient group remained impaired at 15 months despite normalisation of lung function in all patients. Conclusions: The mechanism for the reduced aerobic capacity in children following SARS is not fully understood, but it is probably a consequence of impaired perfusion to the lungs at peak exercise and deconditioning.
dc.description.naturepublished_or_final_version
dc.format.extent224494 bytes
dc.format.extent1788 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.identifier.citationThorax, 2006, v. 61 n. 3, p. 240-246 [How to Cite?]
DOI: http://dx.doi.org/10.1136/thx.2005.046854
dc.identifier.doihttp://dx.doi.org/10.1136/thx.2005.046854
dc.identifier.epage246
dc.identifier.isiWOS:000235776700013
dc.identifier.issn0040-6376
2011 Impact Factor: 6.84
2011 SCImago Journal Rankings: 0.429
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmcidPMC2080724
dc.identifier.pmid16449271
dc.identifier.scopuseid_2-s2.0-33645056422
dc.identifier.spage240
dc.identifier.urihttp://hdl.handle.net/10722/45520
dc.identifier.volume61
dc.languageeng
dc.publisherB M J Publishing Group. The Journal's web site is located at http://thorax.bmjjournals.com/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofThorax
dc.relation.referencesReferences in Scopus
dc.rightsThorax. Copyright © B M J Publishing Group.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshExercise Tolerance - physiology
dc.subject.meshSevere Acute Respiratory Syndrome - physiopathology
dc.subject.meshAnalysis of Variance
dc.subject.meshOxygen Consumption - physiology
dc.subject.meshRespiratory Function Tests
dc.titleLonger term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS)
dc.typeArticle
Author Affiliations
  1. Sports Institute
  2. The University of Hong Kong
  3. Princess Margaret Hospital Hong Kong
  4. Queen Elizabeth Hospital Hong Kong
  5. Prince of Wales Hospital Hong Kong
  6. Pamela Youde Nethersole Eastern Hospital
  7. United Christian Hospital Hong Kong
  8. Chinese University of Hong Kong