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Article: Transient changes of transforming growth factor-β expression in the small intestine of the pig in association with weaning

TitleTransient changes of transforming growth factor-β expression in the small intestine of the pig in association with weaning
Authors
KeywordsIntestine
Transforming growth factor-β
Weaning pig
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJN
Citation
British Journal Of Nutrition, 2005, v. 93 n. 1, p. 37-45 How to Cite?
AbstractIt is well known that early weaning causes marked changes in intestinal structure and function, and transforming growth factor-β (TGF-β) is believed to play an important regulatory role in post-weaning adaptation of the small intestine. The present study examined the distribution and expression intensity of TGF-β in the small intestinal mucosa of pre- and post-weaning pigs using a specific immunostaining technique and Western blot analysis. The level of TGF-β in the intestinal mucosa, as estimated by Western blot analysis, did not change significantly during weaning. However, when examined by the immunostaining technique, TGF-β1 (one of the TGF-β isoforms dominantly expressed in the tissue) at the intestinal villus epithelium, particularly at the apical membrane of the epithelium, decreased significantly 4 d after weaning, while the staining intensity increased significantly at the intestinal crypts compared with that in pre-weaning pigs. These changes were transient, with the immunostaining intensity for TGF-β1 at the intestinal villi and the crypts returning to the pre-weaning level by 8d post-weaning. The transient decrease in TGF-β1 level at the intestinal villus epithelium was associated with obvious intestinal villus atrophy and marked reduction of mucosal digestive enzyme activities. Furthermore, the number of leucocytes staining positively for TGF-β1 increased significantly in the pig intestinal lamina propria 4 d after weaning. These findings strongly suggest that TGF-β plays an important role in the post-weaning adaptation process in the intestine of the pig. © The Authors 2005.
Persistent Identifierhttp://hdl.handle.net/10722/45432
ISSN
2015 Impact Factor: 3.311
2015 SCImago Journal Rankings: 1.587
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMei, Jen_HK
dc.contributor.authorXu, RJen_HK
dc.date.accessioned2007-10-30T06:25:24Z-
dc.date.available2007-10-30T06:25:24Z-
dc.date.issued2005en_HK
dc.identifier.citationBritish Journal Of Nutrition, 2005, v. 93 n. 1, p. 37-45en_HK
dc.identifier.issn0007-1145en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45432-
dc.description.abstractIt is well known that early weaning causes marked changes in intestinal structure and function, and transforming growth factor-β (TGF-β) is believed to play an important regulatory role in post-weaning adaptation of the small intestine. The present study examined the distribution and expression intensity of TGF-β in the small intestinal mucosa of pre- and post-weaning pigs using a specific immunostaining technique and Western blot analysis. The level of TGF-β in the intestinal mucosa, as estimated by Western blot analysis, did not change significantly during weaning. However, when examined by the immunostaining technique, TGF-β1 (one of the TGF-β isoforms dominantly expressed in the tissue) at the intestinal villus epithelium, particularly at the apical membrane of the epithelium, decreased significantly 4 d after weaning, while the staining intensity increased significantly at the intestinal crypts compared with that in pre-weaning pigs. These changes were transient, with the immunostaining intensity for TGF-β1 at the intestinal villi and the crypts returning to the pre-weaning level by 8d post-weaning. The transient decrease in TGF-β1 level at the intestinal villus epithelium was associated with obvious intestinal villus atrophy and marked reduction of mucosal digestive enzyme activities. Furthermore, the number of leucocytes staining positively for TGF-β1 increased significantly in the pig intestinal lamina propria 4 d after weaning. These findings strongly suggest that TGF-β plays an important role in the post-weaning adaptation process in the intestine of the pig. © The Authors 2005.en_HK
dc.format.extent553157 bytes-
dc.format.extent2210 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJNen_HK
dc.relation.ispartofBritish Journal of Nutritionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe British Journal of Nutrition. Copyright © Cambridge University Press.en_HK
dc.subjectIntestineen_HK
dc.subjectTransforming growth factor-βen_HK
dc.subjectWeaning pigen_HK
dc.subject.meshIntestine,-Small-metabolismen_HK
dc.subject.meshSwine-metabolismen_HK
dc.subject.meshTransforming-Growth-Factor-beta-metabolismen_HK
dc.subject.meshWeaning-en_HK
dc.titleTransient changes of transforming growth factor-β expression in the small intestine of the pig in association with weaningen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1145&volume=93&issue=1&spage=37&epage=45&date=2005&atitle=Transient+changes+of+transforming+growth+factor-beta+expression+in+the+small+intestine+of+the+pig+in+association+with+weaningen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1079/BJN20041302en_HK
dc.identifier.pmid15705223-
dc.identifier.scopuseid_2-s2.0-14144254193en_HK
dc.identifier.hkuros102507-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14144254193&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue1en_HK
dc.identifier.spage37en_HK
dc.identifier.epage45en_HK
dc.identifier.isiWOS:000226919600007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMei, J=36857285200en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK
dc.identifier.citeulike92542-

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