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Article: Effects of a herbal compound containing bupleurum on human lymphocytes

TitleEffects of a herbal compound containing bupleurum on human lymphocytes
含柴胡的草藥對人類淋巴細胞的影響
Authors
Issue Date2001
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hk
Citation
Hong Kong Medical Journal, 2001, v. 7 n. 4, p. 408-413 How to Cite?
AbstractBupleurum-containing compounds, such as KY88 Liver Livo are thought to have immunomodulatory effects. This study investigated the effects of KY88 Liver Livo on the mitogenic induction of lymphocytes in vitro. Fifteen healthy human adult volunteers, aged between 20 and 50 years, provided peripheral blood samples from which lymphocytes were obtained by Ficoll-Hypaque centrifugation. The separated lymphocytes were stimulated by phytohaemagglutinin and KY88 Liver Livo in varying concentrations for 72 hours, with greater cluster and colony formation evident compared with lymphocytes in a control preparation. KY88 Liver Livo was also found to induce the secretion of granulocyte-macrophage colony-stimulating factor in a dose-dependent fashion. These preliminary in vitro studies suggest that KY88 Liver Livo may have potential clinical value in the treatment of chronic viral infection and in the management of immunocompromised patients.
Persistent Identifierhttp://hdl.handle.net/10722/45410
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChow, LWCen_HK
dc.contributor.authorLoo, TYen_HK
dc.contributor.authorSham, JSTen_HK
dc.date.accessioned2007-10-30T06:24:53Z-
dc.date.available2007-10-30T06:24:53Z-
dc.date.issued2001en_HK
dc.identifier.citationHong Kong Medical Journal, 2001, v. 7 n. 4, p. 408-413en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45410-
dc.description.abstractBupleurum-containing compounds, such as KY88 Liver Livo are thought to have immunomodulatory effects. This study investigated the effects of KY88 Liver Livo on the mitogenic induction of lymphocytes in vitro. Fifteen healthy human adult volunteers, aged between 20 and 50 years, provided peripheral blood samples from which lymphocytes were obtained by Ficoll-Hypaque centrifugation. The separated lymphocytes were stimulated by phytohaemagglutinin and KY88 Liver Livo in varying concentrations for 72 hours, with greater cluster and colony formation evident compared with lymphocytes in a control preparation. KY88 Liver Livo was also found to induce the secretion of granulocyte-macrophage colony-stimulating factor in a dose-dependent fashion. These preliminary in vitro studies suggest that KY88 Liver Livo may have potential clinical value in the treatment of chronic viral infection and in the management of immunocompromised patients.en_HK
dc.format.extent241672 bytes-
dc.format.extent2072 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org.hken_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBupleurumen_HK
dc.subject.meshCell Division - drug effectsen_HK
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor - pharmacologyen_HK
dc.subject.meshLymphocytes - drug effects - physiologyen_HK
dc.subject.meshPlant Preparations - administration & dosageen_HK
dc.titleEffects of a herbal compound containing bupleurum on human lymphocytesen_HK
dc.title含柴胡的草藥對人類淋巴細胞的影響zh_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=7&issue=4&spage=408&epage=413&date=2001&atitle=Effects+of+a+herbal+compound+containing+bupleurum+on+human+lymphocytesen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11773676-
dc.identifier.scopuseid_2-s2.0-0035677809-
dc.identifier.hkuros68711-

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