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Article: An in vivo intracellular study of auditory thalamic neurons

TitleAn in vivo intracellular study of auditory thalamic neurons
Authors
KeywordsAction potential
Current injection
Medial geniculate body
Resting membrane potential
Spontaneous firing
Tuning curve
Issue Date2003
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=THL
Citation
Thalamus And Related Systems, 2003, v. 2 n. 3, p. 253-260 How to Cite?
AbstractThe intrinsic electrophysiological properties of medial geniculate body (MGB) neurons and their responses to noise bursts/pure tones were examined in the pentobarbital anesthetized guinea pig through intracellular recording. Discharge rate was calculated in the absence of acoustic stimuli over varied membrane potentials which were changed by intracellular injection of current or through automatic drifting. The non-acoustically-driven firing rate was 45.8±23.3 Hz (mean±S.D., n=8) at membrane potentials of -45 mV, 30.6±19.4 Hz (n=14) at -50 mV, 18.0±12.9 Hz (n=14) at -55 mV, and significantly decreased to 5.7±7.4 Hz at -60 mV, and to 0.7±1.5 Hz (n=10) at -65 mV (ANOVA, P<0.001). The maximum non-acoustically-driven rate observed in the present study was 160 Hz. The auditory responsiveness of the MGB neurons was examined at membrane potentials over a range of -45 to -75 mV: the higher the membrane potential, the greater the responsiveness and vice versa. A putative non-low-threshold calcium spike (non-LTS) burst was observed in the present study. It showed significantly longer inter-spike intervals (11.6±6.0 ms, P<0.001, t -test) than those associated with the putative LTS bursts (6.7±2.4 ms, P<0.001, t-test). The dependence of the temporal structure of the spikes/spike bursts on the stimulus may provide insight into the temporal coding of sound information in the auditory system. © 2003 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/45291
ISSN
2011 SCImago Journal Rankings: 1.254
References

 

DC FieldValueLanguage
dc.contributor.authorXiong, Yen_HK
dc.contributor.authorYu, YQen_HK
dc.contributor.authorFujimoto, Ken_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2007-10-30T06:21:57Z-
dc.date.available2007-10-30T06:21:57Z-
dc.date.issued2003en_HK
dc.identifier.citationThalamus And Related Systems, 2003, v. 2 n. 3, p. 253-260en_HK
dc.identifier.issn1472-9288en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45291-
dc.description.abstractThe intrinsic electrophysiological properties of medial geniculate body (MGB) neurons and their responses to noise bursts/pure tones were examined in the pentobarbital anesthetized guinea pig through intracellular recording. Discharge rate was calculated in the absence of acoustic stimuli over varied membrane potentials which were changed by intracellular injection of current or through automatic drifting. The non-acoustically-driven firing rate was 45.8±23.3 Hz (mean±S.D., n=8) at membrane potentials of -45 mV, 30.6±19.4 Hz (n=14) at -50 mV, 18.0±12.9 Hz (n=14) at -55 mV, and significantly decreased to 5.7±7.4 Hz at -60 mV, and to 0.7±1.5 Hz (n=10) at -65 mV (ANOVA, P<0.001). The maximum non-acoustically-driven rate observed in the present study was 160 Hz. The auditory responsiveness of the MGB neurons was examined at membrane potentials over a range of -45 to -75 mV: the higher the membrane potential, the greater the responsiveness and vice versa. A putative non-low-threshold calcium spike (non-LTS) burst was observed in the present study. It showed significantly longer inter-spike intervals (11.6±6.0 ms, P<0.001, t -test) than those associated with the putative LTS bursts (6.7±2.4 ms, P<0.001, t-test). The dependence of the temporal structure of the spikes/spike bursts on the stimulus may provide insight into the temporal coding of sound information in the auditory system. © 2003 Elsevier Ltd. All rights reserved.en_HK
dc.format.extent857275 bytes-
dc.format.extent1980 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=THLen_HK
dc.relation.ispartofThalamus and Related Systemsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThalamus and Related Systems. Copyright © Cambridge University Press.en_HK
dc.subjectAction potentialen_HK
dc.subjectCurrent injectionen_HK
dc.subjectMedial geniculate bodyen_HK
dc.subjectResting membrane potentialen_HK
dc.subjectSpontaneous firingen_HK
dc.subjectTuning curveen_HK
dc.titleAn in vivo intracellular study of auditory thalamic neuronsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1472-9288&volume=2&issue=3&spage=253&epage=260&date=2003&atitle=An+in+vivo+intracellular+study+of+auditory+thalamic+neuronsen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1016/S1472-9288(03)00023-2en_HK
dc.identifier.scopuseid_2-s2.0-0042530512en_HK
dc.identifier.hkuros82054-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042530512&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue3en_HK
dc.identifier.spage253en_HK
dc.identifier.epage260en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXiong, Y=8706548900en_HK
dc.identifier.scopusauthoridYu, YQ=7406253532en_HK
dc.identifier.scopusauthoridFujimoto, K=7403304197en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridHe, J=7404984971en_HK

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