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Article: Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice

TitlePolysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
Authors
KeywordsAngelica sinensis
Polysaccharides
Cyclophosphamide
Leukopenia
Gastrointestinal tract
Issue Date2006
PublisherIvyspring International Publisher. The Journal's web site is located at http://www.medsci.org/
Citation
International Journal of Medical Sciences, 2006, v. 3 n. 1, p. 1-6 How to Cite?
AbstractCyclophosphamide (CY) is a cytostatic agent that produces systemic toxicity especially on cells with high proliferative capacity, while polysaccharides from Angelica sinensis (AP) have been shown to increase the turnover of gastrointestinal mucosal and hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on CY-induced leukopenia and proliferative arrest in the gastroduodenal mucosa in mice. Subcutaneous injection of CY (200 mg/kg) provoked dramatic decrease in white blood cell (WBC) count and number of blood vessels and proliferating cells in both the gastric and duodenal mucosae. Subcutaneous injection of AP significantly promoted the recovery from leukopenia and increased number of blood vessels and proliferating cells in both the gastric and duodenal tissues. Western blotting revealed that CY significantly down-regulated the protein expression of vascular endothelial growth factor (VEGF), c-Myc and ornithine decarboxylase (ODC) in gastric mucosae but had no effect on epidermal growth factor (EGF) expression. AP also reversed the dampening effect of CY on VEGF expression in the gastric mucosa. These data suggest that AP is a cytoprotective agent which can protect against the cytotoxicity of CY on hematopoietic and gastrointestinal tissues when the polysaccharide is co-administered with CY in cancer patients during treatment regimen.
Persistent Identifierhttp://hdl.handle.net/10722/45239
ISSN
2015 Impact Factor: 2.232
2015 SCImago Journal Rankings: 0.813
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorHui, MKCen_HK
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorShin, VYen_HK
dc.contributor.authorSo, WHLen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2007-10-30T06:20:38Z-
dc.date.available2007-10-30T06:20:38Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal of Medical Sciences, 2006, v. 3 n. 1, p. 1-6en_HK
dc.identifier.issn1449-1907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45239-
dc.description.abstractCyclophosphamide (CY) is a cytostatic agent that produces systemic toxicity especially on cells with high proliferative capacity, while polysaccharides from Angelica sinensis (AP) have been shown to increase the turnover of gastrointestinal mucosal and hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on CY-induced leukopenia and proliferative arrest in the gastroduodenal mucosa in mice. Subcutaneous injection of CY (200 mg/kg) provoked dramatic decrease in white blood cell (WBC) count and number of blood vessels and proliferating cells in both the gastric and duodenal mucosae. Subcutaneous injection of AP significantly promoted the recovery from leukopenia and increased number of blood vessels and proliferating cells in both the gastric and duodenal tissues. Western blotting revealed that CY significantly down-regulated the protein expression of vascular endothelial growth factor (VEGF), c-Myc and ornithine decarboxylase (ODC) in gastric mucosae but had no effect on epidermal growth factor (EGF) expression. AP also reversed the dampening effect of CY on VEGF expression in the gastric mucosa. These data suggest that AP is a cytoprotective agent which can protect against the cytotoxicity of CY on hematopoietic and gastrointestinal tissues when the polysaccharide is co-administered with CY in cancer patients during treatment regimen.en_HK
dc.format.extent422269 bytes-
dc.format.extent2097 bytes-
dc.format.extent3803 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIvyspring International Publisher. The Journal's web site is located at http://www.medsci.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAngelica sinensisen_HK
dc.subjectPolysaccharidesen_HK
dc.subjectCyclophosphamideen_HK
dc.subjectLeukopeniaen_HK
dc.subjectGastrointestinal tracten_HK
dc.titlePolysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1449-1907&volume=3&issue=1&spage=1&epage=6&date=2006&atitle=Polysaccharides+from+the+root+of+Angelica+sinensis+protect+bone+marrow+and+gastrointestinal+tissues+against+the+cytotoxicity+of+cyclophosphamide+in+miceen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid16421623en_HK
dc.identifier.pmcidPMC1332197-
dc.identifier.scopuseid_2-s2.0-29944443508-
dc.identifier.hkuros119605-

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