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Article: Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines

TitleReduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines
Authors
KeywordsAdiposity
Bitter melon
Catecholamines
Triacylglycerol
Issue Date2005
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJN
Citation
British Journal Of Nutrition, 2005, v. 93 n. 5, p. 747-754 How to Cite?
AbstractSlower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7.5 g/kg or 0.75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P<0.05) and steatosis score (P<0.05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P<0.05). In the third experiment, BM(7.5 and 15 g/kg) and 1.5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P<0.05) muscle, but a dose-response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose. © The Authors 2005.
Persistent Identifierhttp://hdl.handle.net/10722/45430
ISSN
2015 Impact Factor: 3.311
2015 SCImago Journal Rankings: 1.587
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Qen_HK
dc.contributor.authorLi, ETSen_HK
dc.date.accessioned2007-10-30T06:25:20Z-
dc.date.available2007-10-30T06:25:20Z-
dc.date.issued2005en_HK
dc.identifier.citationBritish Journal Of Nutrition, 2005, v. 93 n. 5, p. 747-754en_HK
dc.identifier.issn0007-1145en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45430-
dc.description.abstractSlower weight gain and less visceral fat had been observed when rats fed a high-fat diet were supplemented with freeze-dried bitter melon (BM) juice; the metabolic consequences and possible mechanism(s) were further explored in the present study. In a 4-week experiment, rats were fed a low-fat (70 g/kg) or a high-fat (300 g/kg) diet with or without BM (7.5 g/kg or 0.75%). BM-supplemented rats had lower energy efficiency, visceral fat mass, plasma glucose and hepatic triacylglycerol, but higher serum free fatty acids and plasma catecholamines. In the second experiment, 7-week BM supplementation in high-fat diet rats led to a lowering of hepatic triacylglycerol (P<0.05) and steatosis score (P<0.05) similar to those in rats fed a low-fat diet. BM supplementation did not affect serum and hepatic cholesterol. However, plasma epinephrine and serum free fatty acid concentrations were increased (P<0.05). In the third experiment, BM(7.5 and 15 g/kg) and 1.5 % BM lowered triacylglycerol concentration in red gastrocnemius and tibialis anterior (P<0.05) muscle, but a dose-response effect was not observed. These data suggest that chronic BM feeding leads to a general decrease in tissue fat accumulation and that such an effect is mediated in part by enhanced sympathetic activity and lipolysis. BM or its bioactive ingredient(s) could be used as a dietary adjunct in the control of body weight and blood glucose. © The Authors 2005.en_HK
dc.format.extent435414 bytes-
dc.format.extent1845 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=BJNen_HK
dc.relation.ispartofBritish Journal of Nutritionen_HK
dc.rightsThe British Journal of Nutrition. Copyright © Cambridge University Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAdiposityen_HK
dc.subjectBitter melonen_HK
dc.subjectCatecholaminesen_HK
dc.subjectTriacylglycerolen_HK
dc.subject.meshCatecholamines - blooden_HK
dc.subject.meshCucurbitaceaeen_HK
dc.subject.meshFatty Liver - metabolism - pathologyen_HK
dc.subject.meshLiver - chemistry - pathologyen_HK
dc.subject.meshObesity - metabolism - pathologyen_HK
dc.titleReduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholaminesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1145&volume=93&issue=5&spage=747&epage=754&date=2005&atitle=Reduced+adiposity+in+bitter+melon+(Momordica+charantia)+fed+rats+is+associated+with+lower+tissue+triglyceride+and+higher+plasma+catecholaminesen_HK
dc.identifier.emailLi, ETS: etsli@hku.hken_HK
dc.identifier.authorityLi, ETS=rp00737en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1079/BJN20051388en_HK
dc.identifier.pmid15975176en_HK
dc.identifier.scopuseid_2-s2.0-24344453383en_HK
dc.identifier.hkuros101947-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24344453383&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue5en_HK
dc.identifier.spage747en_HK
dc.identifier.epage754en_HK
dc.identifier.isiWOS:000230083400023-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChen, Q=55209782600en_HK
dc.identifier.scopusauthoridLi, ETS=14018169600en_HK
dc.identifier.citeulike231137-

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