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Article: Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice

TitleAnti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice
Authors
KeywordsPCNA
Apoptosis
Angiogenesis
Gastric cancer
Issue Date2004
PublisherIvyspring International Publisher. The Journal's web site is located at http://www.medsci.org/
Citation
International Journal of Medical Sciences, 2004, v. 1 n. 3, p. 137-145 How to Cite?
AbstractNatural botanical products can be integrated with western medicine to optimize the treatment outcome, increase immune function and minimize the side effects from western drug treatment. CKBM is a combination of herbs and yeasts formulated based on traditional Chinese medicinal principles. Previous study has demonstrated that CKBM is capable of improving immune responsiveness through the induction of cytokine mediators, such as TNF-α and IL-6. In this study, we aimed to investigate the effect of this immunomodulatory drug on gastric cancer growth using a human xenograft model. Gastric cancer tissues were implanted subcutaneously into athymic nude mice followed by a 14-day or 28-day of CKBM treatment. Results showed that higher doses of CKBM (0.4 or 0.8 ml/mouse/day) produced a dose-dependent inhibitory effect on gastric tumor growth after 28-day drug treatment. This was associated with a decrease of cellular proliferation by 30% with concomitant increase in apoptosis by 97% in gastric tumor cells when compared with the control group. In contrast, CKBM showed no effect on angiogenesis in gastric tumors. This study demonstrates the anti-tumorigenic action of CKBM on gastric cancer probably via inhibition of cell proliferation and induction of apoptosis, and provides future potential targets of this drug candidate on cancer therapy.
Persistent Identifierhttp://hdl.handle.net/10722/45237
ISSN
2015 Impact Factor: 2.232
2015 SCImago Journal Rankings: 0.813
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorShin, VYen_HK
dc.contributor.authorSo, WHLen_HK
dc.contributor.authorLiu, ESLen_HK
dc.contributor.authorWu, YJen_HK
dc.contributor.authorPang, SFen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2007-10-30T06:20:34Z-
dc.date.available2007-10-30T06:20:34Z-
dc.date.issued2004en_HK
dc.identifier.citationInternational Journal of Medical Sciences, 2004, v. 1 n. 3, p. 137-145en_HK
dc.identifier.issn1449-1907en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45237-
dc.description.abstractNatural botanical products can be integrated with western medicine to optimize the treatment outcome, increase immune function and minimize the side effects from western drug treatment. CKBM is a combination of herbs and yeasts formulated based on traditional Chinese medicinal principles. Previous study has demonstrated that CKBM is capable of improving immune responsiveness through the induction of cytokine mediators, such as TNF-α and IL-6. In this study, we aimed to investigate the effect of this immunomodulatory drug on gastric cancer growth using a human xenograft model. Gastric cancer tissues were implanted subcutaneously into athymic nude mice followed by a 14-day or 28-day of CKBM treatment. Results showed that higher doses of CKBM (0.4 or 0.8 ml/mouse/day) produced a dose-dependent inhibitory effect on gastric tumor growth after 28-day drug treatment. This was associated with a decrease of cellular proliferation by 30% with concomitant increase in apoptosis by 97% in gastric tumor cells when compared with the control group. In contrast, CKBM showed no effect on angiogenesis in gastric tumors. This study demonstrates the anti-tumorigenic action of CKBM on gastric cancer probably via inhibition of cell proliferation and induction of apoptosis, and provides future potential targets of this drug candidate on cancer therapy.en_HK
dc.format.extent101815 bytes-
dc.format.extent2097 bytes-
dc.format.extent3803 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherIvyspring International Publisher. The Journal's web site is located at http://www.medsci.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectPCNAen_HK
dc.subjectApoptosisen_HK
dc.subjectAngiogenesisen_HK
dc.subjectGastric canceren_HK
dc.titleAnti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1449-1907&volume=1&issue=3&spage=137&epage=145&date=2004&atitle=Anti-tumorigenic+and+Pro-apoptotic+effects+of+CKBM+on+gastric+cancer+growth+in+nude+miceen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid15912192en_HK
dc.identifier.pmcidPMC1074708-
dc.identifier.hkuros104920-

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