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Article: Changes in host muscles induced by excretory/secretory products of larval Trichinella spiralis and Trichinella pseudospiralis

TitleChanges in host muscles induced by excretory/secretory products of larval Trichinella spiralis and Trichinella pseudospiralis
Authors
Issue Date1994
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PAR
Citation
Parasitology (Cambridge), 1994, v. 108 n. Pt 2, p. 195-205 How to Cite?
AbstractExcretory/secretory (ES) products obtained by in vitro culture of infective-stage larvae of Trichinella spiralis and T. pseudospiralis were injected intramuscularly at various intervals into mice. Mini-osmotic pumps containing T. spiralis ES products were also implanted subcutaneously and intraperitoneally into rats. The introduction of ES materials into muscles elicited extensive lesions which included dissolution of myofibres, mobilization of mononuclear and polymorphonuclear leucocytes, angiogenesis, hypertrophy of myonuclei, myotube formation, mitosis, muscle bundles becoming rounded and separated from each other, disappearance of Z, I and A bands of sarcomeres, increase in endoplasmic reticulum and Golgi complexes, decrease in glycogen and relocation of mitochondria. These are considered as degenerative/regenerative changes of muscles to injury. Immunodominant epitopes of specific 45-53 kDa glycoproteins in ES antigens of T. spiralis could not be detected in hypertrophic nuclei of injected muscles by using polyclonal and monoclonal antibodies and immunocytochemical methods. ES products of T. spiralis failed to stimulate unsensitized lymphocytes in the lymphocyte transformation test. Infective-stage larvae of T. spiralis released from muscles were found capable of forming nurse cells after injection subcutaneously into rats. It is postulated that the invasion of muscles by trichinellids elicits two independent events, i.e. a general degenerative/regenerative response of muscles and a specific change in genomic expression of myonuclei. The two events are probably mediated by different effector molecules.
Persistent Identifierhttp://hdl.handle.net/10722/45433
ISSN
2015 Impact Factor: 3.031
2015 SCImago Journal Rankings: 1.327
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKo, RCCen_HK
dc.contributor.authorFan, Len_HK
dc.contributor.authorLee, DLen_HK
dc.contributor.authorCompton, Hen_HK
dc.date.accessioned2007-10-30T06:25:26Z-
dc.date.available2007-10-30T06:25:26Z-
dc.date.issued1994en_HK
dc.identifier.citationParasitology (Cambridge), 1994, v. 108 n. Pt 2, p. 195-205en_HK
dc.identifier.issn0031-1820en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45433-
dc.description.abstractExcretory/secretory (ES) products obtained by in vitro culture of infective-stage larvae of Trichinella spiralis and T. pseudospiralis were injected intramuscularly at various intervals into mice. Mini-osmotic pumps containing T. spiralis ES products were also implanted subcutaneously and intraperitoneally into rats. The introduction of ES materials into muscles elicited extensive lesions which included dissolution of myofibres, mobilization of mononuclear and polymorphonuclear leucocytes, angiogenesis, hypertrophy of myonuclei, myotube formation, mitosis, muscle bundles becoming rounded and separated from each other, disappearance of Z, I and A bands of sarcomeres, increase in endoplasmic reticulum and Golgi complexes, decrease in glycogen and relocation of mitochondria. These are considered as degenerative/regenerative changes of muscles to injury. Immunodominant epitopes of specific 45-53 kDa glycoproteins in ES antigens of T. spiralis could not be detected in hypertrophic nuclei of injected muscles by using polyclonal and monoclonal antibodies and immunocytochemical methods. ES products of T. spiralis failed to stimulate unsensitized lymphocytes in the lymphocyte transformation test. Infective-stage larvae of T. spiralis released from muscles were found capable of forming nurse cells after injection subcutaneously into rats. It is postulated that the invasion of muscles by trichinellids elicits two independent events, i.e. a general degenerative/regenerative response of muscles and a specific change in genomic expression of myonuclei. The two events are probably mediated by different effector molecules.en_HK
dc.format.extent7368178 bytes-
dc.format.extent3069 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PARen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsParasitology (Cambridge). Copyright © Cambridge University Press.en_HK
dc.subject.meshHelminth-Proteins-pharmacologyen_HK
dc.subject.meshMuscles-parasitologyen_HK
dc.subject.meshTrichinella-physiologyen_HK
dc.subject.meshTrichinella-spiralis-physiologyen_HK
dc.titleChanges in host muscles induced by excretory/secretory products of larval Trichinella spiralis and Trichinella pseudospiralisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0031-1820&volume=108&issue=Pt 2&spage=195&epage=205&date=1994&atitle=Changes+in+host+muscles+induced+by+excretory/secretory+products+of+larval+Trichinella+spiralis+and+Trichinella+pseudospiralisen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8159465en_HK
dc.identifier.isiWOS:A1994MX71500009-

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