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Article: Somatostatin in the treatment of acute pancreatitis: A prospective randomised controlled trial

TitleSomatostatin in the treatment of acute pancreatitis: A prospective randomised controlled trial
Authors
Issue Date1989
PublisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 1989, v. 30 n. 2, p. 223-227 How to Cite?
AbstractA prospective study was carried out to evaluate the efficacy of somatostatin in the treatment of acute pancreatitis. Seventy one patients were randomised to control (h = 36), or to the somatostatin group (h = 35) who received somatostatin 100 μg/h after a 250 μg bolus for the first two days. The following were compared in the two groups on admission and two days later: laboratory tests of prognostic significance, severity of pancreatitis, and also morbidity and mortality. Of the nine laboratory tests compared, the white blood cell count, lactate dehydrogenase, and urea concentrations were significantly lower in the somatostatin group two days after admission. Severity of pancreatitis after hospitalisation increased in fewer patients given somatostatin (NS). There was a trend toward fewer complications, especially local, in the somatostatin group. Mortality in both groups was low. Somatostatin appeared to reduce the local complications of acute pancreatitis. A larger trial is necessary to show its beneficial effect conclusively.
Persistent Identifierhttp://hdl.handle.net/10722/45380
ISSN
2015 Impact Factor: 14.921
2015 SCImago Journal Rankings: 6.474
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChoi, TKen_HK
dc.contributor.authorMok, Fen_HK
dc.contributor.authorZhan, WHen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLai, ECSen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2007-10-30T06:24:13Z-
dc.date.available2007-10-30T06:24:13Z-
dc.date.issued1989en_HK
dc.identifier.citationGut, 1989, v. 30 n. 2, p. 223-227en_HK
dc.identifier.issn0017-5749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45380-
dc.description.abstractA prospective study was carried out to evaluate the efficacy of somatostatin in the treatment of acute pancreatitis. Seventy one patients were randomised to control (h = 36), or to the somatostatin group (h = 35) who received somatostatin 100 μg/h after a 250 μg bolus for the first two days. The following were compared in the two groups on admission and two days later: laboratory tests of prognostic significance, severity of pancreatitis, and also morbidity and mortality. Of the nine laboratory tests compared, the white blood cell count, lactate dehydrogenase, and urea concentrations were significantly lower in the somatostatin group two days after admission. Severity of pancreatitis after hospitalisation increased in fewer patients given somatostatin (NS). There was a trend toward fewer complications, especially local, in the somatostatin group. Mortality in both groups was low. Somatostatin appeared to reduce the local complications of acute pancreatitis. A larger trial is necessary to show its beneficial effect conclusively.en_HK
dc.format.extent759498 bytes-
dc.format.extent4540 bytes-
dc.format.extent4923 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_HK
dc.relation.ispartofGuten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsGut. Copyright © B M J Publishing Group.en_HK
dc.subject.meshPancreatitis-drug-therapyen_HK
dc.subject.meshSomatostatin-therapeutic-useen_HK
dc.titleSomatostatin in the treatment of acute pancreatitis: A prospective randomised controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-5749&volume=30&issue=2&spage=223&epage=227&date=1989&atitle=Somatostatin+in+the+treatment+of+acute+pancreatitis:+a+prospective+randomised+controlled+trialen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid2564834-
dc.identifier.pmcidPMC1378305-
dc.identifier.scopuseid_2-s2.0-0024583591en_HK
dc.identifier.volume30en_HK
dc.identifier.issue2en_HK
dc.identifier.spage223en_HK
dc.identifier.epage227en_HK
dc.identifier.isiWOS:A1989T330900015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChoi, TK=7202770029en_HK
dc.identifier.scopusauthoridMok, F=6603786245en_HK
dc.identifier.scopusauthoridZhan, WH=7102238647en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridLai, ECS=36932159600en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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