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Article: Prevention of spinal cord injury with time-frequency analysis of evoked potentials: An experimental study

TitlePrevention of spinal cord injury with time-frequency analysis of evoked potentials: An experimental study
Authors
KeywordsEvoked potential
Spinal cord injury
Time frequency analysis
Issue Date2001
PublisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/
Citation
Journal Of Neurology Neurosurgery And Psychiatry, 2001, v. 71 n. 6, p. 732-740 How to Cite?
AbstractObjectives - To verify the applicability and validity of time-frequency analysis (TFA) of evoked potential (EP) signals in detecting the integrity of spinal cord function and preventing spinal cord injury. Methods - The spinal cord was simulated during surgery in 20 mature rats by mechanically damaging the spinal cord. Cortical somatosensory evoked potential (CSEP), spinal somatosensory evoked potential (SSEP), cortical motor evoked potential (CMEP), and spinal cord evoked potential (SCEP) were used to monitor spinal cord function. Short time Fourier transform (STFT) was applied to the CSEP signal, and cone shaped distribution (CSD) was used as the TFA algorithm for SSEP, CMEP, and SCEP signals. The changes in the latency and amplitude of EP signals were measured in the time domain, and peak time, peak frequency, and peak power were measured in the time-frequency distribution (TFD). Results - The TFDs of EPs were found to concentrate in a certain location under normal conditions. When injury occurred, the energy decreased in peak power, and there was a greater dispersion of energy across the time-frequency range. Strong relations were found between latency and peak time, and amplitude and peak power. However, the change in peak power after injury was significantly larger than the corresponding change in amplitude (p<0.001 by ANOVA). Conclusions - It was found that TFA of EPs provided an earlier and more sensitive indication of injury than time domain monitoring alone. It is suggested that TFA of EP signals should therefore be useful in preventing spinal cord injury during surgery.
Persistent Identifierhttp://hdl.handle.net/10722/45206
ISSN
2015 Impact Factor: 6.431
2015 SCImago Journal Rankings: 2.913
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHu, Yen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorHolmes, Aen_HK
dc.contributor.authorLeong, JCYen_HK
dc.date.accessioned2007-10-30T06:19:49Z-
dc.date.available2007-10-30T06:19:49Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Neurology Neurosurgery And Psychiatry, 2001, v. 71 n. 6, p. 732-740en_HK
dc.identifier.issn0022-3050en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45206-
dc.description.abstractObjectives - To verify the applicability and validity of time-frequency analysis (TFA) of evoked potential (EP) signals in detecting the integrity of spinal cord function and preventing spinal cord injury. Methods - The spinal cord was simulated during surgery in 20 mature rats by mechanically damaging the spinal cord. Cortical somatosensory evoked potential (CSEP), spinal somatosensory evoked potential (SSEP), cortical motor evoked potential (CMEP), and spinal cord evoked potential (SCEP) were used to monitor spinal cord function. Short time Fourier transform (STFT) was applied to the CSEP signal, and cone shaped distribution (CSD) was used as the TFA algorithm for SSEP, CMEP, and SCEP signals. The changes in the latency and amplitude of EP signals were measured in the time domain, and peak time, peak frequency, and peak power were measured in the time-frequency distribution (TFD). Results - The TFDs of EPs were found to concentrate in a certain location under normal conditions. When injury occurred, the energy decreased in peak power, and there was a greater dispersion of energy across the time-frequency range. Strong relations were found between latency and peak time, and amplitude and peak power. However, the change in peak power after injury was significantly larger than the corresponding change in amplitude (p<0.001 by ANOVA). Conclusions - It was found that TFA of EPs provided an earlier and more sensitive indication of injury than time domain monitoring alone. It is suggested that TFA of EP signals should therefore be useful in preventing spinal cord injury during surgery.en_HK
dc.format.extent453487 bytes-
dc.format.extent597583 bytes-
dc.format.extent4339 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/en_HK
dc.relation.ispartofJournal of Neurology Neurosurgery and Psychiatryen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Neurology, Neurosurgery and Psychiatry. Copyright © B M J Publishing Group.en_HK
dc.subjectEvoked potentialen_HK
dc.subjectSpinal cord injuryen_HK
dc.subjectTime frequency analysisen_HK
dc.titlePrevention of spinal cord injury with time-frequency analysis of evoked potentials: An experimental studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3050&volume=71&issue=6&spage=732&epage=740&date=2001&atitle=Prevention+of+spinal+cord+injury+with+time-frequency+analysis+of+evoked+potentials:+an+experimental+studyen_HK
dc.identifier.emailHu, Y:yhud@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityHu, Y=rp00432en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/jnnp.71.6.732en_HK
dc.identifier.pmid11723192-
dc.identifier.pmcidPMC1737639-
dc.identifier.scopuseid_2-s2.0-0035209189en_HK
dc.identifier.hkuros71313-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035209189&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue6en_HK
dc.identifier.spage732en_HK
dc.identifier.epage740en_HK
dc.identifier.isiWOS:000172442300008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHu, Y=7407116091en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridHolmes, A=7401687268en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK

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