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Article: Effect of indomethacin on binding of bilirubin to albumin

TitleEffect of indomethacin on binding of bilirubin to albumin
Authors
Lam, BCCWong, HNYeung, CY
Issue Date1990
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives of Disease in Childhood, 1990, v. 65 n. 7 Spec No, p. 690-691 How to Cite?
DOI: http://dx.doi.org/10.1136/adc.65.7_Spec_No.690
AbstractThe effect of indomethacin on the binding of bilirubin to protein was studied in vitro by the horseradish peroxidase oxidation method. Plasma indomethacin concentrations ranging from 1500 micrograms/l to 4500 micrograms/l, which were much higher than the therapeutic concentrations achieved in vivo, were used for the studies. The bilirubin-protein titration curves obtained indicate that indomethacin, although protein bound, does not affect the binding of bilirubin to protein. Our study confirms that it is safe to use conventional doses of indomethacin in jaundiced preterm infants.
Persistent Identifierhttp://hdl.handle.net/10722/45212
ISSN
0003-9888
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 0.935
PubMed Central ID
PMC1590185
ISI Accession Number ID
WOS:A1990DM61100012

 

DC FieldValueLanguage
dc.contributor.authorLam, BCCen_HK
dc.contributor.authorWong, HNen_HK
dc.contributor.authorYeung, CYen_HK
dc.date.accessioned2007-10-30T06:20:00Z-
dc.date.available2007-10-30T06:20:00Z-
dc.date.issued1990en_HK
dc.identifier.citationArchives of Disease in Childhood, 1990, v. 65 n. 7 Spec No, p. 690-691en_HK
dc.identifier.issn0003-9888en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45212-
dc.description.abstractThe effect of indomethacin on the binding of bilirubin to protein was studied in vitro by the horseradish peroxidase oxidation method. Plasma indomethacin concentrations ranging from 1500 micrograms/l to 4500 micrograms/l, which were much higher than the therapeutic concentrations achieved in vivo, were used for the studies. The bilirubin-protein titration curves obtained indicate that indomethacin, although protein bound, does not affect the binding of bilirubin to protein. Our study confirms that it is safe to use conventional doses of indomethacin in jaundiced preterm infants.en_HK
dc.format.extent354124 bytes-
dc.format.extent2346 bytes-
dc.format.extent3430 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_HK
dc.rightsArchives of Disease in Childhood. Copyright © B M J Publishing Group.en_HK
dc.subject.meshBilirubin-blooden_HK
dc.subject.meshIndomethacin-pharmacologyen_HK
dc.subject.meshSerum-Albumin-metabolismen_HK
dc.titleEffect of indomethacin on binding of bilirubin to albuminen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9888&volume=65&issue=7 Spec No&spage=690&epage=691&date=1990&atitle=Effect+of+indomethacin+on+binding+of+bilirubin+to+albuminen_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/adc.65.7_Spec_No.690-
dc.identifier.pmid2386402-
dc.identifier.pmcidPMC1590185-
dc.identifier.scopuseid_2-s2.0-0025313641-
dc.identifier.isiWOS:A1990DM61100012-
dc.identifier.issnl0003-9888-

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