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Article: Paediatric hepatoblastoma and hepatocellular carcinoma: retrospective study.

TitlePaediatric hepatoblastoma and hepatocellular carcinoma: retrospective study.
Authors
Issue Date2002
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2002, v. 8 n. 1, p. 13-17 How to Cite?
AbstractOBJECTIVES: To compare and contrast clinical characteristics and outcomes of hepatoblastoma or hepatocellular carcinoma in paediatric patients. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS AND METHODS: Medical records of 22 paediatric patients with hepatoblastoma (n=11) or hepatocellular carcinoma (n=11) admitted to Queen Mary Hospital between 1989 and 2000 were reviewed. Data gathered included demographic data, results of liver function tests, hepatitis A, B, and C titres, and alpha-foetoprotein levels, and imaging studies including chest X-ray, ultrasound study, computed tomography scan, and magnetic resonance imaging/hepatic angiogram for tumour staging and resectability. RESULTS: The mean age of patients with hepatoblastoma was 18 months (range, 5 months to 3 years), while that of patients with hepatocellular carcinoma was 10.2 years (range, 2 to 16 years). Females predominated in the hepatoblastoma group (female:male, 8:3) and males in the hepatocellular carcinoma group (male:female, 10:1). None of the patients with hepatoblastoma were hepatitis B surface antigen positive, in contrast to 64% of the hepatocellular carcinoma group. Only 45% of the hepatocellular carcinomas were resectable at presentation and this figure remained unchanged following chemotherapy. A total of 91% of hepatoblastomas were resectable, four at presentation, and a further six after chemotherapy. Tumour rupture was more common in patients with hepatoblastoma than in those with hepatocellular carcinoma (36% versus 9% of cases, respectively). Mortality rates were considerably higher among the hepatocellular carcinoma group than the hepatoblastoma group in this series. CONCLUSION: Childhood hepatoblastoma and hepatocellular carcinoma differ with respect to age and tumour stage at presentation, hepatatis B surface antigen status, tendency to rupture, chemosensitivity, and prognosis.
Persistent Identifierhttp://hdl.handle.net/10722/45232
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChan, KLen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorTam, PKen_HK
dc.contributor.authorChiang, AKen_HK
dc.contributor.authorChan, GCen_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2007-10-30T06:20:26Z-
dc.date.available2007-10-30T06:20:26Z-
dc.date.issued2002en_HK
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2002, v. 8 n. 1, p. 13-17en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45232-
dc.description.abstractOBJECTIVES: To compare and contrast clinical characteristics and outcomes of hepatoblastoma or hepatocellular carcinoma in paediatric patients. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS AND METHODS: Medical records of 22 paediatric patients with hepatoblastoma (n=11) or hepatocellular carcinoma (n=11) admitted to Queen Mary Hospital between 1989 and 2000 were reviewed. Data gathered included demographic data, results of liver function tests, hepatitis A, B, and C titres, and alpha-foetoprotein levels, and imaging studies including chest X-ray, ultrasound study, computed tomography scan, and magnetic resonance imaging/hepatic angiogram for tumour staging and resectability. RESULTS: The mean age of patients with hepatoblastoma was 18 months (range, 5 months to 3 years), while that of patients with hepatocellular carcinoma was 10.2 years (range, 2 to 16 years). Females predominated in the hepatoblastoma group (female:male, 8:3) and males in the hepatocellular carcinoma group (male:female, 10:1). None of the patients with hepatoblastoma were hepatitis B surface antigen positive, in contrast to 64% of the hepatocellular carcinoma group. Only 45% of the hepatocellular carcinomas were resectable at presentation and this figure remained unchanged following chemotherapy. A total of 91% of hepatoblastomas were resectable, four at presentation, and a further six after chemotherapy. Tumour rupture was more common in patients with hepatoblastoma than in those with hepatocellular carcinoma (36% versus 9% of cases, respectively). Mortality rates were considerably higher among the hepatocellular carcinoma group than the hepatoblastoma group in this series. CONCLUSION: Childhood hepatoblastoma and hepatocellular carcinoma differ with respect to age and tumour stage at presentation, hepatatis B surface antigen status, tendency to rupture, chemosensitivity, and prognosis.en_HK
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dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, Hepatocellular - epidemiology - pathologyen_HK
dc.subject.meshHepatoblastoma - epidemiology - pathologyen_HK
dc.subject.meshLiver Neoplasms - epidemiology - pathologyen_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.titlePaediatric hepatoblastoma and hepatocellular carcinoma: retrospective study.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=8&issue=1&spage=13&epage=17&date=2002&atitle=Paediatric+hepatoblastoma+and+hepatocellular+carcinoma:+retrospective+studyen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailTam, PK: paultam@hkucc.hku.hken_HK
dc.identifier.emailChiang, AK: chiangak@hkucc.hku.hken_HK
dc.identifier.emailChan, GC: gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityTam, PK=rp00060en_HK
dc.identifier.authorityChiang, AK=rp00403en_HK
dc.identifier.authorityChan, GC=rp00431en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11861987-
dc.identifier.scopuseid_2-s2.0-0036481805en_HK
dc.identifier.hkuros65441-
dc.identifier.volume8en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage17en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridChan, KL=37004089600en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridTam, PK=7202539421en_HK
dc.identifier.scopusauthoridChiang, AK=7101623534en_HK
dc.identifier.scopusauthoridChan, GC=16160154400en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK

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